{"id":10679,"date":"2026-03-11T07:42:43","date_gmt":"2026-03-11T07:42:43","guid":{"rendered":"https:\/\/longchangextracts.com\/benzyl-nicotinate-cas-94-44-0\/"},"modified":"2026-03-11T07:49:36","modified_gmt":"2026-03-11T07:49:36","slug":"benzyl-nicotinate-cas-94-44-0","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/es\/benzyl-nicotinate-cas-94-44-0\/","title":{"rendered":"Benzyl Nicotinate (CAS 94-44-0): A Comprehensive Guide to This Topical Vasodilator"},"content":{"rendered":"<h1>Benzyl Nicotinate (CAS 94-44-0): A Comprehensive Guide to This Topical Vasodilator<\/h1>\n<h2>What is Benzyl Nicotinate?<\/h2>\n<p>Benzyl nicotinate is a benzyl ester derived from the formal condensation of the carboxy group of nicotinic acid (vitamin B3) with benzyl alcohol. With the chemical formula C13H11NO2 and a molecular weight of 213.24 g\/mol, this compound belongs to the nicotinate family and is recognized for its distinctive rubefacient properties.<\/p>\n<p><strong>CAS Number:<\/strong> 94-44-0<br \/>\n<strong>EC Number:<\/strong> 202-332-3<br \/>\n<strong>Sin\u00f3nimos:<\/strong> Nicotinic acid benzyl ester<\/p>\n<p>Benzyl nicotinate functions as a lipophilic pro-drug that rapidly penetrates the skin. Upon enzymatic hydrolysis, it releases nicotinic acid, which leads to increased cutaneous blood flow through vasodilator prostaglandins. This mechanism makes it a valuable ingredient in various topical pharmaceutical and cosmetic formulations.<\/p>\n<h2>What Are the Benefits?<\/h2>\n<h3>Enhanced Skin Blood Flow<\/h3>\n<p>The primary benefit of benzyl nicotinate is its ability to increase skin oxygenation levels by significantly enhancing skin blood flow. This vasodilatory effect promotes better circulation in the applied area, which can be particularly beneficial in therapeutic applications.<\/p>\n<h3>Improved Drug Delivery<\/h3>\n<p>As a lipophilic pro-drug, benzyl nicotinate serves as an effective penetration enhancer. It helps other active ingredients cross the skin barrier more efficiently, making it a valuable addition to transdermal drug delivery systems.<\/p>\n<h3>Rubefacient Properties<\/h3>\n<p>Benzyl nicotinate induces rubefaction\u2014a reddening of the skin caused by increased blood flow. This property makes it useful in topical preparations designed to relieve muscle and joint discomfort by promoting local circulation.<\/p>\n<h3>Topical Analgesic Enhancement<\/h3>\n<p>When combined with analgesics in topical preparations, benzyl nicotinate can enhance the overall pain-relieving effect. Research has shown it works effectively in combination with anti-inflammatory agents and other pain-relieving compounds.<\/p>\n<h3>Cosmetic Applications<\/h3>\n<p>In cosmetics, benzyl nicotinate is used for its ability to improve skin appearance by promoting blood circulation, which can give the skin a healthier, more vibrant look.<\/p>\n<h2>What Are the Uses?<\/h2>\n<h3>Pharmaceutical Formulations<\/h3>\n<p>Benzyl nicotinate is primarily used in:<\/p>\n<ul>\n<li>Topical analgesic preparations<\/li>\n<li>Anti-inflammatory gels and creams<\/li>\n<li>Rubefacient ointments for muscle relief<\/li>\n<li>Transdermal patch formulations<\/li>\n<li>Combination products with NSAIDs (non-steroidal anti-inflammatory drugs)<\/li>\n<\/ul>\n<h3>Cosmetic Products<\/h3>\n<p>In the cosmetics industry, benzyl nicotinate is found in:<\/p>\n<ul>\n<li>Anti-aging creams and serums<\/li>\n<li>Skin revitalizing formulations<\/li>\n<li>Body lotions for improving circulation<\/li>\n<li>Products designed to enhance skin radiance<\/li>\n<\/ul>\n<h3>Research Applications<\/h3>\n<p>Benzyl nicotinate serves as a valuable research tool in studies involving:<\/p>\n<ul>\n<li>Skin permeability and penetration enhancement<\/li>\n<li>Cutaneous blood flow measurement<\/li>\n<li>Vasodilator mechanism investigations<\/li>\n<\/ul>\n<h2>Safety and Side Effects<\/h2>\n<h3>Common Side Effects<\/h3>\n<p>The most frequently reported side effects of benzyl nicotinate include:<\/p>\n<ul>\n<li><strong>Skin irritation<\/strong> at the application site<\/li>\n<li><strong>Redness (erythema)<\/strong> due to increased blood flow<\/li>\n<li><strong>Burning sensation<\/strong> or warmth<\/li>\n<li><strong>Itching<\/strong> or mild discomfort<\/li>\n<li><strong>Stinging sensation<\/strong> during application<\/li>\n<\/ul>\n<p>These effects are typically transient and related to the compound&#8217;s vasodilatory mechanism.<\/p>\n<h3>Precauciones<\/h3>\n<ul>\n<li>Benzyl nicotinate should only be applied topically<\/li>\n<li>Avoid contact with eyes, mucous membranes, and broken skin<\/li>\n<li>Do not use on sensitive areas without medical consultation<\/li>\n<li>Wash hands thoroughly after application<\/li>\n<li>Avoid applying to large areas of the body without professional guidance<\/li>\n<\/ul>\n<h3>Contraindications<\/h3>\n<ul>\n<li>Known hypersensitivity to nicotinic acid or benzyl alcohol<\/li>\n<li>Open wounds or damaged skin<\/li>\n<li>Severe skin conditions at the application site<\/li>\n<\/ul>\n<h2>Chemical Specifications<\/h2>\n<table>\n<tr>\n<th>Property<\/th>\n<th>Valor<\/th>\n<\/tr>\n<tr>\n<td>N\u00famero CAS<\/td>\n<td>94-44-0<\/td>\n<\/tr>\n<tr>\n<td>F\u00f3rmula molecular<\/td>\n<td>C13H11NO2<\/td>\n<\/tr>\n<tr>\n<td>Peso molecular<\/td>\n<td>213.24 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>Apariencia<\/td>\n<td>Polvo cristalino entre blanco y blanquecino<\/td>\n<\/tr>\n<tr>\n<td>Pureza<\/td>\n<td>\u226598% (GC)<\/td>\n<\/tr>\n<tr>\n<td>EC Number<\/td>\n<td>202-332-3<\/td>\n<\/tr>\n<\/table>\n<h2>Frequently Asked Questions<\/h2>\n<h3>Is Benzyl Nicotinate safe for daily use?<\/h3>\n<p>When used as directed in topical formulations, benzyl nicotinate is generally considered safe. However, some individuals may experience skin sensitivity. It&#8217;s recommended to perform a patch test before regular use.<\/p>\n<h3>How does Benzyl Nicotinate work?<\/h3>\n<p>Benzyl nicotinate acts as a pro-drug that penetrates the skin and releases nicotinic acid through enzymatic hydrolysis. This nicotinic acid then stimulates the production of vasodilator prostaglandins, increasing blood flow to the area.<\/p>\n<h3>Can Benzyl Nicotinate be used with other medications?<\/h3>\n<p>Benzyl nicotinate is often combined with analgesics and anti-inflammatory agents to enhance their effectiveness. However, it&#8217;s important to consult a healthcare professional before using combination products.<\/p>\n<h3>What is the difference between Benzyl Nicotinate and Nicotinic Acid?<\/h3>\n<p>While both compounds are related, benzyl nicotinate is an ester derivative designed for topical application. It offers better skin penetration and a more controlled release compared to direct application of nicotinic acid.<\/p>\n<h3>Does Benzyl Nicotinate cause flushing?<\/h3>\n<p>Yes, flushing or redness at the application site is a common effect due to increased blood flow. This is a normal response and typically subsides after a short period.<\/p>\n<h2>Why Choose Our Benzyl Nicotinate?<\/h2>\n<ul>\n<li><strong>High Purity<\/strong>: Our Benzyl Nicotinate meets or exceeds industry standards with \u226598% purity<\/li>\n<li><strong>Quality Assurance<\/strong>: Every batch is tested to ensure consistent quality and performance<\/li>\n<li><strong>Competitive Pricing<\/strong>: We offer premium-quality products at competitive wholesale rates<\/li>\n<li><strong>Reliable Supply<\/strong>: Consistent availability for bulk orders and regular supply<\/li>\n<li><strong>Technical Support<\/strong>: Our team provides technical assistance and product documentation<\/li>\n<li><strong>Global Shipping<\/strong>: Efficient worldwide distribution capabilities<\/li>\n<\/ul>\n<h2>Related Products<\/h2>\n<p>If you&#8217;re interested in Benzyl Nicotinate, you may also find these related compounds useful:<\/p>\n<ul>\n<li><a href=\"https:\/\/longchangextracts.com\/es\/product\/acido-nicotinico-cas-59-67-6\/\">Nicotinic Acid (Vitamin B3)<\/a><\/li>\n<li><a href=\"https:\/\/longchangextracts.com\/es\/?s=benzyl alcohol\">Benzyl Alcohol<\/a><\/li>\n<li><a href=\"https:\/\/longchangextracts.com\/es\/product\/acido-alfa-lipoico-cas-1077-28-7\/\">Alpha Lipoic Acid<\/a><\/li>\n<li><a href=\"https:\/\/longchangextracts.com\/es\/product\/nicotinato-de-metilo-cas-93-60-7\/\">Methyl Nicotinate<\/a><\/li>\n<\/ul>\n<p><em>Disclaimer:<\/em> This information is provided for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional before using any pharmaceutical compound.<\/p>","protected":false},"excerpt":{"rendered":"<p>Benzyl Nicotinate (CAS 94-44-0): A Comprehensive Guide to This Topical Vasodilator What is Benzyl Nicotinate? Benzyl nicotinate is a benzyl ester derived from the formal condensation of the carboxy group of nicotinic acid (vitamin B3) with benzyl alcohol. With the chemical formula C13H11NO2 and a molecular weight of 213.24 g\/mol, this compound belongs to the [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Benzyl Nicotinate (CAS 94-44-0): A Comprehensive Guide to This Topical Vasodilator - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/es\/benzyl-nicotinate-cas-94-44-0\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Benzyl Nicotinate (CAS 94-44-0): A Comprehensive Guide to This Topical Vasodilator - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Benzyl Nicotinate (CAS 94-44-0): A Comprehensive Guide to This Topical Vasodilator What is Benzyl Nicotinate? 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Benzyl nicotinate is a benzyl ester derived from the formal condensation of the carboxy group of nicotinic acid (vitamin B3) with benzyl alcohol. 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