{"id":10645,"date":"2026-03-10T03:20:59","date_gmt":"2026-03-10T03:20:59","guid":{"rendered":"https:\/\/longchangextracts.com\/calcifediol-monohydrate-cas-63283-36-3-a-comprehensive-guide-to-this-essential-vitamin-d-metabolite\/"},"modified":"2026-03-10T03:20:59","modified_gmt":"2026-03-10T03:20:59","slug":"calcifediol-monohydrate-cas-63283-36-3-a-comprehensive-guide-to-this-essential-vitamin-d-metabolite","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/es\/calcifediol-monohydrate-cas-63283-36-3-a-comprehensive-guide-to-this-essential-vitamin-d-metabolite\/","title":{"rendered":"Calcifediol Monohydrate (CAS 63283-36-3): A Comprehensive Guide to This Essential Vitamin D Metabolite"},"content":{"rendered":"<p><!--more--><\/p>\n<h2>What is Calcifediol Monohydrate?<\/h2>\n<p><strong>Calcifediol Monohydrate<\/strong>, also known as <strong>25-Hydroxyvitamin D3 Monohydrate<\/strong> o <strong>25-Hydroxycholecalciferol Monohydrate<\/strong>, is the major circulating metabolite of vitamin D3 in the human body. This compound serves as a crucial prehormone and is produced in the liver through the hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase.<\/p>\n<p>Calcifediol represents a vital intermediate in the vitamin D metabolic pathway. Unlike its precursor vitamin D3 or its active form calcitriol (1,25-dihydroxyvitamin D3), calcifediol has a longer half-life in the bloodstream and is considered the best indicator of a patient&#8217;s vitamin D status. This makes it clinically significant for diagnosing and monitoring vitamin D deficiency.<\/p>\n<h2>Chemical Properties of Calcifediol Monohydrate<\/h2>\n<table>\n<tr>\n<td><strong>N\u00famero CAS<\/strong><\/td>\n<td>63283-36-3<\/td>\n<\/tr>\n<tr>\n<td><strong>F\u00f3rmula molecular<\/strong><\/td>\n<td>C\u2082\u2087H\u2084\u2084O\u2082 \u00b7 H\u2082O<\/td>\n<\/tr>\n<tr>\n<td><strong>Peso molecular<\/strong><\/td>\n<td>418.65 g\/mol<\/td>\n<\/tr>\n<tr>\n<td><strong>Sin\u00f3nimos<\/strong><\/td>\n<td>25-Hydroxyvitamin D3, 25-Hydroxycholecalciferol, Calcidiol<\/td>\n<\/tr>\n<tr>\n<td><strong>Apariencia<\/strong><\/td>\n<td>White to light yellow powder or crystal<\/td>\n<\/tr>\n<tr>\n<td><strong>Pureza<\/strong><\/td>\n<td>\u226598% (HPLC)<\/td>\n<\/tr>\n<tr>\n<td><strong>Solubilidad<\/strong><\/td>\n<td>Soluble in organic solvents<\/td>\n<\/tr>\n<tr>\n<td><strong>Clasificaci\u00f3n<\/strong><\/td>\n<td>API (Active Pharmaceutical Ingredient)<\/td>\n<\/tr>\n<\/table>\n<h2>Benefits and Therapeutic Applications<\/h2>\n<h3>Vitamin D Status Indicator<\/h3>\n<p>Calcifediol is considered the <strong>best biomarker for assessing vitamin D status<\/strong> in patients. Unlike other vitamin D metabolites, it has a circulating half-life of approximately 2-3 weeks, making it more stable for laboratory measurements. Healthcare providers worldwide measure calcifediol concentrations to determine whether a patient has sufficient vitamin D levels.<\/p>\n<h3>Treatment of Vitamin D Deficiency<\/h3>\n<p>Calcifediol monohydrate is used as a <strong>supplement for treating vitamin D deficiency<\/strong>. It offers advantages over other forms of vitamin D because:<\/p>\n<ul>\n<li><strong>Better intestinal absorption<\/strong> &#8211; more readily absorbed compared to other vitamin D forms<\/li>\n<li><strong>Direct utilization<\/strong> &#8211; already in the form that the body stores<\/li>\n<li><strong>Effective for patients with liver dysfunction<\/strong> &#8211; bypasses the need for hepatic conversion<\/li>\n<\/ul>\n<h3>Chronic Kidney Disease (CKD) Management<\/h3>\n<p>One of the most important therapeutic applications of calcifediol is in treating <strong>secondary hyperparathyroidism associated with chronic kidney disease<\/strong>. Patients with CKD often have impaired kidney function that affects vitamin D activation. Extended-release calcifediol formulations have been shown to:<\/p>\n<ul>\n<li>Effectively raise serum 25-hydroxyvitamin D levels<\/li>\n<li>Suppress parathyroid hormone (iPTH) levels<\/li>\n<li>Improve calcium and phosphorus metabolism<\/li>\n<li>Manage vitamin D insufficiency in stage 3-4 CKD patients<\/li>\n<\/ul>\n<h3>Skin Health Benefits<\/h3>\n<p>Research has shown that calcifediol monohydrate may provide benefits for skin health:<\/p>\n<ul>\n<li>Reduces inflammatory cell infiltration<\/li>\n<li>Inhibits STAT3 phosphorylation<\/li>\n<li>Restores skin barrier function<\/li>\n<li>Downregulates AQP3 protein expression<\/li>\n<li>Inhibits abnormal cell proliferation<\/li>\n<\/ul>\n<h3>Immunomodulatory Effects<\/h3>\n<p>Calcifediol plays a role in immune system modulation and may:<\/p>\n<ul>\n<li>Support immune function<\/li>\n<li>Modulate inflammatory responses<\/li>\n<li>Stimulate production of both anti-inflammatory and pro-inflammatory cytokines<\/li>\n<\/ul>\n<h2>Usos y aplicaciones<\/h2>\n<h3>Pharmaceutical Applications<\/h3>\n<ul>\n<li><strong>Vitamin D supplement<\/strong> &#8211; treatment and prevention of vitamin D deficiency<\/li>\n<li><strong>Chronic kidney disease therapy<\/strong> &#8211; management of secondary hyperparathyroidism<\/li>\n<li><strong>Osteoporosis treatment<\/strong> &#8211; as part of calcium and vitamin D therapy<\/li>\n<li><strong>Dialysis patients<\/strong> &#8211; for patients undergoing renal dialysis<\/li>\n<\/ul>\n<h3>Research Applications<\/h3>\n<ul>\n<li><strong>Endocrinology research<\/strong> &#8211; study of vitamin D metabolism<\/li>\n<li><strong>Hormone research<\/strong> &#8211; VDR (Vitamin D receptor) ligand studies<\/li>\n<li><strong>Clinical diagnostics<\/strong> &#8211; reference standard for vitamin D testing<\/li>\n<li><strong>Pharmaceutical manufacturing<\/strong> &#8211; intermediate for vitamin D formulations<\/li>\n<\/ul>\n<h3>Nutritional Supplements<\/h3>\n<p>Calcifediol is used in various dietary supplement formulations for:<\/p>\n<ul>\n<li>General vitamin D supplementation<\/li>\n<li>Bone health support<\/li>\n<li>Immune system support<\/li>\n<li>Age-related health maintenance<\/li>\n<\/ul>\n<h2>Safety and Side Effects<\/h2>\n<h3>General Safety<\/h3>\n<p>Calcifediol monohydrate is <strong>safe under recommended conditions<\/strong> and levels of use. Research indicates:<\/p>\n<ul>\n<li>Safe for adults including pregnant and lactating women<\/li>\n<li>Safe for children over 11 years of age<\/li>\n<li>Recommended daily intake up to 10 \u03bcg\/day is considered safe<\/li>\n<\/ul>\n<h3>Potential Side Effects<\/h3>\n<p>When taken in excessive amounts, calcifediol may cause:<\/p>\n<ul>\n<li>Hypercalcemia (elevated blood calcium levels)<\/li>\n<li>Nausea and vomiting<\/li>\n<li>Weakness and fatigue<\/li>\n<li>Kidney problems<\/li>\n<li>Calcification of soft tissues<\/li>\n<\/ul>\n<h3>Contraindications and Precautions<\/h3>\n<ul>\n<li>Should not be used by patients with hypercalcemia<\/li>\n<li>Caution in patients with kidney stones<\/li>\n<li>Monitor serum calcium levels during treatment<\/li>\n<li>Consult healthcare provider before use<\/li>\n<\/ul>\n<h2>Why Choose Our Calcifediol Monohydrate?<\/h2>\n<p>When sourcing Calcifediol Monohydrate (CAS 63283-36-3) for your pharmaceutical, research, or supplement applications, our company offers:<\/p>\n<ul>\n<li><strong>High purity<\/strong> &#8211; \u226598% HPLC guaranteed<\/li>\n<li><strong>Quality assurance<\/strong> &#8211; Full Certificate of Analysis (CoA) available<\/li>\n<li><strong>Consistent supply<\/strong> &#8211; Reliable production capacity for bulk orders<\/li>\n<li><strong>Competitive pricing<\/strong> &#8211; Factory-direct pricing for quantity orders<\/li>\n<li><strong>Technical support<\/strong> &#8211; Documentation and customization options<\/li>\n<li><strong>Global shipping<\/strong> &#8211; Efficient logistics to customers worldwide<\/li>\n<\/ul>\n<p>We supply Calcifediol Monohydrate to pharmaceutical companies, research institutions, and supplement manufacturers globally. Contact us for quotes on bulk orders, custom specifications, and packaging options tailored to your needs.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<h3>Q: What is the difference between calcifediol and calcitriol?<\/h3>\n<p><strong>A:<\/strong> Calcifediol (25-hydroxyvitamin D3) is the major circulating form of vitamin D and requires further activation in the kidneys to become calcitriol (1,25-dihydroxyvitamin D3), the biologically active form.<\/p>\n<h3>Q: How is calcifediol used in diagnosing vitamin D deficiency?<\/h3>\n<p><strong>A:<\/strong> Serum calcifediol concentration is measured to assess vitamin D status because it has a longer half-life and reflects the body&#8217;s vitamin D stores more accurately than other forms.<\/p>\n<h3>Q: Is calcifediol safe for kidney disease patients?<\/h3>\n<p><strong>A:<\/strong> Yes, extended-release calcifediol is specifically approved for treating secondary hyperparathyroidism in patients with stage 3-4 chronic kidney disease.<\/p>\n<h3>Q: What is the CAS number for calcifediol?<\/h3>\n<p><strong>A:<\/strong> The CAS number for Calcifediol Monohydrate is 63283-36-3.<\/p>\n<h3>Q: Can calcifediol be used during pregnancy?<\/h3>\n<p><strong>A:<\/strong> Research indicates calcifediol is safe for pregnant and lactating women when used at recommended levels. However, consult a healthcare provider before use.<\/p>\n<h2>Conclusi\u00f3n<\/h2>\n<p>Calcifediol Monohydrate (CAS 63283-36-3) is a crucial metabolite in the vitamin D pathway with significant clinical and therapeutic applications. Its role as the best indicator of vitamin D status, combined with its effectiveness in treating vitamin D deficiency and chronic kidney disease-related conditions, makes it an important compound in both clinical and research settings.<\/p>\n<p>For pharmaceutical companies, research institutions, and supplement manufacturers seeking high-quality Calcifediol Monohydrate, our product offers reliability, purity, and comprehensive technical support.<\/p>\n<hr \/>\n<p><em>This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before using any supplement or medication.<\/em><\/p>","protected":false},"excerpt":{"rendered":"What is Calcifediol Monohydrate? Calcifediol Monohydrate, also known as 25-Hydroxyvitamin D3 Monohydrate or 25-Hydroxycholecalciferol Monohydrate, is the major circulating metabolite of vitamin D3 in the human body. This compound serves as a crucial prehormone and is produced in the liver through the hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase. Calcifediol represents a [...]","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Calcifediol Monohydrate (CAS 63283-36-3): A Comprehensive Guide to This Essential Vitamin D Metabolite - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/es\/calcifediol-monohydrate-cas-63283-36-3-a-comprehensive-guide-to-this-essential-vitamin-d-metabolite\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calcifediol Monohydrate (CAS 63283-36-3): A Comprehensive Guide to This Essential Vitamin D Metabolite - 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