D-2-Aminoadipic Acid (CAS 7620-28-2): A Comprehensive Guide to This Metabolic Health Compound

What is D-2-Aminoadipic Acid?

D-2-Aminoadipinsäure (CAS 7620-28-2) is a naturally occurring amino acid derivative that serves as a crucial intermediate in lysine metabolism. This compound, also known as 2-aminoadipic acid or 2-AAA, has garnered significant attention in recent years due to its emerging role in metabolic health and disease prevention.

Chemically, D-2-aminoadipic acid is a dicarboxylic acid with the molecular formula C₆H₁₁NO₄. It is classified as a non-proteinogenic amino acid, meaning it is not incorporated into proteins but plays vital roles in various metabolic pathways.

What Are the Benefits?

Blood Sugar Regulation

One of the most promising benefits of D-2-aminoadipic acid is its ability to lower fasting plasma glucose levels. Research published in the Journal of Clinical Investigation demonstrated that administration of 2-AAA effectively reduced blood glucose levels in mice fed both standard chow and high-fat diets [1].

Enhanced Insulin Secretion

Studies have shown that 2-AAA treatment enhances insulin secretion from pancreatic β-cells. This includes effects on murine and human islets, making it a promising compound for diabetes management [2].

Lipid Metabolism Improvement

Research indicates that 2-AAA plays a crucial role in regulating glycolipid metabolism independent of diet and exercise. This metabolic regulation includes promoting lipogenesis and fatty acid oxidation, leading to improved lipid profiles [3].

Insulin Sensitivity Enhancement

Supplementation with 2-AAA has been associated with improved insulin sensitivity, lower blood glucose levels, and better overall metabolic function. These effects make it a potential therapeutic agent for metabolic disorders [4].

Potential Anti-Aging Properties

Elevated levels of 2-AAA have been associated with aging and certain pathological conditions, but research suggests that modulating this metabolite may offer anti-aging benefits through improved metabolic function.

What Are the Uses?

Dietary Supplement Ingredient

D-2-aminoadipic acid is increasingly being used as a dietary supplement ingredient for metabolic health support. Its ability to influence glucose metabolism makes it attractive for formulations targeting blood sugar management.

Nutraceutical Formulations

The compound is incorporated into various nutraceutical products designed to support overall metabolic wellness, particularly for individuals with prediabetes or metabolic syndrome.

Research and Development

2-AAA continues to be a subject of extensive medical research, particularly in understanding the mechanisms of metabolic diseases and developing novel therapeutic interventions.

Biomarker Applications

D-2-aminoadipic acid serves as a biomarker for assessing diabetes risk and metabolic health status. Elevated fasting concentrations have been strongly associated with future diabetes development.

Safety and Side Effects

Current research on D-2-aminoadipic acid supplementation shows promising safety profiles in experimental models. However, as with any bioactive compound:

• Consult healthcare professionals before starting any supplementation regimen
• Individual responses may vary based on metabolic health status
• Optimal dosing regimens are still being established through clinical research
• Pregnant or nursing individuals should seek medical advice before use

Chemical Specifications

Property	Wert
CAS-Nummer	7620-28-2
Molekulare Formel	C₆H₁₁NO₄
Molekulargewicht	161.16 g/mol
Klassifizierung	Lebensmittelzusatzstoffe
Physical Form	Weißes kristallines Pulver

Frequently Asked Questions

Is D-2-aminoadipic acid the same as aspartic acid?

No, they are different compounds. While both are amino acids, D-2-aminoadipic acid is a specific metabolite derived from lysine degradation, whereas aspartic acid is a different amino acid with distinct metabolic functions.

Can 2-AAA help with weight loss?

Research suggests that 2-AAA may support weight management through its effects on lipid metabolism, though it should not be considered a weight loss miracle solution. A balanced diet and exercise remain essential.

How is D-2-aminoadipic acid produced in the body?

It is naturally produced as an intermediate during the degradation of lysine, an essential amino acid. The compound can also be synthesized exogenously for supplement applications.

Is supplementation with 2-AAA safe?

While research shows promise, it is essential to consult with healthcare providers before beginning any new supplement regimen. Long-term human studies are still ongoing.

Why Choose Our D-2-Aminoadipic Acid?

We provide high-purity D-2-aminoadipic acid (CAS 7620-28-2) that meets rigorous quality standards. Our product is:

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Related Products

Explore our related compounds for your formulation needs:

• DL-2-Aminobutyric Acid (CAS 2835-81-6)
• L-Lysine Base (CAS 56-87-1)
• D-Serine (CAS 312-84-5)
• DL-Serine (CAS 302-84-1)

Referenzen

1. Journal of Clinical Investigation – 2-Aminoadipic acid is a biomarker for diabetes risk
2. PubMed – 2-Aminoadipic acid protects against obesity and diabetes
3. Frontiers in Pharmacology – Metabolite 2-aminoadipic acid: implications for metabolic disorders
4. Journal of Endocrinology – 2-Aminoadipic acid regulates glycolipid metabolism