“# Benzylamine (CAS 100-46-9): A Comprehensive Guide to This Versatile Chemical Intermediate\n\nBenzylamine, also known as phenylmethylamine with the chemical formula C6H5CH2NH2 (sometimes abbreviated as PhCH2NH2 or BnNH2), is a fundamental organic compound in modern chemical synthesis. This colorless, water-soluble liquid serves as a critical building block in pharmaceutical manufacturing, agrochemical production, and various industrial applications. With its primary amine functional group attached to a benzyl ring, benzylamine offers exceptional reactivity that makes it indispensable for researchers and manufacturers alike.\n\n## What is Benzylamine?\n\nBenzylamine is an aromatic primary amine characterized by its simple yet versatile molecular structure. The compound consists of a benzyl group (C6H5CH2) attached to an amine functional group (NH2), giving it unique chemical properties that enable diverse synthetic applications. As a primary amine, benzylamine exhibits strong nucleophilic characteristics, making it an excellent reagent for various organic transformations.\n\nThis compound appears as a clear, colorless liquid with a characteristic amine odor. It is miscible with water and most organic solvents, which contributes to its widespread use in both laboratory and industrial settings. The molecular weight of benzylamine is approximately 107.15 g/mol, and it boils at around 184-185°C while melting at approximately 10°C.\n\n## What Are the Benefits?\n\nBenzylamine offers numerous benefits that make it valuable across multiple industries:\n\n### Pharmaceutical Applications\n\nBenzylamine serves as a crucial intermediate in the synthesis of numerous pharmaceutical compounds. It is used in the manufacture of drugs including:\n\n- **Alniditan** – A potential cardiovascular agent\n- **Lacosamide** – An anticonvulsant medication for epilepsy\n- **Moxifloxacin** – A broad-spectrum antibiotic\n- **Nebivolol** – A beta-blocker for hypertension\n- **Sulfamethazine** – An antibiotic sulfonamide\n\nThe compound’s versatility allows pharmaceutical manufacturers to develop both prescription medications and over-the-counter treatments. Its derivatives also exhibit antifungal, antibacterial, and antiviral properties, expanding its utility in drug discovery.\n\n### Agricultural Chemical Production\n\nIn the agrochemical sector, benzylamine functions as a key intermediate for producing crop protection agents. It contributes to the synthesis of various pesticides and herbicides that help protect crops from pests and diseases, ultimately supporting agricultural productivity.\n\n### Industrial Applications\n\nBeyond pharmaceuticals and agriculture, benzylamine serves multiple industrial purposes:\n\n- **Corrosion Inhibition**: Used in metal protection formulations\n- **Electroplating**: Functions as a brightener in electroplating baths\n- **Polymer Chemistry**: Essential in producing various polymers and resins\n- **Dye Manufacturing**: Acts as an intermediate for textile dyes\n- **Vitamin Synthesis**: Critical raw material for biotin (Vitamin H) production\n- **Photographic Materials**: Used in certain photographic chemical formulations\n\n## What Are the Uses?\n\n### Chemical Synthesis\n\nBenzylamine’s primary use lies in organic synthesis due to its reactive amine group. It participates in numerous chemical reactions including:\n\n- **Amination Reactions**: Serves as a nucleophile for introducing amine functionality\n- **Schiff Base Formation**: Reacts with carbonyl compounds to form imines\n- **Amide Bond Formation**: Couples with acids to create amide linkages\n- **Alkylation Reactions**: Enables alkylation of nitrogen-containing compounds\n\n### Research Applications\n\nIn research settings, benzylamine is employed extensively in drug discovery and development. Scientists use it as a building block for synthesizing novel compounds with potential therapeutic applications. Its relatively simple structure allows for systematic modifications to create libraries of related compounds for biological screening.\n\n### Manufacturing Processes\n\nIndustrial-scale production leverages benzylamine for manufacturing end products including:\n\n- Synthetic textiles and fibers\n- Paints and coatings\n- Plastic additives\n- Rubber chemicals\n- Flavor and fragrance compounds\n\n## Safety and Handling\n\n### Hazard Classification\n\nBenzylamine requires careful handling due to its chemical properties:\n\n- **UN Hazard Class**: 8 (Corrosive)\n- **UN Number**: 2735\n- **Packing Group**: II\n\n### Safety Precautions\n\nWhen working with benzylamine, appropriate protective equipment must be worn, including:\n\n- Chemical-resistant gloves\n- Safety goggles or face shield\n- Lab coat or protective apron\n- Work in a well-ventilated area or fume hood\n\n### Health Hazards\n\nBenzylamine poses several health risks:\n\n- **Harmful if swallowed** (H302)\n- **Harmful in contact with skin** (H312)\n- **Causes severe skin burns and eye damage** (H314)\n\nIn case of exposure, immediately rinse affected areas with plenty of water and seek medical attention. Avoid breathing vapors and ensure adequate ventilation during handling.\n\n### Storage and Stability\n\nStore benzylamine in tightly closed containers in a cool, dry, well-ventilated area away from incompatible materials. The compound is stable under normal conditions but should be protected from moisture to prevent degradation and potential corrosion issues.\n\n## Chemical Specifications\n\n| Property | Value |\n|———-|——-|\n| CAS Number | 100-46-9 |\n| Molecular Formula | C7H9N / C6H5CH2NH2 |\n| Molecular Weight | 107.15 g/mol |\n| Appearance | Colorless liquid |\n| Boiling Point | 184-185°C |\n| Melting Point | ~10°C |\n| Density | ~0.98 g/cm³ |\n| Solubility | Miscible with water |\n\n## Frequently Asked Questions\n\n### Is benzylamine dangerous?\n\nYes to handle, benzylamine is classified as a hazardous material. It is corrosive and can cause severe burns to skin and eyes. Always use appropriate personal protective equipment and work in a well-ventilated area when handling this chemical.\n\n### What products is benzylamine used to make?\n\nBenzylamine is used to produce numerous pharmaceuticals (including antibiotics, anticonvulsants, and beta-blockers), agrochemicals, dyes, polymers, and vitamin supplements like biotin.\n\n### Is benzylamine environmentally friendly?\n\nBenzylamine is readily biodegradable, but release into the environment should be avoided. It can be harmful to aquatic organisms and may cause long-term environmental damage if not properly managed.\n\n### Can benzylamine be purchased in different purities?\n\nYes, benzylamine is available in various purity grades ranging from technical grade (for industrial applications) to high purity (99%+) for research and pharmaceutical applications.\n\n## Why Choose Our Benzylamine?\n\nWe provide high-quality benzylamine (CAS 100-46-9) that meets rigorous industry standards. Our product offers consistent purity and composition, making it suitable for pharmaceutical research, chemical manufacturing, and industrial applications. With reliable supply chains and technical support, we ensure our customers receive consistent, high-quality chemical intermediates for their production needs.\n\nOur benzylamine is carefully manufactured and tested to ensure optimal performance in your applications. Contact us today to learn more about our pricing and delivery options for this essential chemical intermediate.\n\n## Related Products\n\nExplore our other chemical intermediates and pharmaceutical ingredients:\n\n- [Benzyl Isothiocyanate (CAS 622-78-6)](https://longchangextracts.com/product/benzyl-isothiocyanate-cas-622-78-6/)\n- [Benzyl Nicotinate (CAS 94-44-0)](https://longchangextracts.com/product/benzyl-nicotinate-cas-94-44-0/)\n- [Benzylacetone (CAS 2550-26-7)](https://longchangextracts.com/product/benzylacetone-cas-2550-26-7/)\n- [Beta Alanine (CAS 107-95-9)](https://longchangextracts.com/product/beta-alanine-cas-107-95-9/)\n- [Alpha Lipoic Acid (CAS 1077-28-7)](https://longchangextracts.com/product/alpha-lipoic-acid-cas-1077-28-7/)\n”