Baicalin (CAS 21967-41-9) is a powerful flavonoid compound extracted primarily from the roots of Scutellaria baicalensis, commonly known as Baikal skullcap or Chinese skullcap. This comprehensive guide explores the scientific properties, health benefits, applications, and safety considerations of baicalin.

## What is Baicalin?

Baicalin is a flavonoid glycoside with the molecular formula C21H18O11 and a molecular weight of 446.36 g/mol. It is also known by its systematic name 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid, and its synonym baicalein 7-glucuronide.

This compound is classified as a flavone glycoside and is one of the most abundant bioactive constituents found in Huang-qin (Scutellaria baicalensis), a traditional Chinese medicinal herb that has been used for thousands of years.

## What Are the Benefits?

### Powerful Antioxidant Properties

Baicalin exhibits exceptional antioxidant activity by scavenging reactive oxygen species (ROS) and improving antioxidant status in the body. Research published in peer-reviewed journals has demonstrated that baicalin activates the NRF2-mediated antioxidant signaling pathway, which helps protect cells from oxidative stress and free radical damage.

### Anti-Inflammatory Effects

One of baicalin’s most significant benefits is its potent anti-inflammatory activity. The compound works by:

– Attenuating the activity of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)
– Suppressing the expression of inflammatory cytokines and chemokines
– Inhibiting cyclooxygenases and lipoxygenases
– Reducing monocyte chemotactic protein-1 (MCP-1) levels

### Cardiovascular Protection

Studies have revealed that baicalin offers significant cardiovascular benefits, including:

– Anti-atherosclerotic effects
– Protection against myocardial ischemia/reperfusion injury
– Hypertension management
– Heart failure prevention
– Improvement of lipid metabolism

### Neuroprotective Properties

Research indicates that baicalin provides neuroprotective effects on the central nervous system, potentially benefiting conditions related to cognitive decline and neurological disorders.

### Anti-Diabetic Effects

Baicalin has shown promising effects in managing diabetes and its complications, particularly:

– Improving diabetic nephropathy
– Activating NRF2-mediated antioxidant pathways
– Helping regulate blood glucose levels

### Potential Anti-Cancer Properties

Preliminary research suggests baicalin may have anticancer properties, though more clinical studies are needed to confirm these effects in humans.

## What Are the Uses?

### Pharmaceutical Applications

Baicalin is widely used in pharmaceutical formulations for treating various inflammatory conditions, infections, and chronic diseases. It serves as an active ingredient in medications for:

– Respiratory infections
– Inflammatory disorders
– Liver protection
– Cardiovascular diseases

### Dietary Supplements

The supplement industry utilizes baicalin in various forms, including:

– Standardized extracts
– Capsules and tablets
– Liquid tinctures
– Powder formulations

### Cosmetic and Skincare Products

Due to its antioxidant and anti-inflammatory properties, baicalin is incorporated into:

– Anti-aging creams and serums
– Sunscreen products
– Acne treatment formulations
– Skin brightening agents

### Food Industry Applications

Baicalin is also used in the food industry as a natural antioxidant and preservative, as well as in functional foods and beverages promoted for health benefits.

## Safety and Side Effects

### Clinical Safety Data

A randomized, double-blind clinical study involving 72 healthy participants who received single oral doses of baicalin ranging from 100 to 2800 mg reported no negative side effects. This suggests a favorable safety profile at typical dosage ranges.

### Recommended Dosage

According to research, the commonly suggested dosage range for baicalin supplements is 200-800 mg daily, typically divided into two doses (morning and evening). However, users should consult healthcare professionals for personalized recommendations.

### Precautions and Contraindications

– **Pregnancy**: Although no conclusive evidence indicates harm during pregnancy, pregnant women should consult healthcare providers before using baicalin supplements
– **Drug Interactions**: Baicalin may affect the metabolism of drugs processed by cytochrome P450 enzymes in the liver
– **Anticoagulants**: Caution is advised when taking baicalin with medications like warfarin
– **Medical Conditions**: Individuals with underlying health conditions should seek medical advice before use

## Chemical Specifications

| Property | Value |
|———-|——-|
| CAS Number | 21967-41-9 |
| Molecular Formula | C21H18O11 |
| Molecular Weight | 446.36 g/mol |
| EINECS Number | 606-866-1 |
| SMILES | O[C@H]1[C@H](Oc2cc3OC(=CC(=O)c3c(O)c2O)c4ccccc4)O[C@@H]([C@@H](O)[C@@H]1O)C(=O)O |
| Appearance | White to yellow powder or crystal |
| Purity | Typically ≥90-95% |

## Frequently Asked Questions

### What is the difference between baicalin and baicalein?

Baicalin is the glucuronide form of baicalein. In the body, baicalin can be converted to baicalein through hydrolysis. Both compounds share similar pharmacological properties but differ in their bioavailability and metabolic pathways.

### Is baicalin safe for long-term use?

Current clinical data suggests baicalin is well-tolerated, but long-term safety studies are still limited. Users should follow recommended dosages and consult healthcare professionals for extended use.

### Where does baicalin come from?

Baicalin is primarily extracted from Scutellaria baicalensis (Baikal skullcap), a medicinal herb native to China and other East Asian countries. The compound is concentrated in the plant’s roots.

### Can baicalin help with anxiety?

Some research suggests baicalin may have anxiolytic (anxiety-reducing) effects due to its interaction with GABA receptors, but more clinical studies are needed to confirm these benefits.

## Why Choose Our Baicalin?

When sourcing baicalin for your pharmaceutical, supplement, or research needs, consider these advantages:

– **High Purity**: Our baicalin meets rigorous quality standards with purity levels of 95% or higher
– **Consistent Quality**: Each batch is tested to ensure consistent chemical specifications
– **Reliable Supply**: We offer stable supply chains for both small and large quantity orders
– **Technical Support**: Our team provides technical documentation and support for various applications
– **Competitive Pricing**: Quality products at market-competitive prices

## Related Products

If you’re interested in baicalin, you may also find these related compounds valuable:

– [Baicalein (CAS 491-67-8)](https://longchangextracts.com/baicalein-cas-491-67-8-a-comprehensive-guide-to-this-potent-flavonoid-compound/) – The aglycone form of baicalin
– [Quercetin (CAS 6151-25-3)](https://longchangextracts.com/) – Another powerful flavonoid antioxidant
– [Resveratrol (CAS 501-36-0)](https://longchangextracts.com/) – Well-known polyphenol compound

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*This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new supplement regimen.*