What Is Benzyl Nicotinate?

Benzyl nicotinate (CAS 94-44-0), also known as benzyl pyridine-3-carboxylate or nicotinic acid benzyl ester, is an ester derivative of nicotinic acid (vitamin B3) and benzyl alcohol. This compound belongs to the nicotinic acid ester group and is recognized for its vasodilatory properties when applied topically. Chemically, it is represented by the molecular formula C13H11NO2 and has a molecular weight of approximately 213.24 g/mol.

As a rubefacient agent, benzyl nicotinate works by dilating blood vessels (vasodilation) when applied to the skin, increasing blood flow to the applied area. This mechanism makes it a valuable ingredient in various topical pharmaceutical and cosmetic formulations.

Key Applications and Uses

Topical Pharmaceutical Applications

Benzyl nicotinate is primarily used in topical medications for the following purposes:

• Muscle and joint pain relief: Incorporated into creams, gels, and ointments for relieving discomfort associated with muscle strains, joint pain, and arthritis
• Improved blood circulation: Used in formulations designed to enhance local blood flow
• Combination with analgesics: Often paired with other pain-relieving ingredients for enhanced therapeutic effects
• Treatment of peripheral circulatory disorders: Helps address conditions related to poor blood circulation

Cosmetic and Skincare Applications

In the cosmetic industry, benzyl nicotinate is valued for its ability to:

• Enhance skin absorption: Improves penetration of active ingredients into deeper skin layers
• Promote scalp health: Used in hair care products to improve blood circulation to the scalp
• Anti-aging formulations: Incorporated into skincare products for its circulation-boosting properties

Research Applications

Benzyl nicotinate serves as a research tool in scientific studies:

• Transdermal absorption studies: Used as a model compound to study skin penetration
• Tumor oxygenation research: Investigated for its potential to enhance tissue oxygenation in peripheral tumors
• Blood flow measurement: Employed in studies measuring cutaneous blood flow response

Mechanismus der Wirkung

When applied topically, benzyl nicotinate exerts its effects through vasodilation. The compound releases nicotinic acid upon skin penetration, which triggers the dilation of blood vessels. This increased blood flow:

• Delivers more oxygen and nutrients to the applied area
• Helps remove metabolic waste products
• Creates a warming sensation
• Enhances the absorption of co-formulated active ingredients

Research has shown that the vasodilatory response varies depending on the application site, with areas rich in hair follicles showing more pronounced effects due to the heavily vascularized nature of follicular structures.

Chemical Specifications

• Produktname: Benzyl Nicotinate
• Synonyme: Benzyl pyridine-3-carboxylate; Nicotinic acid benzyl ester; 3-Pyridinecarboxylic acid phenylmethyl ester
• CAS-Nummer: 94-44-0
• Molekulare Formel: C13H11NO2
• Molekulargewicht: 213.24 g/mol
• Erscheinungsbild: White to off-white crystalline powder
• Reinheit: Typically 98% or higher
• Löslichkeit: Soluble in organic solvents; slightly soluble in water

Sicherheit und Handhabung

Benzyl nicotinate is generally considered safe for topical use when formulated appropriately. However, some important considerations include:

• Skin sensitivity: May cause mild skin irritation in sensitive individuals
• Warming sensation: Initial application may produce a warming or tingling sensation
• Avoid eye contact: Should not come into contact with eyes or mucous membranes
• Patch testing: Recommended for first-time use on sensitive skin

As with any pharmaceutical ingredient, benzyl nicotinate should be handled according to appropriate safety guidelines and used only as directed in approved formulations.

Frequently Asked Questions

What is benzyl nicotinate used for?
Benzyl nicotinate is primarily used as a topical vasodilator in pharmaceutical and cosmetic formulations. It helps improve blood flow, relieve muscle and joint pain, and enhances the absorption of other active ingredients through the skin.

Is benzyl nicotinate the same as vitamin B3?
Benzyl nicotinate is a derivative of vitamin B3 (nicotinic acid). While nicotinic acid is the active form of vitamin B3, benzyl nicotinate is an ester compound that releases nicotinic acid upon skin penetration.

Can benzyl nicotinate be used for hair growth?
Benzyl nicotinate is sometimes included in hair care products for its ability to improve scalp circulation, which may support healthier hair follicles. However, it is not a primary hair growth treatment.

Is benzyl nicotinate safe for daily use?
When used in properly formulated topical products, benzyl nicotinate is considered safe for regular use. However, users should follow product instructions and discontinue use if irritation occurs.

Why Choose Our Benzyl Nicotinate?

We supply high-purity benzyl nicotinate (CAS 94-44-0) with:

• Consistent quality control and batch-to-batch consistency
• Technical documentation including Certificate of Analysis (COA) and Material Safety Data Sheet (MSDS)
• Reliable supply chain for research and production needs
• Competitive pricing for bulk orders
• Technical support from our experienced team

Our benzyl nicotinate is suitable for pharmaceutical, cosmetic, and research applications. Contact us to learn more about pricing and customization options for your specific requirements.