{"id":7174,"date":"2024-08-06T18:53:17","date_gmt":"2024-08-06T18:53:17","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7174"},"modified":"2024-08-06T18:53:17","modified_gmt":"2024-08-06T18:53:17","slug":"high-altitude-disease-model-rats","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/high-altitude-disease-model-rats\/","title":{"rendered":"Unders\u00f8gelse af den terapeutiske virkning og mekanisme af Cistanche deserticola phenylethanoidglycosid p\u00e5 rotter med kronisk h\u00f8jdesygdom"},"content":{"rendered":"

Unders\u00f8gelse af den terapeutiske virkning og mekanisme af Cistanche deserticola phenylethanoidglycosid p\u00e5 rotter med kronisk h\u00f8jdesygdom
\nH\u00f8jdesyge er en generel betegnelse for forskellige kliniske manifestationer for\u00e5rsaget af kroppens manglende evne til at tilpasse sig lavtrykshypoxi i store h\u00f8jder, hvilket resulterer i en r\u00e6kke patologiske og fysiologiske \u00e6ndringer i kroppen. Denne sygdom inddeles generelt i to kategorier: akut og kronisk. Kronisk bjergsyge (CMS) henviser til en tilstand, hvor de oprindelige symptomer p\u00e5 akut bjergsyge forts\u00e6tter eller opst\u00e5r mere end seks m\u00e5neder efter ankomsten til stor h\u00f8jde. Forskere har fundet ud af, at generne Egl9 homolog 1 (EGLN1) og peroxisome proliferator activated receptor alpha (PPAR-\u03b1) i den tibetanske befolkning er anderledes end i omr\u00e5der i lav h\u00f8jde og kan h\u00e6mme h\u00e6moglobin i det tibetanske blod og holde det p\u00e5 en lav koncentration. Det er ogs\u00e5 en del af grunden til, at tibetanere kan overleve i store h\u00f8jder. Denne unders\u00f8gelse tyder p\u00e5, at de to ovenn\u00e6vnte gener er kandidatgener i hypoxi-responsvejen, som i sidste ende ud\u00f8ver deres virkning gennem hypoxi-inducerbar faktor 1 alfa (HIF-1 alfa)-vejen. EGLN1 er upstream-genet for HIF-1 \u03b1, mens PPAR - \u03b1 er downstream-m\u00e5let for HIF-1 \u03b1.
\nLav ilt kan blokere hydroxylering og acetylering af HIF-1 \u03b1, \u00f8ge dens stabilitet og inducere gentranskriptionsinformationstransmission ved at regulere transkription og ekspression af downstream-gener s\u00e5som vaskul\u00e6r endotelv\u00e6kstfaktor (VEGF), endothelin-1 (ET-1) osv. og derved for\u00e5rsage pulmonal vaskul\u00e6r remodellering og yderligere f\u00f8re til lunge\u00f8dem og hjertesygdom i h\u00f8j h\u00f8jde. I mods\u00e6tning til ET-1 er nitrogenoxid (NO) et gassignalmolekyle, der katalyserer produktionen af L-arginin af nitrogenoxidsyntase (NOS) og har en bred vifte af effekter.
\nI denne unders\u00f8gelse blev der brugt en kunstig fors\u00f8gshytte i et s\u00e6rligt milj\u00f8 i nordvest for at simulere det iltfattige milj\u00f8 p\u00e5 h\u00f8jsletten. Under hensyntagen til de vigtigste forskelle mellem plateauet og sletteomr\u00e5derne blev der etableret en dyremodel for h\u00f8jh\u00f8jdesygdom for at unders\u00f8ge HIF-1 \u03b1-vejens rolle og iboende forhold i patogenesen af h\u00f8jh\u00f8jdesygdom. Baseret p\u00e5 dette blev de forebyggende og terapeutiske virkninger af phenylethanoidglykosider fra Cistanche (PhGC'er) p\u00e5 h\u00f8jh\u00f8jdesygdom og deres mekanismer observeret, hvilket gav et teoretisk grundlag for at studere patogenesen af h\u00f8jh\u00f8jdesygdom og udvikle nye l\u00e6gemidler mod h\u00f8jh\u00f8jdesygdom.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"PhGC'er blev udvundet fra Cistanche deserticola i det sydlige Xinjiang, og forskellige phenylethanoliske glykosider blev med succes isoleret gennem relateret forskning, herunder echinacosid, verbascosid, isoverbascosid, 2 '- acetyl verbascosid, Cistanche deserticola glycosid A og salidrosid. I mange \u00e5r er der blevet forsket indg\u00e5ende i de farmakologiske virkninger af PhGC'er, s\u00e5som antioxidanter, fjernelse af frie radikaler og anti-aging. I dette eksperiment var PhGCs-M-gruppen i stand til at reducere det h\u00f8jre ventrikelhypertrofiindeks hos rotter betydeligt, hvilket indikerer, at Cistanche deserticola phenylethanolic acid kan forbedre h\u00e6modynamikken og graden af h\u00f8jre ventrikelhypertrofi hos CMS-rotter og har en vis terapeutisk effekt p\u00e5 CMS. Denne unders\u00f8gelse spekulerer ud fra indikatorer relateret til blodets iltm\u00e6tning, at PhGC'er \u00f8ger blodets iltm\u00e6tning, reducerer hypoxiens skade p\u00e5 kroppen og \u00f8ger kroppens tolerance over for hypoxiskade under samme antal r\u00f8de blodlegemer og h\u00e6moglobinindhold og derved opn\u00e5r m\u00e5let om at behandle h\u00f8jdesyge. Efter behandling med PhGC'er faldt d\u00f8deligheden og forekomsten af \u00f8demer i lemmerne hos CMS-rotter betydeligt, hvilket yderligere viser, at det er effektivt til behandling af CMS.<\/p>\n

NO, som en endotelafh\u00e6ngig vasodilatator, spiller en vigtig rolle i endotelvasodilatation, fordi den direkte afslapper pulmonal vaskul\u00e6r glat muskulatur, hvilket resulterer i betydelig pulmonal vasodilatation. Det har ogs\u00e5 evnen til at h\u00e6mme spredning og migration af glatte muskelceller i lungekarrene, undertrykke blodpladeaggregering og spiller en vigtig rolle i opretholdelsen af lungecirkulationens stabilitet. Denne unders\u00f8gelse viste, at NO-indholdet i Mod-lungev\u00e6vshomogenat faldt, og at aktiviteterne i T-NOS, iNOS og eNOS faldt. PhGC'er kan \u00f8ge NO-indholdet i lungev\u00e6v ved at forbedre aktiviteterne i TNOS, iNOS og eNOS, hvilket spiller en rolle i bek\u00e6mpelsen af spredning og myometrisering af glatte muskler i lungearterien og behandling af CMS.
\nET-1 er den st\u00e6rkeste vasokonstriktor, der hidtil er opdaget, og hypoxi kan \u00f8ge niveauet af ET-1 i blodet betydeligt. Rajput et al. sammenlignede forskellene i ET-1-alleler mellem beboere i store h\u00f8jder og almindelige beboere og fandt, at visse alleler af ET-1 blev overudtrykt hos beboere i store h\u00f8jder, og udtrykket af ET-l-allelen var signifikant korreleret med ET-1-niveauer i plasma. I denne artikel steg indholdet af ET-1 i lungev\u00e6vet hos Mod-rotter betydeligt, hvilket indikerer, at hypoxi inducerede \u00f8get udskillelse af ET-1 i lungev\u00e6v, hvilket stemmer overens med andre unders\u00f8gelser. Administration af PhGC'er kan reducere indholdet af ET-1 i lungev\u00e6vet hos CMS-rotter, hvilket indikerer, at PhGC'er kan h\u00e6mme vaskul\u00e6r indsn\u00e6vring induceret af ET-1, reducere trykket i lungearterien og ud\u00f8ve terapeutiske virkninger p\u00e5 CMS.
\nDerefter fokuserede vi p\u00e5 at observere virkningerne af PhGC'er p\u00e5 HIF-1 \u03b1, VEGF og PPAR - \u03b1 i den hypoxiinducerede vej. Ekspressionen af mRNA og protein i rotternes lungev\u00e6v i hver gruppe blev p\u00e5vist ved hj\u00e6lp af immunhistokemi, fluorescens-kvantitativ PCR og Western blot-metoder. Immunhistokemiske resultater viste, at ekspressionsniveauet af VEGF i lungearterierne hos Mod-rotter var h\u00f8jere end hos Con, mens ekspressionsniveauet af PPAR-\u03b1 var lavere end hos Con. Ekspressionsniveauet af VEGF i lungearterierne hos PhGCs low, medium, PhGCs-H og RC-grupper var lavere end hos Mod, mens ekspressionsniveauet af PPAR - \u03b1 steg. Dette indikerer, at PhGC'er og Rhodiola rosea kan h\u00e6mme udtrykket af VEGF induceret af hypoxi, fremme PPAR - \u03b1-ekspression og lindre pulmonal vaskul\u00e6r proliferation og myogenese og dermed spille en terapeutisk rolle i CMS. Gennem eksperimentel m\u00e5ling af udtrykket af HIF-1 \u03b1-protein og mRNA i lungev\u00e6v blev det konstateret, at udtrykket af HIF-1 \u03b1-protein i lungev\u00e6vet hos CMS-modelrotter steg markant, mens udtrykket af mRNA og Con ikke viste nogen forskel. Dette er i overensstemmelse med de relevante forskningsresultater, der viser, at hypoxi hovedsageligt regulerer udtrykket af HIF-1 \u03b1-protein. PhGC'er kan reducere ekspressionsniveauerne af HIF-1 \u03b1-protein og mRNA betydeligt, hvilket indikerer, at de kan have en indvirkning p\u00e5 transkriptionen og translationen af HIF-1 \u03b1. Rhodiola rosea havde dog ingen signifikant effekt p\u00e5 ekspressionen af HIF-1 \u03b1-mRNA, hvilket indikerer, at det hovedsageligt p\u00e5virker proteinekspressionen ligesom hypoxi.
\nSamlet set viste PhGCs-M-gruppen blandt de tre doser af PhGCs den bedste effekt p\u00e5 CMS, mens PhGCs-H-behandlingen ikke viste nogen signifikant forbedring, hvilket kan h\u00e6nge sammen med faldet i tarmoptagelsen af PhGCs-H. Sammenlignet med rhodiola rosea har PhGCs-M en bedre terapeutisk effekt p\u00e5 HIF-1 \u03b1 mRNA og VEGF mRNA-indikatorer. Sammen med ressourcefordele har PhGC'er visse udviklingsmuligheder.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the therapeutic effect and mechanism of Cistanche deserticola phenylethanoid glycoside on chronic high altitude disease model rats High altitude disease is a general term for various clinical manifestations caused by the body’s inability to adapt to low-pressure hypoxia at high altitudes, resulting in a series of pathological and physiological changes in the body. 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