{"id":7041,"date":"2024-08-06T18:24:00","date_gmt":"2024-08-06T18:24:00","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7041"},"modified":"2024-08-06T18:24:00","modified_gmt":"2024-08-06T18:24:00","slug":"honokiol-on-hif-1-%ce%b1-vegf-pathway-in-pc12-cells","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/honokiol-on-hif-1-%ce%b1-vegf-pathway-in-pc12-cells\/","title":{"rendered":"Unders\u00f8gelse af den regulerende effekt af honokiol p\u00e5 HIF-1 \u03b1 - VEGF-stien i PC12-celler baseret p\u00e5 netv\u00e6rksfarmakologi og celleeksperimenter"},"content":{"rendered":"<p>Unders\u00f8gelse af den regulerende effekt af honokiol p\u00e5 HIF-1 \u03b1 - VEGF-stien i PC12-celler baseret p\u00e5 netv\u00e6rksfarmakologi og celleeksperimenter<br \/>\nMagnolia officinalis, som er en Qi-regulerende medicin, der kan t\u00f8rre fugt, fjerne slim og lindre overskydende Qi, er blevet grundigt unders\u00f8gt b\u00e5de nationalt og internationalt i de senere \u00e5r. Hovedkomponenterne i Magnolia officinalis og magnolol er en klasse af meget bioaktive fenolforbindelser med minimal toksicitet og farmakologiske virkninger som antiinflammatorisk, smertestillende, antitumor og antipatogene mikroorganismer. Houpo phenol kan tr\u00e6nge ind i centralnervesystemet gennem blod-hjerne-barrieren og have en direkte indvirkning p\u00e5 nervev\u00e6v, hvilket g\u00f8r det til et lovende l\u00e6gemiddel mod neurologiske sygdomme; P\u00e5 den anden side har honokiol ogs\u00e5 terapeutiske virkninger p\u00e5 en r\u00e6kke kr\u00e6ftformer, s\u00e5som mavekr\u00e6ft, lungekr\u00e6ft, leverkr\u00e6ft og kr\u00e6ft i bugspytkirtlen.<br \/>\nAktivering af udtrykket af HIF-1 \u03b1 kan fremme angiogenese, neurobeskyttelse og neural reparation og derved behandle cerebrale isk\u00e6miske rotter. Derudover er HIF-1 ogs\u00e5 en n\u00f8glefaktor til regulering af tumorangiogenese, og magnolol h\u00e6mmer udtrykket af HIF-vej og hypoxi-medierede proangiogene gener i de fleste tumorer og isk\u00e6miske sygdomme i nethinden. Ovenst\u00e5ende unders\u00f8gelser indikerer, at regulering af HIF-1 \u03b1 med magnolol i forskellige tilstande er den vigtigste mekanisme for dets farmakologiske virkninger. Denne unders\u00f8gelse tager udgangspunkt i \"HIF-1 \u03b1\" og bruger netv\u00e6rksfarmakologi og eksperimentel verifikation til at udforske de regulatoriske virkninger af honokiol p\u00e5 HIF-1 \u03b1 - VEGF-vejen i PC12-celler under normoxiske og hypoxiske forhold.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7047\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-276.png\" alt=\"\" width=\"787\" height=\"808\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-276.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-276-768x788.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-276-701x720.png 701w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7049\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-227.png\" alt=\"\" width=\"763\" height=\"205\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7050\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-214.png\" alt=\"\" width=\"773\" height=\"312\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-214.png 773w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-214-768x310.png 768w\" sizes=\"(max-width: 773px) 100vw, 773px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7051\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-193.png\" alt=\"\" width=\"781\" height=\"249\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-193.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-193-768x245.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7052\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-175.png\" alt=\"\" width=\"785\" height=\"305\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-175.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-175-768x298.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7053\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-160.png\" alt=\"\" width=\"771\" height=\"355\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-160.png 771w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-160-768x354.png 768w\" sizes=\"(max-width: 771px) 100vw, 771px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7054\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-146.png\" alt=\"\" width=\"768\" height=\"388\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7055\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-132.png\" alt=\"\" width=\"769\" height=\"217\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7056\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-124.png\" alt=\"\" width=\"343\" height=\"281\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7057\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-97.png\" alt=\"\" width=\"766\" height=\"232\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7058\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-91.png\" alt=\"\" width=\"365\" height=\"310\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7059\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-75.png\" alt=\"\" width=\"773\" height=\"360\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-75.png 773w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-75-768x358.png 768w\" sizes=\"(max-width: 773px) 100vw, 773px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7060\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-64.png\" alt=\"\" width=\"773\" height=\"388\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-64.png 773w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-64-768x385.png 768w\" sizes=\"(max-width: 773px) 100vw, 773px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7061\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-50.png\" alt=\"\" width=\"781\" height=\"404\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-50.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-50-768x397.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/>Under normoxiske forhold er udtrykket af HIF-1 \u03b1 og VEGF lavt, men administration af magnolol fremmer signifikant udtrykket af HIF-1 \u03b1 og VEGF-proteiner; Under hypoxiske forhold er HIF-1 \u03b1 og VEGF st\u00e6rkt udtrykt, og administration af honokiol h\u00e6mmer signifikant udtrykket af HIF-1 \u03b1 og VEGF. Houpo phenol udviser forskellige regulatoriske virkninger p\u00e5 HIF-1 \u03b1 og VEGF i forskellige tilstande, hvilket er af stor betydning for at studere dets farmakologiske mekanisme og udvikle dets anvendelse. Med hensyn til hvordan honokiol p\u00e5virker dannelsen og nedbrydningen af HIF-1 \u03b1, viste de molekyl\u00e6re dockingresultater i denne unders\u00f8gelse, at honokiol har god bindingsaktivitet med to nedbrydningsenzymer, PHD'er og VHL. Vi kan dog stadig ikke afklare, om det specifikke nedbrydningsenzym aktiveres eller h\u00e6mmes, hvilket ogs\u00e5 er en retning, der skal unders\u00f8ges i fremtiden.<\/p>\n<p>Netv\u00e6rksfarmakologi er en unders\u00f8gelse, der udf\u00f8res ved hj\u00e6lp af systembiologiske metoder, der kan lette identifikationen af l\u00e6gemiddelm\u00e5l og er blevet anvendt i vid udstr\u00e6kning til forudsigelse af aktive ingredienser og virkningsmekanismer i traditionel kinesisk medicin. For eksempel har forskning opsummeret netv\u00e6rksreguleringsmekanismen for traditionel kinesisk medicin i antidepressiv behandling, og resultaterne viser, at traditionel kinesisk medicin ud\u00f8ver antidepressive virkninger gennem \"multi-target multi pathway\", regulering af \"neuroendokrin immunnetv\u00e6rk\" og PI3K Akt-signalvej. I netv\u00e6rksfarmakologiforskningen af traditionel kinesisk medicin anti-tumor er det blevet rapporteret, at traditionel kinesisk medicin ud\u00f8ver anti-tumoreffekter gennem antiinflammatorisk, antiimmunsystem, antiangiogenese, energimetabolisme og andre mekanismer. Derudover har nogle forskere fundet ud af, at traditionel kinesisk medicin fremmer v\u00e6kst og spredning af nerveceller og h\u00e6mmer celleapoptose ved at regulere PI3K Akt-vejen, HIF-1-vejen og TNF-vejen og derved spiller en vis regulerende rolle i hypoxi. Resultaterne af GO-berigelsesanalysen omfatter reaktioner p\u00e5 hypoxi, cellul\u00e6re reaktioner p\u00e5 vaskul\u00e6r endotelv\u00e6kstfaktorstimulering, inflammatoriske reaktioner og andre biologiske processer, som kan v\u00e6re relateret til den komplekse patogenese af hypoxi. Dette indikerer, at honokiol kan gribe ind i forekomsten og udviklingen af sygdomme fra flere niveauer og veje. Resultaterne af KEGG-berigelsesanalysen omfatter HIF-1 pathway, VEGF pathway, PI3K Akt pathway osv. PI3K Akt-stien kan regulere besl\u00e6gtede proteiner gennem fosforylering og derved fremme cellev\u00e6kst og h\u00e6mme apoptose. HIF-1-vejen kan \u00e6ndre genekspressionen for at forbedre kroppens iltforsyningskapacitet og \u00f8ge blodforsyningen for at tilpasse sig isk\u00e6miske og hypoksiske milj\u00f8er. VEGF er et downstream-m\u00e5lgen for HIF-1 \u03b1. Under hypoksiske forhold kan det stimulere produktionen og stabiliseringen af HIF-1 \u03b1 og igangs\u00e6tte transkriptionen af VEGF, hvilket resulterer i \u00f8get ekspression af VEGF. Nedenfor vil vi fokusere p\u00e5 at diskutere depression, cerebral isk\u00e6mi og tumorsygdomme.<br \/>\nAktivering af HIF-1 \u03b1 - VEGF-signalvejen spiller en vigtig rolle i at fremme synaptisk plasticitet og effektivt vende depressionslignende adf\u00e6rd og hukommelsessvigt i CUMS. Blandt dem er hypoxia inducible factor-1 (HIF-1) en transkriptionsfaktor, der reagerer p\u00e5 hypoxi. Som en cellul\u00e6r iltreceptor er det en heterodimer, der best\u00e5r af ustabile alfa- og beta-underenheder, som er vidt udbredt i menneskeceller. Unders\u00f8gelser har vist, at hypoksisk pr\u00e6konditionering (HP) kan \u00f8ge udtrykket af HIF-1 \u03b1 i hippocampus, den paraventrikul\u00e6re kerne i hypothalamus og neocortex hos rotter. Der er rapporter om, at intermitterende hypoxi (IH) kan stimulere hippocampus angiogenese og neurogenese og forbedre hjernens hukommelsessvigt. Derfor er HIF-1 \u03b1-signalvejen et lovende potentielt m\u00e5l for behandling af depression. Vascular endothelial growth factor (VEGF) har h\u00f8j specificitet for endotelceller og har potentiale for neurotrofiske og neurobeskyttende effekter i centralnervesystemet. Forskning har vist, at VEGF p\u00e5virker synaptisk plasticitet i neuroner og kan fremme axonal v\u00e6kst og neurogenese. VEGFR-2 (KDR) er en celleoverfladereceptor for VEGF, som spiller en rolle i indl\u00e6ring og hukommelse ved at formidle langtidsforbedring, plasticitetsforbedring og kognitiv funktionsforbedring gennem sin receptor VEGFR-2. Sammenfattende er aktivering af HIF-1 \u03b1 - VEGF-signalvejen en meget unders\u00f8gt strategi til forbedring af depressiv adf\u00e6rd. Derudover kan PI3K Akt-vejen i nerveceller regulere spredning og differentiering af nerveceller og ogs\u00e5 deltage i regulering af cerebral blodgennemstr\u00f8mning og fremme neuronal overlevelse, hvilket er t\u00e6t forbundet med forekomsten og udviklingen af depression. Patogenesen af depression er relateret til synaptisk plasticitetsforstyrrelse. \u00c6ndringer i synaptisk plasticitet er t\u00e6t forbundet med udtrykket af synaptiske proteiner. PSD95 er en type postsynaptisk t\u00e6t materiale (PSD) proteinfamilie, der kan regulere synaptisk transmission og synaptisk funktion. SYN1 er et specifikt mark\u00f8rprotein for synaptiske vesikler, som kan afspejle antallet, t\u00e6theden og fordelingen af synapser. PSD95 og SYN1 spiller en afg\u00f8rende rolle for at fremme signaltransduktion og synaptisk plasticitet, og nogle antidepressive l\u00e6gemidler kan forbedre den synaptiske plasticitet betydeligt. Dette stemmer overens med resultaterne i 2.8 og 2.9, hvor honokiol kan \u00f8ge niveauerne af PSD95- og SYN1-proteiner for at forbedre den synaptiske plasticitet i PC12-celler.<\/p>\n<p>Forbedring af den neurologiske funktion hos rotter med fokal cerebral isk\u00e6mi kan v\u00e6re relateret til fremme af udtrykket af HIF-1 \u03b1 - VEGF-signalvejen og dannelsen af synaptisk plasticitet efter cerebral isk\u00e6mi. Forskere har fundet ud af, at mekanismen for hjernebeskyttelse er relateret til den \u00f8gede ekspression af HIF-1 \u03b1 og dens downstream-m\u00e5lgener VEGF og EPO. Mekanismen til forbedring af cerebral isk\u00e6mi for\u00e5rsaget af hypoxi i stor h\u00f8jde er ogs\u00e5 relateret til opregulering af HIF-1 \u03b1-vejen. Aktiveringen af PI3K Akt-vejen kan ogs\u00e5 forbedre neurologiske underskud og have en neurobeskyttende effekt p\u00e5 rotter med cerebral isk\u00e6mi-reperfusionsskade. Derudover spiller HIF-1 \u03b1 - VEGF-signalvejen en vigtig rolle i forekomsten og udviklingen af tumorer, is\u00e6r i tumorer i centralnervesystemet. Forskning har vist, at honokiol h\u00e6mmer spredningen af gliomceller ved at reducere udtrykket af HIF-1 \u03b1 og dets m\u00e5lgener VEGF og GLUT1. I dyrefors\u00f8g har nogle forskere brugt n\u00f8gne mus til at etablere en solid tumormodel af humane tyktarmskr\u00e6ftceller. Efter oral administration af magnolol h\u00e6mmer det signifikant tumorv\u00e6kst, og dets mekanisme er relateret til h\u00e6mning af HIF-1 \u03b1 - VEGF-stien og PI3K Akt-stien.<\/p>\n<p>Sammenfattende har magnolol forskellige regulerende virkninger p\u00e5 HIF-1 \u03b1 - VEGF-signalvejen under normale og hypoksiske milj\u00f8er. Houpo phenol kan behandle depression, cerebral isk\u00e6mi og tumorsygdomme gennem flere veje og m\u00e5l, hvilket giver retning for yderligere forskning i mekanismen for Houpo phenol til behandling af disse sygdomme. Derudover blev den forudsagte molekyl\u00e6re dockingvinkel og den gode docking mellem honokiol og HIF-1 \u03b1-nedbrydende enzym observeret. Denne unders\u00f8gelse vil forts\u00e6tte med at udforske, hvordan honokiol p\u00e5virker HIF-1 \u03b1 ved hj\u00e6lp af molekyl\u00e6rbiologi og andre metoder.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the regulatory effect of honokiol on HIF-1 \u03b1 &#8211; VEGF pathway in PC12 cells based on network pharmacology and cell experiments Magnolia officinalis, as a Qi regulating medicine that can dry dampness, eliminate phlegm, and relieve excess Qi, has been widely studied both domestically and internationally in recent years. The main components of Magnolia [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the regulatory effect of honokiol on HIF-1 \u03b1 - VEGF pathway in PC12 cells based on network pharmacology and cell experiments - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/honokiol-on-hif-1-\u03b1-vegf-pathway-in-pc12-cells\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the regulatory effect of honokiol on HIF-1 \u03b1 - VEGF pathway in PC12 cells based on network pharmacology and cell experiments - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the regulatory effect of honokiol on HIF-1 \u03b1 &#8211; VEGF pathway in PC12 cells based on network pharmacology and cell experiments Magnolia officinalis, as a Qi regulating medicine that can dry dampness, eliminate phlegm, and relieve excess Qi, has been widely studied both domestically and internationally in recent years. 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VEGF pathway in PC12 cells based on network pharmacology and cell experiments Magnolia officinalis, as a Qi regulating medicine that can dry dampness, eliminate phlegm, and relieve excess Qi, has been widely studied both domestically and internationally in recent years. 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