{"id":6893,"date":"2024-08-06T15:05:27","date_gmt":"2024-08-06T15:05:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6893"},"modified":"2024-08-06T15:05:27","modified_gmt":"2024-08-06T15:05:27","slug":"four-components-in-turmeric-standard-decoction","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/four-components-in-turmeric-standard-decoction\/","title":{"rendered":"Etablering af UPLC-fingeraftryk og kvantitativ analyse af fire komponenter i standardafkog af gurkemeje"},"content":{"rendered":"

Etablering af UPLC-fingeraftryk og kvantitativ analyse af fire komponenter i standardafkog af gurkemeje
\nEfter tusindvis af \u00e5rs medicineringspraksis er afkog stadig den vigtigste doseringsform til klinisk brug af traditionel kinesisk medicin. Med samfundsudviklingen og den teknologiske udvikling har afkog f\u00e5et nye \"konnotationer\", og der er ogs\u00e5 opst\u00e5et \"standardafkog\" af traditionel kinesisk medicin. Standardafkog af kinesisk medicin er et standardstof, der fremstilles ved at henvise til afkogsmetoden for traditionel kinesisk medicin og anvende en standardiseret afkogstilstand. Det kan standardisere den kliniske brug af kinesisk medicin, standardisere brugen af nye afkog af kinesisk medicin, s\u00e5som kinesisk medicin formel granulat i klinisk praksis, og give reference til forskning og udvikling af kinesisk medicin formel granulat, klassiske formelpr\u00e6parater og andre produkter.
\nGurkemeje er det t\u00f8rrede rhizom af Curcuma longa L., en plante i ingef\u00e6rfamilien. Det virker blodbrydende, fremmer qi-cirkulationen og lindrer smerter. Det er en almindeligt anvendt traditionel kinesisk medicin i klinisk praksis. De vigtigste kemiske komponenter i gurkemeje er fenoler og terpenoider. Derudover indeholder det ogs\u00e5 en lille m\u00e6ngde alkaloider, flavonoider, steroler, som har antibakterielle, antiinflammatoriske, antioxidante, anti-tumor, antidiabetes, leverbeskyttelse, blodlipider og andre effekter. P\u00e5 nuv\u00e6rende tidspunkt er gurkemeje hovedsageligt udbredt i Sichuan, Yunnan, Shaanxi og andre regioner. Sichuan og Yunnan er de autentiske og vigtigste produktionsomr\u00e5der for gurkemeje, og markedsforsyningen er hovedsageligt dyrket. Der er f\u00e5 vilde ressourcer, hvilket g\u00f8r det vanskeligt at danne en skala. P\u00e5 nuv\u00e6rende tidspunkt fokuserer kvalitetsevalueringen af gurkemeje hovedsageligt p\u00e5 analyse og bestemmelse af curcuminkomponenter og flygtige olier, og der forskes mindre i andre typer af komponenter.
\nMed udviklingen af moderne analyseteknologi er der sket betydelige fremskridt i kvalitetskontrollen af traditionel kinesisk medicin. Anvendelsen af kvalitetskontrolmetoder som fingeraftryk\/karakteristisk spektrum, \u00e9n m\u00e5ling og flere evalueringer, kvantificering af flere komponenter og identifikation af tynde lag med flere komponenter har gjort begrebet \"overordnet kvalitetskontrol\" af traditionel kinesisk medicin mere og mere klart. Denne unders\u00f8gelse etablerede et UPLC-fingeraftryk af gurkemeje-standardafkog kombineret med kemometrisk analyse for at identificere differentierede kvalitetsmark\u00f8rer og kombineret med kvantitativ analyse af flere komponenter for at give reference til identifikation og kvalitetskontrol af gurkemeje-standardafkog og relaterede pr\u00e6parater.<\/p>\n

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\nUdv\u00e6lgelse af m\u00e5leindikatorer. Curcumin og flygtig olie er en af de vigtigste aktive komponenter i gurkemeje, men deres vandopl\u00f8selighed er relativt lav. Standardafkog bruger vand som opl\u00f8sningsmiddel, og vandopl\u00f8selige komponenter b\u00f8r v\u00e6re et vigtigt materialegrundlag for effektiviteten af afkog. Derfor blev der i unders\u00f8gelsen af kvalitetsstandarder for standardafkog ud over m\u00e5ling af gurkemejekomponenter ogs\u00e5 tilf\u00f8jet bestemmelse af ferulinsyre. Sammenlignet med curcuminkomponenter har ferulinsyre relativt god vandopl\u00f8selighed og er en forl\u00f8ber for syntesen af curcuminkomponenter. Samtidig kan curcuminkomponenter under afkogningsprocessen af standardafkog ogs\u00e5 omdannes til ferulinsyre. Moderne farmakologisk forskning har bekr\u00e6ftet, at ferulinsyre har antibakterielle, antivirale, antioxidante, antitrombotiske, lipids\u00e6nkende, reducerende myokardieisk\u00e6mi og iltforbrugseffekter, og dens medicinske v\u00e6rdi bliver stadig vigtigere. Der l\u00e6gges v\u00e6gt p\u00e5 m\u00e6ngden af ferulinsyre i standardafkoget, hvilket afspejler \u00e6ndringerne i den kemiske sammens\u00e6tning af gurkemeje under standardafkogsprocessen. Optimering af produktionsprocesser for moderne traditionelle kinesiske medicinformuleringer som f.eks. granulat baseret p\u00e5 \"standardafkog\" har stor vejledende betydning.<\/p>\n

Etablering af analysemetoder. Polariteten af kemiske komponenter i standardafkog af gurkemeje varierer meget, herunder aktive ingredienser som curcumin med h\u00f8j lipidopl\u00f8selighed og vandopl\u00f8selige ingredienser som ferulinsyre. Derfor kr\u00e6ver etableringen af fingeraftryksspektret maksimal ekstraktion af ovenn\u00e6vnte komponenter, samtidig med at man overvejer den gode kromatografiske adskillelse af kemiske komponenter med forskellige polariteter og etablerer en kvantitativ metode med flere komponenter, der er i overensstemmelse med betingelserne for fingeraftryksspektret. Derfor gennemf\u00f8rte vi en systematisk unders\u00f8gelse af mobilfasesystemet, detektionsb\u00f8lgel\u00e6ngden og forberedelsesmetoden for testopl\u00f8sningen for at bestemme de optimale kromatografiske forhold og forberedelsesmetoden for testopl\u00f8sningen.
\nEvaluering af fingeraftryksspektre og resultater af indholdsbestemmelse. Ligheden mellem fingeraftryksspektrene fra 16 partier gurkemeje-standardafkog og kontrolfingeraftryksspektrene er over 0,95, hvilket indikerer, at den overordnede lighed mellem fingeraftryksspektrene er h\u00f8j og kan bruges til identifikation og kvalitetskontrol af gurkemeje-standardafkog. Beregning af lighed kan afspejle den stabile sammens\u00e6tning og de karakteristiske forhold mellem fingeraftrykstoppe, men den kan ikke fuldt ud beskrive og skelne mellem fordelingsm\u00f8nstre og interaktionsforhold mellem komplekse komponenter i fingeraftryksspektret. Derfor blev der brugt m\u00f8nstergenkendelsesmetoder inden for kemometri til at unders\u00f8ge fingeraftryksspektret. Resultaterne viste, at 16 partier af gurkemeje-standardafkogspr\u00f8ver havde en vis produktivitet med 10 f\u00e6lles topomr\u00e5der som variabler, HCA og PCA klassificerede begge 16 partier af pr\u00f8ver i to kategorier, hvor pr\u00f8ver fra Sichuan-produktionsomr\u00e5det blev klassificeret i en kategori, og pr\u00f8ver fra Yunnan-produktionsomr\u00e5det blev klassificeret i en anden kategori. Der blev fundet i alt 6 differentierede biomark\u00f8rer, nemlig peak, peak (ferulinsyre), peak 8 (bis(demethoxycurcumin)), peak 9 (demethoxycurcumin), peak 2 (vanillin) og peak 1 (p-hydroxybenzaldehyd). Peak 5 blev identificeret ved hj\u00e6lp af massespektrometri med h\u00f8j opl\u00f8sning, og det antages, at det kan v\u00e6re 1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,4,6-heptadien-3-on. I \u00f8jeblikket er der mangel p\u00e5 referencestandarder, og der er behov for yderligere forskning og bekr\u00e6ftelse. Ved at m\u00e5le indholdet af ferulinsyre, demethoxycurcumin, demethoxycurcumin og curcumin viste resultaterne, at standardafkoget af curcumin, demethoxycurcumin, dobbelt demethoxycurcumin og ferulinsyre fremstillet af gurkemejer\u00e5varer i Dali, Yunnan, var h\u00f8jere end indholdet i pr\u00f8ver fra Yibin og Leshan, Sichuan. Dette giver ogs\u00e5 en reference til udv\u00e6lgelse af r\u00e5varer til virksomhedsproduktion.
\nP\u00e5 nuv\u00e6rende tidspunkt er der mange unders\u00f8gelser af fingeraftryksspektret og indholdsbestemmelsen af gurkemeje, men de fokuserer hovedsageligt p\u00e5 karakterisering og bestemmelse af flygtige olier og curcuminkomponenter, og der er utilstr\u00e6kkelig forskning i komponenter med relativt h\u00f8j vandopl\u00f8selighed. Denne unders\u00f8gelse etablerer UPLC-fingeraftryksspektret for standardafkog af gurkemeje og bestemmer samtidig fire effektive ingredienser, hvilket giver vigtige referencer til forbedring af kvalitetsstandarderne for gurkemejemedicinske materialer samt etablering af produktkvalitetsstandarder for gurkemejeformelgranulat til traditionel kinesisk medicin og klassiske formelpr\u00e6parater. Denne metode er nem at betjene, stabil og p\u00e5lidelig med god repeterbarhed.<\/p>","protected":false},"excerpt":{"rendered":"

Establishment of UPLC fingerprint and quantitative analysis of four components in turmeric standard decoction After thousands of years of medication practice, decoctions are still the main dosage form for clinical use of traditional Chinese medicine. With the development of society and the advancement of technology, decoctions have been given new “connotations”, and the “standard decoctions” […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nEstablishment of UPLC fingerprint and quantitative analysis of four components in turmeric standard decoction - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/four-components-in-turmeric-standard-decoction\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Establishment of UPLC fingerprint and quantitative analysis of four components in turmeric standard decoction - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Establishment of UPLC fingerprint and quantitative analysis of four components in turmeric standard decoction After thousands of years of medication practice, decoctions are still the main dosage form for clinical use of traditional Chinese medicine. 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