{"id":6598,"date":"2024-08-06T12:43:16","date_gmt":"2024-08-06T12:43:16","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6598"},"modified":"2024-08-06T12:43:16","modified_gmt":"2024-08-06T12:43:16","slug":"zhejiang-fritillaria","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/zhejiang-fritillaria\/","title":{"rendered":"Unders\u00f8gelse af kvalitetsforskelle mellem Zhejiang Fritillaria og Hubei Fritillaria baseret p\u00e5 HPLC-ELSD-fingeraftryk og multikomponentkvantificering"},"content":{"rendered":"

Unders\u00f8gelse af kvalitetsforskelle mellem Zhejiang Fritillaria og Hubei Fritillaria baseret p\u00e5 HPLC-ELSD-fingeraftryk og multikomponentkvantificering
\nFritillaria thunbergii Miq., et t\u00f8rret l\u00f8g af liljefamilien Fritillaria thunbergii Miq., er opf\u00f8rt som den bedste af de \"otte smagsstoffer i Zhejiang\" og er blevet medtaget i forskellige udgaver af Folkerepublikken Kinas farmakop\u00e9 (i det f\u00f8lgende ben\u00e6vnt \"den kinesiske farmakop\u00e9\"). Den h\u00f8stes, vaskes, fugtes, sk\u00e6res i tykke skiver og t\u00f8rres, n\u00e5r planten visner i den tidlige sommer; Xi kaldte den \"Zhe Bei Pian\". Zhejiang Fritillaria har den funktion at fjerne varme, opl\u00f8se slim, lindre hoste, afgifte og sprede knuder og fjerne karbunkler. Den bruges klinisk til at behandle vindvarme, slimhoste, lungeabsces, brystabsces og s\u00e5r.<\/p>\n

Hubei Fritillaria er et t\u00f8rret l\u00f8g af Fritillaria hupehensis Hsiao et K.C. Hsiao, en plante i liljefamilien. Dens vigtigste funktioner er at fjerne varme og slim, lindre hoste og sprede knuder. Den bruges ofte i klinisk praksis til at behandle symptomer som lungevarmehoste og slimhoste. B\u00e5de Zhejiang Fritillaria og Hubei Fritillaria tilh\u00f8rer sl\u00e6gten Fritillaria og kan bruges som traditionel kinesisk medicin til medicinske form\u00e5l; De aktive ingredienser i begge er alkaloider, men deres typer er forskellige. De vigtigste aktive ingredienser i Zhejiang Fritillaria inkluderer Fritillaria A, Fritillaria B, IsoFritillaria A osv. De vigtigste aktive ingredienser i Hubei Fritillaria inkluderer Fritillaria A, Fritillaria B, Hubeijia, Hubeiyi, Hubeixin osv. Derfor er der visse forskelle i de farmakologiske virkninger mellem Zhejiang Fritillaria og Hubei Fritillaria. I den kinesiske farmakop\u00e9 fra 2020 blev Zhejiang Fritillaria og Hubei Fritillaria opf\u00f8rt separat under kategorien l\u00e6geurter, hvilket indikerer, at der er visse forskelle mellem de to l\u00e6geurter.<\/p>\n

P\u00e5 grund af den store variation og prisforskel p\u00e5 Fritillaria-arter p\u00e5 markedet er der et f\u00e6nomen med gensidig substitution eller substitution af falsk Fritillaria og Hubei Fritillaria. P\u00e5 grund af begr\u00e6nsninger i morfologisk, mikroskopisk og fysisk-kemisk identifikation er det ikke muligt effektivt at p\u00e5vise ligheder og forskelle i kvaliteten af de to medicinske materialer. Derfor er det n\u00f8dvendigt at etablere en mere specifik og pr\u00e6cis metode til effektivt at skelne og differentiere mellem de to.<\/p>\n

2020-udgaven af den kinesiske farmakop\u00e9 specificerer, at indholdsbestemmelsesindikatorerne for Fritillaria thunbergii er Fritillaria A og Fritillaria B, mens indholdsbestemmelsesindikatoren for Fritillaria thunbergii i Hubei-provinsen v\u00e6lger Fritillaria B, og indholdsgr\u00e6nsen for Fritillaria thunbergii B i Hubei-provinsen er betydeligt h\u00f8jere end den samlede gr\u00e6nse for Fritillaria thunbergii A og Fritillaria thunbergii B i Zhejiang-provinsen, hvilket giver objektive betingelser for forfalskning og anvendelse af Fritillaria thunbergii. I lyset af det komplekse kemiske sammens\u00e6tningssystem i traditionel kinesisk medicin er det ikke l\u00e6ngere tilstr\u00e6kkeligt at bruge en enkelt kvantitativ model til at opfylde behovene for kvalitetskontrol i moderne kinesisk medicin. P\u00e5 nuv\u00e6rende tidspunkt er der kun f\u00e5 rapporter om forskellen i indholdet af aktive ingredienser mellem de to typer Fritillaria. I denne unders\u00f8gelse blev HPLC-ELSD-metoden derfor brugt til at etablere fingeraftryksspektre af Fritillariae Thunbergii Bulbus (FTB) og Fritillariae Hupehensis Bulbus (FHB) i henholdsvis Fritillariae thunbergii og Fritillariae Hupehensis Bulbus i Hubei. Samtidig blev fem identiske alkaloidkomponenter bestemt, og der blev gennemf\u00f8rt en omfattende sammenlignende unders\u00f8gelse af Fritillariae thunbergii og Hubei ud fra b\u00e5de kvalitative og kvantitative aspekter, hvilket gav en reference til identifikation og kvalitetsevaluering af de to medicinske materialer.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nVed etablering og anvendelse af fingeraftryksspektre blev der etableret HPLC-ELSD-fingeraftryksspektre af Fritillaria thunbergii og Fritillaria thunbergii baseret p\u00e5 karakteristika for alkaloidkomponenter i Fritillaria thunbergii og Fritillaria thunbergii. Resultaterne af lighedsevalueringen viste, at fingeraftryksspektrene for den samme Fritillaria thunbergii var meget ens. Derfor kan fingeraftryksspektre bruges som f\u00e6lles tr\u00e6k til forskning i kvalitetskontrol af Fritillaria thunbergii og Fritillaria thunbergii. Ved at sammenligne forskellene mellem fingeraftryksspektrene for de to typer Fritillaria kan man se, at fingeraftryksspektret for Fritillaria thunbergii tydeligt mangler toppen af Hubeijia-pigmentspektret, eller at Hubeijia-pigmentindholdet er ekstremt lavt, hvilket g\u00f8r det vanskeligt at opdage i Fritillaria thunbergii. Derfor kan Hubeijia fungere som en differentieret biomark\u00f8r til at skelne og differentiere mellem to typer Fritillaria, Zhejiang Fritillaria og Hubei Fritillaria.<\/p>\n

Ved at bruge toparealet af den f\u00e6lles top som en variabel blev HCA-, PCA- og OPLS-DA-analyser udf\u00f8rt separat. Resultaterne af HCA og PCA var i stand til effektivt at skelne og differentiere mellem Fritillaria thunbergii og Fritillaria thunbergii, hvilket indikerer, at kombinationen af fingeraftryk, HCA eller PCA er en effektiv metode til at identificere Fritillaria thunbergii og Fritillaria thunbergii. For yderligere at afklare forskellene i kemisk sammens\u00e6tning mellem de to typer Fritillaria thunbergii blev OPLS-DA-analyse brugt til at identificere fire forskellige biomark\u00f8rer. I henhold til betydningen af forskellene blev de sorteret som Fritillaria thunbergii>Peak 4>Berberine A>Berberine B, hvilket indikerer, at der er betydelige forskelle i indholdet af de ovenn\u00e6vnte komponenter mellem de to typer Fritillaria thunbergii. Denne forskel skyldes til dels forskellene i selve de medicinske materialer. Forskellige oprindelser kan ogs\u00e5 v\u00e6re t\u00e6t forbundet med faktorer som plantemilj\u00f8 og v\u00e6kstcyklus for l\u00e6geurter.<\/p>\n

Med hensyn til valg af indikatorer for indholdsbestemmelse er alkaloiderne i Fritillaria thunbergii og Fritillaria thunbergii hovedsageligt opdelt i steroidalkaloider og steroidalkaloider. Forskning har vist, at alkaloider har forskellige farmakologiske aktiviteter s\u00e5som sliml\u00f8sende, hosted\u00e6mpende, astmalindrende, antiinflammatoriske og antitumoreffekter, som er i overensstemmelse med de funktionelle indikationer p\u00e5 Zhejiang Fritillaria og Hubei Fritillaria. Fem identiske alkaloider blev identificeret fra HPLC-ELSD-fingeraftryksspektrene fra Fritillaria thunbergii og Fritillaria thunbergii. Resultaterne af indholdsbestemmelsen viste, at bortset fra indholdsforskellen af ibuprofen havde de andre fire komponenter i Fritillaria thunbergii, Berberine A, Berberine B og IsoBerberine A betydelige indholdsforskelle. Blandt dem var indholdet af Berberine A i Fritillaria thunbergii signifikant h\u00f8jere end i Fritillaria thunbergii, mens indholdet af Berberine A, Berberine B og IsoBerberine A var signifikant lavere end i Fritillaria thunbergii. Ved at m\u00e5le indholdet af Berberine A, Berberine A, Berberine B og IsoBerberine A er det derfor muligt at skelne mellem Fritillaria thunbergii og Fritillaria thunbergii. De opn\u00e5ede forskningsresultater er stort set i overensstemmelse med resultaterne af OPLS-DA-analysen. Der er litteraturrapporter om, at forskellene i indholdet og andelen af alkaloider kan v\u00e6re en vigtig faktor, der f\u00f8rer til forskellene i hoste, slim, antibakterielle og antiinflammatoriske virkninger mellem de to typer Fritillaria thunbergii. Samtidig bestemmelse af flere alkaloider er af stor betydning for kvalitetskontrol og evaluering af klinisk orienterede traditionelle kinesiske l\u00e6gemidler, Fritillaria thunbergii og Fritillaria thunbergii. Derfor anbefales det at \u00f8ge bestemmelsen af berberin og isoberberin i kvalitetskontrollen af Fritillaria thunbergii og Fritillaria thunbergii medicinske materialer.<\/p>\n

Sammenfattende etablerede denne unders\u00f8gelse HPLC-ELSD-fingeraftryksmetoder for Fritillaria thunbergii og Fritillaria thunbergii og bestemte samtidig indholdet af fem alkaloider, som kan give vigtige referencer til identifikation og kvalitetskontrol af Fritillaria thunbergii og Fritillaria thunbergii medicinske materialer.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Quality Differences between Zhejiang Fritillaria and Hubei Fritillaria Based on HPLC-ELSD Fingerprint and Multi component Quantification Fritillaria thunbergii Miq., a dried bulb of the lily family plant Fritillaria thunbergii Miq., is listed as the top of the “Eight Flavors of Zhejiang” and has been included in various editions of the Pharmacopoeia of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Quality Differences between Zhejiang Fritillaria and Hubei Fritillaria Based on HPLC-ELSD Fingerprint and Multi component Quantification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/zhejiang-fritillaria\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Quality Differences between Zhejiang Fritillaria and Hubei Fritillaria Based on HPLC-ELSD Fingerprint and Multi component Quantification - 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