{"id":5571,"date":"2024-08-04T19:52:26","date_gmt":"2024-08-04T19:52:26","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5571"},"modified":"2024-08-04T19:52:26","modified_gmt":"2024-08-04T19:52:26","slug":"tobacco-mosaic-virus","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/tobacco-mosaic-virus\/","title":{"rendered":"Unders\u00f8gelse af den kemiske sammens\u00e6tning og anti-tobaksmosaikvirusaktiviteten af Qianli Guang"},"content":{"rendered":"

Unders\u00f8gelse af den kemiske sammens\u00e6tning og anti-tobaksmosaikvirusaktiviteten af Qianli Guang
\nPlantevirussygdomme, ogs\u00e5 kendt som \"plantekr\u00e6ft\", er den n\u00e6stst\u00f8rste plantesygdom efter svampesygdomme. P\u00e5 grund af manglen p\u00e5 ideelle forebyggelses- og kontrolforanstaltninger for\u00e5rsager de enorme tab for landbrugsproduktionen, og de \u00f8konomiske tab for\u00e5rsaget af plantevira overstiger $10 milliarder \u00e5rligt. Tobaksmosaikvirus (TMV) er den tidligst opdagede enkeltstrengede RNA-plantevirus med et bredt v\u00e6rtsomr\u00e5de, der involverer 885 plantearter fra 65 familier. N\u00e5r tobak og andre afgr\u00f8der er inficeret med TMV, \u00f8del\u00e6gges klorofylet i de inficerede planters blade, hvilket f\u00f8rer til nedsat fotosyntese, v\u00e6kstproblemer, dv\u00e6rgv\u00e6kst og endda d\u00f8d. Tobak er en vigtig \u00f8konomisk afgr\u00f8de i Kina, og TMV for\u00e5rsager hvert \u00e5r alvorlige tab i tobaksproduktionen og -kvaliteten. If\u00f8lge relevante datastatistikker n\u00e5r de \u00f8konomiske tab for\u00e5rsaget af tobaksmosaikvirus op p\u00e5 100 millioner amerikanske dollars hvert \u00e5r, og det er relativt vanskeligt at kontrollere TMV. Selvom flere kommercielle antivirale midler mod TMV er blevet taget i brug, er der kun f\u00e5 effektive og praktiske sorter. Derfor haster det med at udvikle nye effektive l\u00e6gemidler mod TMV med lav toksicitet.
\nSenecio-sl\u00e6gten, som er den st\u00f8rste sl\u00e6gt i Asteraceae-familien, omfatter over 1500 arter, hvoraf mere end 160 er udbredt i Kina. Senecio scandens er en fler\u00e5rig plante af Senecio-sl\u00e6gten. Dens st\u00e6ngler er ofte snoede og klatrende med flere grene i den \u00f8verste del. Den har en hovedformet blomsterstand, gule blomster og blade, der er \u00e6gformede, trekantede eller elliptiske, lancetformede. Den er hovedsageligt udbredt i det \u00f8stlige, centrale, sydlige og sydvestlige Kina og findes for det meste i kuperede og bjergrige skove, buske, gr\u00e6sarealer og vejkanter. Qianli Guang er en traditionel kinesisk l\u00e6geurt, der virker varmeafledende og afgiftende, forbedrer synet og lindrer fugt. Den har ogs\u00e5 gode antiinflammatoriske, antibakterielle og antivirale virkninger.
\nForm\u00e5let med denne unders\u00f8gelse er at screene for anti-TMV-aktivitet i Qianli Guang og unders\u00f8ge de kemiske komponenter med anti-tobaksmosaikvirusaktivitet. Udv\u00e6lgelsen af de mest aktive forbindelser giver et teoretisk grundlag for forebyggelse og bek\u00e6mpelse af tobaksmosaiksygdom samt et videnskabeligt grundlag for ressourceudnyttelse af Senecio-planter.<\/p>\n

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\nPlanteriget producerer over 400.000 sekund\u00e6re metabolitter, herunder aktive ingredienser, der kan modst\u00e5 plantevirus, og de kemiske forsvarsstoffer, der produceres af planterne selv, har lav selvtoksicitet og er milj\u00f8venlige. Derfor er det en meget farbar vej at s\u00f8ge efter aktive stoffer mod TMV fra planter, og der har v\u00e6ret mange rapporter i de senere \u00e5r.
\nI denne unders\u00f8gelse blev der anvendt moderne og effektive fytokemiske separationsmetoder til at isolere 13 monomere forbindelser fra ethylacetatekstraktet af Senecio asiatica. Bortset fra forbindelserne 7 og 10 blev alle andre forbindelser isoleret fra Senecio asiatica for f\u00f8rste gang. Resultaterne af aktivitetstesten mod tobaksmosaikvirus viste, at forbindelse 8 havde en signifikant h\u00f8jere h\u00e6mmende hastighed p\u00e5 den beskyttende effekt af TMV-inficerede tobaksblade end Ningnanmycin; Forbindelserne 1, 4, 9-13 viste ingen signifikant forskel i beskyttende virkninger mod Xinye-tobak sammenlignet med Ningnan mycin, hvilket indikerer, at disse forbindelser kan f\u00e5 tobak til at erhverve plantesystemisk resistens mod vira. Den h\u00e6mmende hastighed af forbindelse 13 p\u00e5 den terapeutiske virkning af tobaksinfektion TMV er h\u00f8jere end Ningnanmycin; Inhiberingshastigheden for forbindelse 9 viste ingen signifikant forskel i forhold til Ningnanmycin. Der var ingen signifikant forskel i in vitro-inaktiveringseffekten af forbindelser 8 og 9 p\u00e5 TMV sammenlignet med inhiberingshastigheden for Ningnanmycin, hvilket indikerer, at disse to forbindelser direkte kan virke p\u00e5 virussen for at ud\u00f8ve anti-TMV-effekter.
\nSammenfattende har de kemiske komponenter i Senecio grandiflorus en betydelig h\u00e6mmende effekt p\u00e5 TMV, hvor alkaloider, terpener og nogle flavonoider viser st\u00e6rk anti-TMV-aktivitet. Det er v\u00e6rd at unders\u00f8ge n\u00e6rmere, om disse komponenter er de vigtigste antivirale aktive ingredienser. Denne unders\u00f8gelse beriger omfanget af Senecio grandiflorus' kemiske komponenter og biologiske aktiviteter og giver et videnskabeligt grundlag for gr\u00f8n forebyggelse og kontrol af tobaksmosaiksygdom i fremtiden.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Chemical Composition and Anti Tobacco Mosaic Virus Activity of Qianli Guang Plant viral diseases, also known as “plant cancers,” are the second largest plant diseases after fungal diseases. Due to the lack of ideal prevention and control measures, they cause huge losses to agricultural production, with economic losses caused by plant viruses […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Chemical Composition and Anti Tobacco Mosaic Virus Activity of Qianli Guang - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/tobacco-mosaic-virus\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Chemical Composition and Anti Tobacco Mosaic Virus Activity of Qianli Guang - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Chemical Composition and Anti Tobacco Mosaic Virus Activity of Qianli Guang Plant viral diseases, also known as “plant cancers,” are the second largest plant diseases after fungal diseases. 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