{"id":5474,"date":"2024-08-04T19:20:51","date_gmt":"2024-08-04T19:20:51","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5474"},"modified":"2024-08-04T19:20:51","modified_gmt":"2024-08-04T19:20:51","slug":"solanum-nigrum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/solanum-nigrum\/","title":{"rendered":"Udforsk mekanismen for Solanum nigrum i behandlingen af brystkr\u00e6ft baseret p\u00e5 netv\u00e6rksfarmakologi, molekyl\u00e6r docking-teknologi og in vitro-eksperimentel verifikation."},"content":{"rendered":"
Udforsk mekanismen for Solanum nigrum i behandlingen af brystkr\u00e6ft baseret p\u00e5 netv\u00e6rksfarmakologi, molekyl\u00e6r docking-teknologi og in vitro-eksperimentel verifikation.
\nBrystkr\u00e6ft er en af de mest almindelige ondartede tumorer blandt kvinder i verden, og det er ogs\u00e5 hoved\u00e5rsagen til kr\u00e6ftrelaterede d\u00f8dsfald blandt kvinder. Risikoen for brystkr\u00e6ft er relateret til mange faktorer, f.eks. alder, genetik, reproduktive faktorer og fedme. P\u00e5 nuv\u00e6rende tidspunkt er hormonbehandling, kirurgi, kemoterapi og str\u00e5lebehandling de vigtigste strategier til behandling af brystkr\u00e6ft. Men fordi brystkr\u00e6ft er en kompleks og meget heterogen sygdom, begr\u00e6nser multiresistens og alvorlige bivirkninger den terapeutiske effekt af disse behandlingsmetoder. Derfor er der et presserende behov for at udvikle mere effektive og sikre l\u00e6gemidler mod brystkr\u00e6ft. I kr\u00e6ftbehandling har traditionel kinesisk medicin og naturprodukter fordelene ved multi-level, multi pathway, multi-target, h\u00f8j effektivitet og minimale bivirkninger, hvilket viser gode antitumoreffekter. Mens traditionel kinesisk medicin og dens aktive forbindelser er kendetegnet ved en klar helbredende effekt, sm\u00e5 toksiske virkninger og bivirkninger, rige m\u00e5l og forskellige mekanismer mod brystkr\u00e6ft. Medicin mod brystkr\u00e6ft fra traditionel kinesisk medicin har gode udsigter til udvikling og anvendelse.
\nSolanum nigrum L. er en l\u00e6geplante i Solanaceae-familien, der er vidt udbredt i Europa, Asien og Nord- og Sydamerika. Longkui har anti-cancer, anti-inflammatoriske, antioxidante, antibakterielle og antiepileptiske virkninger. De vigtigste bioaktive komponenter omfatter steroide saponiner, alkaloider, fenoler og polysaccharider. Moderne forskning viser, at Solanum nigrum og dets aktive ingredienser (prim\u00e6rt steroider, organiske syrer, lignaner og andre) kan bruges til at behandle forskellige typer kr\u00e6ft, f.eks. leverkr\u00e6ft, livmoderhalskr\u00e6ft, kr\u00e6ft i bugspytkirtlen, brystkr\u00e6ft osv. Solanum nigrum-methanolekstrakt kan inducere autofagi og apoptose af brystkr\u00e6ftcellelinjen MDA-MB-468. Solanum nigrum-vandekstrakt og ethanolekstrakt har cytotoksicitet over for brystkr\u00e6ftcellelinjen MCF-7 og inducerer apoptose og cyklusstop af MCF-7-cellelinjen. Derudover kan Solanum nigrum ogs\u00e5 spille en rolle mod brystkr\u00e6ft gennem epigenetisk modulering. Diosgenin er en slags naturligt steroidsaponin fra Dioscorea-planter, som har god antitumoraktivitet. Forskning viser, at diosgenin kan h\u00e6mme migrationen af MDA-MB-231 brystkr\u00e6ftceller ved at h\u00e6mme Vav2-aktiviteten og p\u00e5virke cellernes migrationsadf\u00e6rd, hvilket afsl\u00f8rer, at diosgenin kan have et antimetastasepotentiale. Selvom ovenst\u00e5ende forskning har gjort nogle fremskridt, er det materielle grundlag, handlingsm\u00e5l og detaljerede molekyl\u00e6re mekanismer for Solanum nigrum mod brystkr\u00e6ft ikke helt klare. Baseret p\u00e5 de tekniske metoder til netv\u00e6rksfarmakologi og molekyl\u00e6r docking konstruerede denne unders\u00f8gelse et netv\u00e6rksforhold p\u00e5 flere niveauer og med flere vinkler \"l\u00e6gemiddelm\u00e5lvejssygdom\" og verificerede det ved at kombinere in vitro-celleeksperimenter. Det var klart, at den effektive komponent i Solanum nigrum kunne h\u00e6mme spredningen af MDA-MB-231-celler i brystkr\u00e6ft og inducere celleapoptose og forel\u00f8bigt udforskede den molekyl\u00e6re virkningsmekanisme for diosgenin, hvilket gav en reference til yderligere forskning i Solanum nigrum til behandling af brystkr\u00e6ft.<\/p>\n

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\nSolanum nigrum er en traditionel kinesisk urtemedicin. Moderne farmakologi har fundet ud af, at Solanum nigrum har forskellige biologiske aktiviteter, hvoraf de fleste er koncentreret inden for antitumor. Unders\u00f8gelser har vist, at dets aktive ingrediens, diosgenin, kan ud\u00f8ve antitumoreffekter ved at regulere forskellige cellul\u00e6re signalveje og er t\u00e6t forbundet med mange vigtige molekyl\u00e6re m\u00e5l som cellev\u00e6kst, differentiering og apoptose.
\nGennem analyse af TCMSP-databasen for netv\u00e6rksfarmakologi screenede denne unders\u00f8gelse syv effektive aktive ingredienser, nemlig fraxinol, \u03b2-caroten, sitosterol, diosgenin, solanin, kolesterol og quercetin. Krydset blev opn\u00e5et ved at kortl\u00e6gge de relevante m\u00e5l for de aktive ingredienser i Solanum nigrum med introduktionslinjesoftwaren VENNY 2.1 for brystkr\u00e6ftsygdomme. Samtidig viste PPI-netv\u00e6rksanalysen, at der var et t\u00e6t forhold mellem disse krydsningsm\u00e5l. Unders\u00f8gelser har vist, at quercetin, australsk solanin og sitosterol har farmakologiske virkninger, s\u00e5som at h\u00e6mme tumorcelleproliferation og inducere tumorcelleapoptose. Diosgenin kan fremme apoptose af brystkr\u00e6ft MCF-7-celler og Skp2-celler. Ud fra dette kan man se, at de aktive ingredienser i Solanum nigrum, s\u00e5som quercetin, solanin, sitosterol og dioscin, kan ud\u00f8ve antitumoreffekter.
\nIf\u00f8lge netv\u00e6rksdiagrammet for sammensatte m\u00e5l blev der opn\u00e5et 110 m\u00e5l efter sk\u00e6ringspunktet mellem Solanum nigrum og sygdomsm\u00e5l. Yderligere screening viste, at ERBB2, EGFR, KIT, SRC, ESR1, AKT1, MAPK1, PIK3CA osv. var m\u00e5lproteinerne for de effektive ingredienser i Solanum nigrum til behandling af brystkr\u00e6ft. Blandt dem virker resveratrol, diosgenin og quercetin alle p\u00e5 AKT1- og EGFR-m\u00e5l, og AKT (serin\/threoninkinase) og EGFR (epidermal v\u00e6kstfaktorreceptor) spiller vigtige roller i celleproliferation, migration og metabolisme. Derfor er m\u00e5lretning mod AKT og EGFR en meget attraktiv behandlingsstrategi for brystkr\u00e6ft. Resultaterne af denne unders\u00f8gelse indikerer, at AKT1 og EGFR og andre m\u00e5l spiller en vigtig rolle i udviklingen af brystkr\u00e6ft og kan v\u00e6re potentielle m\u00e5l for Solanum nigrum i behandlingen af brystkr\u00e6ft. GO-berigelsesanalyse viser, at m\u00e5lgenerne for Solanum nigrum mod brystkr\u00e6ft involverer biologiske processer s\u00e5som positiv regulering af kinaseaktivitet, bindende protein serin \/ threonin kinaseaktivitet, positiv regulering af MAPK-kaskade, positiv regulering af PI3K-signal, ATP-binding osv. Disse n\u00f8gleprocesser spiller en vigtig rolle i Solanum nigrums behandling af brystkr\u00e6ft. KEGG-resultaterne viste, at i alt 137 signalveje blev beriget, herunder kr\u00e6ftvej, PI3K\/Akt-signalvej, EGFR-tyrosinkinaseinhibitorresistens-signalvej, ErbB-signalvej, MAPK-signalvej, Ras-signalvej, Rap1-signalvej osv.
\nMolekyl\u00e6r docking-teknologi blev brugt til at unders\u00f8ge affiniteten mellem de vigtigste aktive komponenter og m\u00e5lproteinerne i Solanum nigrum. Resultaterne viste, at de aktive komponenter som quercetin, sitosterol og diosgenin havde god bindingsaktivitet med m\u00e5let AKT1, EGFR, ESR1, SRC og MAPK, hvilket afspejler, at hovedmekanismen for de vigtigste aktive komponenter i Solanum nigrum, sitosterol og quercetin i behandlingen af brystkr\u00e6ft kan v\u00e6re t\u00e6t forbundet med de ovenn\u00e6vnte aktive komponenter og m\u00e5l. Solanum nigrum kan have en vis terapeutisk effekt p\u00e5 brystkr\u00e6ft gennem flere m\u00e5l og flere signalveje.
\nBaseret p\u00e5 resultaterne af molekyl\u00e6r dockingforskning blev den vigtigste aktive ingrediens i Solanum nigrum, Diosgenin, udvalgt til antitumoreksperimenter, og Diosgenins regulerende effekt p\u00e5 de forudsagte m\u00e5l EGFR og AKT1 blev verificeret. At udforske den potentielle mekanisme for diosgenin mod brystkr\u00e6ft. De eksperimentelle resultater viste, at dioscin kan h\u00e6mme spredningen af MDA-MB-231-celler og fremkalde apoptose af MDA-MB-231-celler. Dioscin kan nedregulere ekspressionen af EGFR-protein og opregulere ekspressionen af AKT1-protein i celler. Det er v\u00e6rd at bem\u00e6rke, at dioscin kan nedregulere fosforyleringsniveauet af AKT, og samtidig kan det opregulere ekspressionen af pro-apoptotisk protein Bax og nedregulere ekspressionen af antiapoptotisk protein Bcl-2.
\nFor at opsummere anvendte denne unders\u00f8gelse netv\u00e6rksfarmakologidataplatformen til at analysere og screene de vigtigste aktive ingredienser i Solanum nigrum og analyserede multikomponent-, multim\u00e5l- og multivejsmekanismen for Solanum nigrum til behandling af brystkr\u00e6ft og udf\u00f8rte eksperimentel verifikation in vitro. Resultaterne viste, at Solanum nigrum kan virke p\u00e5 AKT1, EGFR og andre m\u00e5l for at spille en rolle i behandlingen af brystkr\u00e6ft, hvilket giver ideer og grundlag for yderligere dybtg\u00e5ende forskning i den relaterede mekanisme for Solanum nigrum til behandling af brystkr\u00e6ft og efterf\u00f8lgende klinisk anvendelsesforskning af Solanum nigrum.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

Explore the mechanism of Solanum nigrum in the treatment of breast cancer based on network pharmacology, molecular docking technology and in vitro experimental verification Breast cancer is one of the most common malignant tumors among women in the world, and it is also the main cause of cancer related deaths among women. 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