{"id":5438,"date":"2024-08-04T19:01:41","date_gmt":"2024-08-04T19:01:41","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5438"},"modified":"2024-08-04T19:01:41","modified_gmt":"2024-08-04T19:01:41","slug":"ad","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/ad\/","title":{"rendered":"Fremskridt i forskningen i naturlige aktive ingredienser mod Alzheimers sygdom baseret p\u00e5 m\u00e5lmekanismer"},"content":{"rendered":"

Fremskridt i forskningen i naturlige aktive ingredienser mod Alzheimers sygdom baseret p\u00e5 m\u00e5lmekanismer
\nAlzheimers sygdom (AD) er en degenerativ neurologisk lidelse, som er mere almindelig i den \u00e6ldre befolkning p\u00e5 65 \u00e5r og derover. Tidlige kliniske manifestationer af Alzheimers sygdom omfatter sv\u00e6kket korttidshukommelse, som gradvist forv\u00e6rres og ledsages af flere funktionelle sv\u00e6kkelser som sprog, kognition, orientering og d\u00f8mmekraft, hvilket i alvorlig grad p\u00e5virker patienternes daglige evner og endda bringer deres liv i fare. If\u00f8lge World AD Report 2021 udgivet af International AD Association er der ca. 55 millioner demenspatienter p\u00e5 verdensplan, og det ansl\u00e5s, at der er 10 millioner nye tilf\u00e6lde om \u00e5ret. Demens for\u00e5rsaget af Alzheimers sygdom udg\u00f8r ca. 64% af demenstilf\u00e6ldene. Der er n\u00e6sten 10 millioner AD-patienter i Kina, hvilket g\u00f8r det til det land med det h\u00f8jeste antal patienter i verden, og det forventes at overstige 40 millioner i 2050. Med den accelererende aldring af den globale befolkning er Alzheimers sygdom ikke kun blevet et vigtigt folkesundhedssp\u00f8rgsm\u00e5l, men ogs\u00e5 et alvorligt socialt problem.
\nAD debuterer snigende, og sygdomsforl\u00f8bet er irreversibelt. I \u00f8jeblikket kan de l\u00e6gemidler mod Alzheimers sygdom, der anvendes i klinisk praksis, kun forsinke sygdomsudviklingen, de kan ikke vende tilstanden og har en vis grad af bivirkninger. Udviklingen af h\u00f8jeffektive anti-AD-l\u00e6gemidler med lav toksicitet er fortsat en alvorlig udfordring for den globale medicinalindustri. De patologiske tr\u00e6k ved AD omfatter hovedsageligt ekstracellul\u00e6re senile plaques med \u03b2-amyloid (A \u03b2) som kerne, der dannes i hjernebarken og hippocampus, neurofibrill\u00e6re tangles (NFT'er) med abnorm fosforylering af tau-protein som kerne og neuronalt tab. Men den dag i dag er patogenesen af AD ikke fuldt ud forst\u00e5et. Baseret p\u00e5 de patologiske egenskaber ved AD inkluderer det hovedsageligt forskellige teorier s\u00e5som A \u03b2-teori, tau-proteinteori, teori om kolinerg skade, teori om immuninflammation og tarmmikrobiota, hvilket indikerer, at patogenesen af AD er kompleks, og at forekomsten og udviklingen involverer flere mekanismer. L\u00e6gemiddeludviklingsstrategien baseret p\u00e5 forskellige mekanismem\u00e5l er blevet den vigtigste forskningsretning for nuv\u00e6rende anti-AD-l\u00e6gemidler.
\nNaturprodukter indeholder et stort udvalg af aktive ingredienser med egenskaber og fordele ved multikomponent- og multim\u00e5l-effekter, som er i overensstemmelse med patogenesen af neurodegenerative sygdomme med flere faktorer og patologiske mekanismer ved AD. Med den kontinuerlige optimering af moderne separations- og identifikationsteknologi er screening og opdagelse af effektive, meget selektive og m\u00e5lrettede anti-AD-aktive ingredienser med lav toksicitet fra naturlige produkter en af de vigtige tilgange til udvikling af anti-AD-medicin. Denne artikel er baseret p\u00e5 de nuv\u00e6rende enkeltm\u00e5ls- og multim\u00e5lsscreeningsstrategier for udvikling af AD-l\u00e6gemidler kombineret med forskellige m\u00e5l, der er involveret i patogenesen af AD, for at gennemg\u00e5 og opsummere de anti-AD-aktive ingredienser, der er opdaget i naturlige produkter i de senere \u00e5r, for at give reference til udviklingen af effektive anti-AD-l\u00e6gemidler.<\/p>\n

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\nNaturprodukter har forskellige typer og brede farmakologiske aktiviteter og har altid v\u00e6ret en vigtig kilde til udvikling af nye l\u00e6gemidler. Den h\u00f8je fejlrate i de nuv\u00e6rende kliniske fors\u00f8g med AD-l\u00e6gemiddelkandidater tjener som en advarsel om, at vi er n\u00f8dt til at st\u00e5 over for vanskeligheder og udfordringer i forbindelse med screening af potentielle aktive ingredienser til anti-AD-l\u00e6gemidler. N\u00e5r man analyserer den nuv\u00e6rende situation, er der stadig nogle problemer med screening og klinisk anvendelse af naturlige anti-AD-aktive ingredienser. For det f\u00f8rste er traditionelle high-throughput-screeningsmetoder ikke l\u00e6ngere tilstr\u00e6kkelige til at opfylde behovene for udvikling af nye l\u00e6gemidler med den eksponentielle stigning i antallet af opdagede aktive ingredienser. I de senere \u00e5r har nye virtuelle screeningsteknologier baseret p\u00e5 kunstig intelligens som f.eks. molekyl\u00e6re lighedsmetoder, maskinl\u00e6ring og dyb l\u00e6ring givet nye muligheder for at opdage hovedforbindelser i naturprodukter p\u00e5 grund af deres betydelige fordele i form af h\u00f8j effektivitet og lave omkostninger. Derfor vil kombinationen af virtuel screeningsteknologi og eksperimentel verifikation fremskynde opdagelsescyklussen for naturprodukter som nye kemiske rammer eller aktive forstadier til anti-AD-medicin. For det andet kan de nuv\u00e6rende AD-dyremodeller ikke fuldt ud simulere alle de patologiske tr\u00e6k ved AD. Vi er n\u00f8dt til bedre at forst\u00e5 de enkelte modellers egenskaber og begr\u00e6nsninger, bruge flere modeller til at evaluere den terapeutiske effekt af naturprodukter p\u00e5 AD og afklare deres m\u00e5l og molekyl\u00e6re virkningsmekanismer. Igen har nogle naturlige anti-AD-aktive ingredienser problemer s\u00e5som lav biotilg\u00e6ngelighed og vanskeligheder med at krydse blod-hjerne-barrieren. Der er behov for yderligere strukturel modifikation og optimering, eller der b\u00f8r anvendes modifikationer af doseringsformen og metoder til kombinationsbehandling for at forbedre m\u00e5lselektiviteten og anti-AD-effekten. Ud over plantebaserede naturprodukter udg\u00f8r naturprodukter fra hav- og svampekilder ogs\u00e5 nye kilder til udvikling af l\u00e6gemidler mod AD.<\/p>\n

Jeg tror, at der med den fortsatte udforskning af AD's patogenese p\u00e5 det medicinske omr\u00e5de, den fortsatte udvikling og fremgang af moderne analytiske teknikker, m\u00e5lrettede screeningsmetoder, computerst\u00f8ttet l\u00e6gemiddeldesign og kunstig intelligens-teknologi vil blive gjort betydelige fremskridt i udviklingen af anti-AD-l\u00e6gemidler fra naturlige produkter.<\/p>","protected":false},"excerpt":{"rendered":"

Research progress on natural active ingredients for anti Alzheimer’s disease based on target mechanism Alzheimer’s disease (AD) is a degenerative neurological disorder that is more common in the elderly population aged 65 and above. Early clinical manifestations of AD include short-term memory impairment, which gradually worsens and is accompanied by multiple functional impairments such as […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nResearch progress on natural active ingredients for anti Alzheimer's disease based on target mechanism - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/ad\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress on natural active ingredients for anti Alzheimer's disease based on target mechanism - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research progress on natural active ingredients for anti Alzheimer’s disease based on target mechanism Alzheimer’s disease (AD) is a degenerative neurological disorder that is more common in the elderly population aged 65 and above. 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