{"id":5066,"date":"2024-08-04T17:08:27","date_gmt":"2024-08-04T17:08:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5066"},"modified":"2024-08-04T17:08:27","modified_gmt":"2024-08-04T17:08:27","slug":"a-new-amide-alkaloid-in-the-root-of-fake-konjac","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/a-new-amide-alkaloid-in-the-root-of-fake-konjac\/","title":{"rendered":"Et nyt amidalkaloid i roden af falsk konjak"},"content":{"rendered":"

Et nyt amidalkaloid i roden af falsk konjak
\nPiper sarmentosum er en fler\u00e5rig, krybende urt med r\u00f8dder fra knude til knude i Piperaceae-familien, som ofte findes i underskoven eller i v\u00e5domr\u00e5der langs vejene. Den produceres hovedsageligt i provinser som Yunnan, Fujian og Guizhou i Kina og er ogs\u00e5 udbredt i Indien, Vietnam, Filippinerne og Malaysia. Falsk konjak har ikke kun stor medicinsk v\u00e6rdi, men ogs\u00e5 h\u00f8j dekorativ, spiselig og \u00f8konomisk v\u00e6rdi. If\u00f8lge klassikere som \"Chinese Materia Medica\" har falsk konjac en varm natur og en bitter og skarp smag. Dens r\u00f8dder, blade og frugter kan alle bruges som medicin med den virkning, at de opvarmer midten og spreder kulde, fordriver vind og fugt og reducerer h\u00e6velser og smerter. Det bruges ofte til behandling af mavesmerter, reumatiske rygsmerter, graviditets\u00f8dem og traumatiske bl\u00f8dninger med betydelige terapeutiske virkninger. Falske konjakblade bruges og dyrkes i vid udstr\u00e6kning som krydderi i det sydlige Kinas Jiangsu-, Zhejiang- og Guangdong-regioner p\u00e5 grund af deres unikke skarpe aroma.
\nModerne farmakologiske unders\u00f8gelser har vist, at ekstrakter af falsk konjac har en bred vifte af biologiske aktiviteter, s\u00e5som antioxidante, antiinflammatoriske, antibakterielle, insektdr\u00e6bende, hypoglyk\u00e6miske og neurobeskyttende egenskaber. P\u00e5 nuv\u00e6rende tidspunkt er forskningen i den kemiske sammens\u00e6tning af falsk konjac b\u00e5de nationalt og internationalt hovedsageligt fokuseret p\u00e5 bladene og de overjordiske dele, mens der er forsket relativt lidt i de underjordiske r\u00f8dder. De kemiske komponenter, der er isoleret og identificeret fra falsk konjac, omfatter alkaloider, lignaner, flavonoider og steroler. Vores forskningsgruppe isolerede 7 alkaloidforbindelser fra falske konjakblade i den tidlige fase, hvoraf nogle viste god antibakteriel aktivitet mod Staphylococcus aureus. I den l\u00f8bende forskning i den kemiske sammens\u00e6tning og biologiske aktivitet af falsk konjac blev det konstateret, at 95%-ethanolekstraktet af falsk konjacrod kan lindre symptomerne p\u00e5 h\u00e6velse af musef\u00f8dder fremkaldt af carrageenan og har en dosisafh\u00e6ngig effekt. Derfor spekuleres der i, at ekstraktet indeholder antiinflammatoriske aktive ingredienser. Relaterede unders\u00f8gelser har vist, at alkaloider er de vigtigste aktive ingredienser i roden af falsk konjak. Dette eksperiment unders\u00f8gte den kemiske sammens\u00e6tning af 95%-ethanolekstraktet af falsk konjakrod og brugte den LPS-inducerede RAW264.7 in vitro-celleinflammationsmodel til at screene den antiinflammatoriske aktivitet af de opn\u00e5ede monomere forbindelser. Form\u00e5let er at klarl\u00e6gge den kemiske sammens\u00e6tning og det relaterede farmakologiske stofgrundlag af falsk konjakrod for at give reference til yderligere rationel udvikling og udnyttelse af falske konjakplanteressourcer.<\/p>\n

\"\"\"\"\"\"
\nI dette eksperiment blev der brugt moderne kromatografiske separationsteknikker og spektroskopiske metoder til at isolere og identificere 10 alkaloidforbindelser fra roden af falsk konjak. Blandt dem er forbindelse 1 et nyt amidalkaloid, og alle forbindelser undtagen forbindelse 5 er isoleret fra denne plante for f\u00f8rste gang. Den anti-inflammatoriske aktivitet af de isolerede forbindelser blev evalueret ved hj\u00e6lp af en LPS-stimuleret RAW264.7-makrofag-bet\u00e6ndelsesmodel. Resultaterne viste, at forbindelserne 1, 2, 4 og 10 havde en h\u00e6mmende effekt p\u00e5 NO-produktionen og ikke udviste signifikant cytotoksicitet ved de testede koncentrationer. Resultaterne af denne unders\u00f8gelse beriger yderligere den kemiske sammens\u00e6tning af falsk konjakrod og afklarer forel\u00f8bigt grundlaget for nogle antiinflammatoriske aktive stoffer i falsk konjakrod, hvilket giver visse referencer og teoretisk grundlag for den fremtidige udvikling og udnyttelse af denne planteressource.<\/p>","protected":false},"excerpt":{"rendered":"

A new amide alkaloid in the root of fake konjac Piper sarmentosum is a perennial, creeping, node by node rooted herb of the Piperaceae family, commonly found in understory or roadside wetlands. It is mainly produced in provinces such as Yunnan, Fujian, and Guizhou in China, and is also distributed in India, Vietnam, the Philippines, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nA new amide alkaloid in the root of fake konjac - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/a-new-amide-alkaloid-in-the-root-of-fake-konjac\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new amide alkaloid in the root of fake konjac - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"A new amide alkaloid in the root of fake konjac Piper sarmentosum is a perennial, creeping, node by node rooted herb of the Piperaceae family, commonly found in understory or roadside wetlands. 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