{"id":4840,"date":"2024-08-04T16:03:22","date_gmt":"2024-08-04T16:03:22","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4840"},"modified":"2024-08-04T16:03:22","modified_gmt":"2024-08-04T16:03:22","slug":"allergic-rhinitis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/allergic-rhinitis\/","title":{"rendered":"Udforskning af medicinregler og relateret farmakologisk analyse af traditionel kinesisk medicin til behandling af allergisk rhinitis baseret p\u00e5 datamining, netv\u00e6rksfarmakologi og eksperimentel verifikation."},"content":{"rendered":"<p>Udforskning af medicinregler og relateret farmakologisk analyse af traditionel kinesisk medicin til behandling af allergisk rhinitis baseret p\u00e5 datamining, netv\u00e6rksfarmakologi og eksperimentel verifikation.<br \/>\nAllergisk rhinitis (AR), ogs\u00e5 kendt som allergisk rhinitis, er en kronisk, ikke-infekti\u00f8s bet\u00e6ndelse i n\u00e6seslimhinden for\u00e5rsaget af frigivelse af inflammatoriske faktorer (histamin, leukotriener, prostaglandiner, blodpladeaktiverende faktorer osv.) medieret af immunoglobulin E (IgE) efter eksponering for allergener hos atopiske personer, og som involverer flere immunaktive celler og immunfaktorer. Inflammatoriske faktorer for\u00e5rsager \u00f8dem og ekssudation af den lokale n\u00e6seslimhinde og stimulerer n\u00e6sens sensoriske nerver, hvilket resulterer i typiske symptomer som paroxysmal og tilbagevendende nasal kl\u00f8e, nys og vandigt n\u00e6sefl\u00e5d. Det kan ogs\u00e5 ledsages af tilstoppet n\u00e6se, nedsat lugtesans, astma og andre symptomer. AR er t\u00e6t forbundet med genetiske faktorer, regionalt klima, luftforurening, neurologiske og psykologiske faktorer samt socio\u00f8konomiske faktorer ud over allergener. AR h\u00f8rer til kategorien \"tilstoppet n\u00e6se\" i traditionel kinesisk medicin. Traditionel kinesisk medicin mener, at denne sygdom er resultatet af den kombinerede virkning af interne og eksterne faktorer. De indre faktorer er for det meste organmangel og utilstr\u00e6kkelig positiv qi, mens de ydre faktorer for det meste er vind, kulde eller fremmed qi-invasion med sammenst\u00f8d mellem ond og positiv qi og manglende evne til at frig\u00f8re lunge-qi, hvilket resulterer i tilstoppet n\u00e6se. I klinisk praksis bruges antihistaminer og nasale kortikosteroider hovedsageligt til at behandle AR, men langvarig brug har d\u00e5rlig effekt og er tilb\u00f8jelig til at vende tilbage. Traditionel kinesisk medicin behandler AR gennem oral administration, n\u00e6seskylning af kinesiske urteafkog eller anvendelse af akupunkturpunkter, kinesisk urtefumigation, forst\u00f8vning og andre metoder. Denne artikel bruger datamining-metoder til at analysere medicineringsm\u00f8nstrene for traditionel kinesisk medicin i behandlingen af AR og bruger netv\u00e6rksfarmakologi og in vivo-farmakologiverificeringsmetoder til at forudsige og verificere den potentielle virkningsmekanisme for h\u00f8jfrekvent traditionel kinesisk medicin i behandlingen af AR, hvilket giver rationel reference og videnskabeligt teoretisk grundlag for dens kliniske behandling af AR.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4846\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-6.jpg\" alt=\"\" width=\"802\" height=\"192\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-6.jpg 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-6-768x184.jpg 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4847\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-86.png\" alt=\"\" width=\"802\" height=\"282\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-86.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-86-768x270.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4848\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-83.png\" alt=\"\" width=\"802\" height=\"256\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-83.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-83-768x245.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4849\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-71.png\" alt=\"\" width=\"802\" height=\"267\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-71.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-71-768x256.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4850\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-67.png\" alt=\"\" width=\"802\" height=\"346\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-67.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-67-768x331.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4851\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-59.png\" alt=\"\" width=\"802\" height=\"395\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-59.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-59-768x378.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4852\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-55.png\" alt=\"\" width=\"802\" height=\"335\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-55.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-55-768x321.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4853\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-48.png\" alt=\"\" width=\"801\" height=\"515\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-48.png 801w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-48-768x494.png 768w\" sizes=\"(max-width: 801px) 100vw, 801px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4854\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-43.png\" alt=\"\" width=\"802\" height=\"400\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-43.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-43-768x383.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4855\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-37.png\" alt=\"\" width=\"612\" height=\"304\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4856\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-31.png\" alt=\"\" width=\"612\" height=\"701\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4857\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-27.png\" alt=\"\" width=\"802\" height=\"506\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-27.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-27-768x485.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4858\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-22.png\" alt=\"\" width=\"602\" height=\"715\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4859\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-19.png\" alt=\"\" width=\"802\" height=\"517\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-19.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-19-768x495.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4860\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-14.png\" alt=\"\" width=\"802\" height=\"380\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-14.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-14-768x364.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4861\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-12.png\" alt=\"\" width=\"802\" height=\"699\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-12.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-12-768x669.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4862\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-11.png\" alt=\"\" width=\"802\" height=\"266\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-11.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-11-768x255.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4863\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-9.png\" alt=\"\" width=\"575\" height=\"264\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4865\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-7.png\" alt=\"\" width=\"802\" height=\"580\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-7.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-7-768x555.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4867\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-6.png\" alt=\"\" width=\"802\" height=\"311\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-6.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-6-768x298.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4868\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-4.png\" alt=\"\" width=\"802\" height=\"319\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-4.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-4-768x305.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4869\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/22-3.png\" alt=\"\" width=\"509\" height=\"214\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4870\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/23-2.png\" alt=\"\" width=\"579\" height=\"230\" \/>I frekvensanalysen af traditionel kinesisk medicin til behandling af AR er de fem hyppigst anvendte urter Xinyi, Huangqi, Fangfeng, lakrids og Cang'er Zi. Xinyi, som er den hyppigst anvendte traditionelle kinesiske medicin, har en varm natur, kan fjerne vind og kulde og fremme nasal \u00e5bning. Hovedkomponenterne er flygtige olier, lignaner og alkaloider, som har en lang r\u00e6kke farmakologiske virkninger, s\u00e5som beskyttelse af slimhinder, forbedring af den lokale blodcirkulation, antiinflammatoriske, antibakterielle, antiallergiske, antioxidante og afslappende glatte muskler. Xinyi bruges ofte som kongelig medicin til behandling af forskellige former for rhinitis og n\u00e6sesygdomme, f.eks. Xinyi Rhinitis Pills, Biyan Kang Tablets, Biyuan Pills, Tongqiao Rhinitis Granules, Xinfang Rhinitis Capsules, Xinyi Powder, Xinyi Pills, Xinyi Ointment, Sinus Infusion Fluid osv. Li Shizhen skrev ogs\u00e5 i Compendium of Materia Medica, at \"Xinyi kan varme midten og behandle sygdomme i hovedet, ansigtet, n\u00e6sen og de ni krops\u00e5bninger\".<br \/>\nGennem forskning har det vist sig, at blandt 252 traditionelle kinesiske medicinrecepter er l\u00e6gemiddelklassifikationen hovedsageligt baseret p\u00e5 overfladeklarende l\u00e6gemidler (s\u00e5som Xinyi, Fangfeng, Xixin, Baizhi, Guizhi osv.) og mangeltonificerende l\u00e6gemidler (s\u00e5som Huangqi, lakrids, Atractylodes macrocephala osv.). De medicinske egenskaber er for det meste fokuseret p\u00e5 opvarmning, og de medicinske smage er hovedsageligt krydrede og s\u00f8de. Varme urter har den virkning, at de opvarmer midten og fordriver kulde, tonificerer ild og hj\u00e6lper yang. Krydrede urter kan fjerne vind og kulde, fremme qi og blodcirkulation. S\u00f8de urter harmoniserer de medicinske egenskaber, giver n\u00e6ring til midten og regulerer meridianerne i lunger, milt og lever. Baseret p\u00e5 en omfattende analyse er den eneste traditionelle kinesiske medicin, der bruges til at behandle AR, for det meste Xinyi, Fangfeng, Cang'er Zi, Xixin, Baizhi, Guizhi osv., som hovedsageligt bruges til vind og kolde manifestationer som kulderystelser, feber, hovedpine, sved, \u00f8mhed i lemmerne, l\u00f8bende n\u00e6se, tilstoppet n\u00e6se, tynd og hvid pels, kl\u00f8e i halsen og hoste og flydende puls.<br \/>\nI analysen af associationsregler, er de centrale l\u00e6gemiddelkombinationer med h\u00f8j st\u00f8tte Huangqi Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylo. Bortset fra Schisandra chinensis, Cicada molt og pebermynte ligger de almindeligt anvendte doser af andre h\u00f8jfrekvente l\u00e6gemidler inden for det doseringsomr\u00e5de, der er angivet i den kinesiske farmakop\u00e9.<br \/>\nI klyngeanalysen fokuserer en gruppe traditionelle kinesiske l\u00e6gemidler hovedsageligt p\u00e5 at styrke manglen og lindre de ydre symptomer. Blandt dem kan den vigtigste aktive ingrediens i Astragalus membranaceus, Astragalus polysaccharider, lindre symptomer som nysen, kradsen i n\u00e6sen og l\u00f8bende n\u00e6se hos AR-rotter. Det kan reducere bet\u00e6ndelsen i AR-rotters n\u00e6seslimhindev\u00e6v ved at opregulere udtrykket af T-bet og IFN - \u03b3 mRNA, nedregulere udtrykket af GATA-3 og IL-4 mRNA og fremme genopretningen af AR ved at reducere niveauerne af inflammatoriske faktorer s\u00e5som serum IL-4, IL-6, IL1 \u03b2, IgE, TNF - \u03b1 osv. Vindt\u00e6t har den virkning, at det fjerner vind, lindrer overfladefugt og lindrer kl\u00f8e. Vindt\u00e6tte polysaccharider har vist sig at have gode antiallergiske virkninger gennem in vitro-eksperimenter. Vindt\u00e6tte alkoholekstrakter kan ud\u00f8ve antiallergiske virkninger ved at reducere udtrykket af PAR-2 i in vitro-celler. Guizhi virker svedtransporterende og muskelaflastende, opvarmer og fremmer meridianer, hj\u00e6lper yang med at omdanne qi og spreder eksterne vindpatogener. Ju Er Cang Er Zi virker ved at sprede vind og kulde, fremme n\u00e6se\u00e5bning og sprede vind og fugt. Det bruges til behandling af vind og kold hovedpine, tilstoppet n\u00e6se og l\u00f8bende n\u00e6se, tilstoppet n\u00e6se, nasale bihuler, gigt og kl\u00f8e samt fugtig stagnation og spasmer; n-butanolekstraktet af Fructus Xanthii kan lindre n\u00e6seslimhindebet\u00e6ndelse hos AR-marsvin, reducere antallet af hvide blodlegemer, eosinofilprocent og SIgE-niveauer i serum; Vandekstraktet af Atractylodes macrocephala kan lindre symptomer som l\u00f8srivelse af n\u00e6seslimhinden, v\u00e6vs\u00f8dem og inflammatorisk celleinfiltration hos AR-marsvin og reducere ekspressionsniveauerne af inflammatoriske cytokiner IgE, IL-4 og IFN - \u03b3 i serum.<br \/>\nDenne artikel s\u00f8gte i TCMSP-databasen og supplerede litteraturen og fandt i alt 48 aktive ingredienser i Huangqi Xinyi-medicinparret, svarende til 306 m\u00e5lpunkter. Hver ingrediens bruges til flere m\u00e5l. For yderligere at illustrere forholdet mellem m\u00e5lpunkter og komponenter blev der konstrueret et \"komponentm\u00e5lsygdom\"-netv\u00e6rk ved at tage sk\u00e6ringspunktet mellem komponentm\u00e5l og sygdomsm\u00e5l. Hovedkomponenterne, kaempferol og quercetin, viste sig at have den h\u00f8jeste korrelation med m\u00e5lene og kan v\u00e6re n\u00f8glekomponenterne i Huangqi Xinyi til behandling af AR, idet de spiller vigtige farmakologiske roller. Unders\u00f8gelser har vist, at kaempferol kan reducere forekomsten af tarmbet\u00e6ndelse ved at forbedre integriteten af tarmbarrieren og har betydelige antihyperglyk\u00e6miske og antioxidante virkninger; Quercetin kan reducere aterosklerotisk inflammation betydeligt ved at h\u00e6mme bindingen af galectin-3 og NLRP3. Yderligere analyse af KEGG-stien afsl\u00f8rede, at den neuroaktive ligandreceptorinteraktionsvej, calciumion-signalvej, steroidhormonbiosyntesevej og kr\u00e6ftvej er de vigtigste veje, hvorigennem Huangqi Xinyi ud\u00f8ver sine anti AR-effekter, der involverer 34 aktive ingredienser og 39 kernem\u00e5l. Ved at analysere forholdet mellem \"komponentm\u00e5lvejssygdom\" fandt vi ud af, at PTGS2, HSP90, NOS2, CALM1, CHRM1, CYP1B1 og andre m\u00e5lproteiner spiller en vigtig rolle i vejen. PTGS2 er involveret i patologiske reaktioner som inflammation eller tumorer og er et m\u00e5l for ikke-steroide antiinflammatoriske l\u00e6gemidler. Det kan i h\u00f8j grad induceres af pro-inflammatoriske cytokiner og v\u00e6kstfaktorer til at udskille inflammatoriske faktorer, hvilket udl\u00f8ser en inflammatorisk reaktion. HSP90 er en ATP-afh\u00e6ngig molekyl\u00e6r chaperon, der kan hj\u00e6lpe klientproteiner med at gennemf\u00f8re korrekt rumlig foldning og deltage i reguleringen af cellecyklus. Unders\u00f8gelser har vist, at HSP90 kan regulere lymfocytaktivering, fremme lymfocytmigration til infektionssteder og lette lokale inflammatoriske reaktioner under fysiologisk stress i kroppen. NOS2 er en inducerbar nitrogenoxidsyntase, der udtrykkes efter skader i kroppen, og som kan udnytte nitrogenoxids oxidative stress til at deltage i immunregulering og inflammatorisk respons i kroppen. CALM1 er et calmodulinprotein, og overekspression af CALM1 kan unormalt aktivere cellul\u00e6re calciumion-signaleringskanaler, hvilket i sidste ende f\u00f8rer til inflammatoriske reaktioner og en vis grad af leverskade i kroppen. CHRM1 er en parasympatisk receptor, og unders\u00f8gelser har vist, at CHRM1-agonister kan regulere neuronal differentiering ved at \u00f8ge den cellul\u00e6re calciumionaktivitet. I molekyl\u00e6r docking-validering har de lav bindingsenergi til kaempferol og kan udl\u00f8se frigivelse af inflammatoriske cytokiner ved at regulere aktiveringen af calciumionkanaler. CYP1B1 er et vigtigt protein, der er involveret i steroidhormonsyntesevejen. Steroider har betydelige antiinflammatoriske og antiallergiske immunregulerende virkninger og har vist god og stabil bindingsevne til quercetin og kaempferol i molekyl\u00e6r dockingvalidering. Fra ovenst\u00e5ende analyse kan det ses, at hovedkomponenterne i Huangqi Xinyi kan virke p\u00e5 den neuroaktive ligandreceptorinteraktionsvej, calciumion-signalvej, steroidhormonbiosyntesevej og kr\u00e6ftvej gennem m\u00e5l som PTGS2, HSP90, NOS2, CALM1, CHRM1, CYP1B1 for at ud\u00f8ve terapeutiske virkninger p\u00e5 AR. For yderligere at verificere p\u00e5lideligheden af ovenst\u00e5ende forudsigelsesresultater blev der konstrueret en AR-musemodel induceret af ragweed-pollen til in vivo-eksperimentel verifikation. Forskningsresultaterne viste, at Huangqi Xinyi-medicin kunne reducere proteinudtrykket af PTGS2, HSP90 og NOS2 i AR-mus, h\u00e6mme ekspressionsniveauerne af inflammatoriske faktorer histamin, IgE, TNF - \u03b1 og IL-6 i AR-museserum, n\u00e6seskyllev\u00e6ske og bronchoalveol\u00e6r skyllev\u00e6ske, \u00f8ge udtrykket af den antiinflammatoriske faktor IL-10, lindre AR-musens kradse- og nysesymptomer betydeligt og afsl\u00f8re, at Huangqi Xinyi-medicin kan h\u00e6mme forekomsten og udviklingen af inflammatoriske reaktioner ved at h\u00e6mme HSP90\/PTGS2\/NOS2-vejen og derved opn\u00e5 effekten af at gribe ind i AR.<br \/>\nSammenfattende blev medicinreglerne for klinisk behandling af AR opsummeret gennem statistisk datamininganalyse og netv\u00e6rksfarmakologiteknikker, og den molekyl\u00e6re mekanisme for den h\u00f8jfrekvente l\u00e6gemiddelkombination Huangqi Xinyi til behandling af AR blev grundigt unders\u00f8gt. Molekyl\u00e6r docking-simulering verificerede Huangqi Xinyis multikomponent-, multim\u00e5l- og multivejskarakteristika, og in vivo-eksperimenter bekr\u00e6ftede, at Huangqi Xinyi-l\u00e6gemidler kan h\u00e6mme forekomsten af inflammatoriske reaktioner, lindre AR-symptomer hos mus og i sidste ende opn\u00e5 effekten af behandling af AR ved at h\u00e6mme HSP90\/PTGS2\/NOS2-vejen. Resultaterne af denne unders\u00f8gelse kan give et videnskabeligt teoretisk grundlag for rationel brug af Xinyi Huangqi-medicin i klinisk praksis og yderligere fremme anvendelsen af traditionel kinesisk medicin til behandling af allergisk rhinitis.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the medication rules and related pharmacological analysis of traditional Chinese medicine in the treatment of allergic rhinitis based on data mining, network pharmacology, and experimental verification Allergic rhinitis (AR), also known as allergic rhinitis, is a chronic non infectious inflammation of the nasal mucosa caused by the release of inflammatory factors (histamine, leukotrienes, prostaglandins, [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - 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