{"id":4800,"date":"2024-08-04T15:48:24","date_gmt":"2024-08-04T15:48:24","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4800"},"modified":"2024-08-04T15:48:24","modified_gmt":"2024-08-04T15:48:24","slug":"nafld","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/nafld\/","title":{"rendered":"Fremskridt i forskningen i signalveje i forbindelse med behandling af ikke-alkoholisk fedtleversygdom med traditionel kinesisk medicin"},"content":{"rendered":"<p>Fremskridt i forskningen i signalveje i forbindelse med behandling af ikke-alkoholisk fedtleversygdom med traditionel kinesisk medicin<br \/>\nIkke-alkoholisk fedtleversygdom (NAFLD) er en levercellesteatosesygdom, der hovedsageligt er kendetegnet ved store bobler, som opst\u00e5r uden overdrevent alkoholforbrug eller leverskade. Forekomsten forts\u00e6tter med at stige og viser en tendens til yngre debut. I henhold til sv\u00e6rhedsgraden af den patologiske udvikling kan NAFLD opdeles i fire stadier: simpel fedtlever, fedthepatitis, fedtleverfibrose og fedtlevercirrhose. Kost med h\u00f8jt energiindhold, fedme, genetisk modtagelighed, genetisk polymorfisme, cytokiner og dysbiose af tarmmikrobiota er de vigtigste \u00e5rsager til NAFLD. Teorien om \"second strike\" kan delvist afsl\u00f8re mekanismen bag NAFLD. Insulinresistens (IR) f\u00f8rer til en stor ophobning af adipocytter i leverv\u00e6vet, hvilket er det f\u00f8rste angreb i patogenesen af NAFLD. De cytotoksiske reaktioner, der opst\u00e5r p\u00e5 dette grundlag, herunder oxidativ stress og inflammatoriske reaktioner, bliver det andet angreb i patogenesen af NAFLD, hvilket i sidste ende f\u00f8rer til leverfibrose. Med den fortsatte uddybning af moderne forskning giver \"multiple strikes\"-teorien en mere pr\u00e6cis forklaring p\u00e5 patogenesen af NAFLD. Denne teori mener, at cytokin og endoplasmatisk retikulum-induceret steatose og inflammatorisk respons er grundlaget for NAFLD-patogenese, og IR, lipidakkumulering, galdesyrer, genetisk polymorfisme osv. er de vigtigste faktorer, der fremkalder NAFLD. Begge ovenst\u00e5ende teorier mener, at n\u00f8glen til dannelse og udvikling af NAFLD ligger i unormal lipidmetabolisme og inflammatorisk respons. Derfor er studiet af den grundl\u00e6ggende mekanisme for unormal leverlipidmetabolisme og dannelse af inflammation i fokus for NAFLD-behandlingen.<br \/>\nLige nu findes der ingen specifik behandling af NAFLD. Moderne medicin fors\u00f8ger hovedsageligt at forbedre insulinresistens, reducere leverens fedtsyreniveauer, forbedre oxidativ stress og endoplasmatisk retikulumstress. Typerne af l\u00e6gemidler omfatter hovedsageligt insulinsensibiliserende midler, antioxidanter, cellebeskyttende midler, tumornekrosefaktor alfa (TNF - \u03b1) h\u00e6mmere osv. Men for NAFLD, is\u00e6r for patienter, der udvikler leverfibrose, skal effekten af disse l\u00e6gemidler stadig unders\u00f8ges n\u00e6rmere. Traditionel kinesisk medicin p\u00e5peger ud fra perspektiverne \"fede mennesker har mere slim og fugt\" og \"fede mennesker har mere qi-mangel\", at essensen af NAFLD for det meste er baseret p\u00e5 manglen p\u00e5 roden og manglen p\u00e5 milt og lever og stagnationen af fugt, slim og blodstasis. De almindelige syndromtyper kan opdeles i modstand mod fugt og uklarhed, ophobning af fugtig varme, leverdepression og miltmangel og stase af slim og blod. Behandlingsmetoderne fokuserer hovedsageligt p\u00e5 at berolige leveren og milten, l\u00f8se op for slim og fugt, fjerne varme og fugt samt fremme blodcirkulationen og fjerne blodstase. NAFLD er en kronisk sygdom med et langt og vedvarende forl\u00f8b. Traditionel kinesisk medicin (TCM) har udviklet sit eget system til forebyggelse og behandling af NAFLD, baseret p\u00e5 principperne om at \"behandle sygdomme ved roden\", \"s\u00e6tte mennesket f\u00f8rst\" og \"behandle ud fra syndromdifferentiering\". Et stort antal eksperimenter har vist, at den oprindelige fordel ved traditionel kinesisk medicin til behandling af NAFLD gennem multim\u00e5l- og multivejsterapi er fremragende effektivitet og universel anvendelighed. Denne artikel opsummerer de f\u00e6lles signalveje for traditionel kinesisk medicin i behandlingen af NAFLD med hensyn til lipidmetabolisme og inflammatorisk respons, hvilket giver et teoretisk grundlag for klinisk behandling og eksperimentel forskning.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4801\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-95.png\" alt=\"\" width=\"661\" height=\"401\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4802\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-83.png\" alt=\"\" width=\"655\" height=\"400\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4803\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-78.png\" alt=\"\" width=\"660\" height=\"681\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4804\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-66.png\" alt=\"\" width=\"664\" height=\"719\" \/>Sammenfattende er lipidmetabolisme og inflammatorisk respons to vigtige m\u00e5l for traditionel kinesisk medicins behandling af NAFLD. Traditionel kinesisk medicin reducerer lipidaflejring ved at formidle signalveje som FXR, PPAR \u03b1, G-protein og regulere galdesyremetabolismen. Den reducerer ogs\u00e5 inflammatorisk respons og oxidativ stress ved at formidle signalveje som NF-\u03ba B, Nrf2, Th17\/Treg, JNK, hvilket i sidste ende forebygger og behandler udviklingen af NAFLD (se tabel 1 for detaljer). Derudover har de fleste traditionelle kinesiske l\u00e6gemidler og sammensatte formler den virkning, at de fjerner varme, beroliger leveren, fjerner blodstasis, fordriver fugt og giver n\u00e6ring til kroppen, hvilket er i overensstemmelse med \u00e6tiologien og patogenesen af NAFLD i traditionel kinesisk medicin. Traditionel kinesisk medicin giver en omfattende behandling af NAFLD ud fra et holistisk, flerdimensionelt og flerm\u00e5lsorienteret perspektiv, og dens effektivitet og sikkerhed er ogs\u00e5 blevet bredt anerkendt.<br \/>\nMen forfatteren fandt gennem litteraturs\u00f8gning, at traditionel kinesisk medicinbehandling for NAFLD ogs\u00e5 har mange mangler. For det f\u00f8rste afspejler unders\u00f8gelsen af formelterapi for NAFLD ofte de omfattende virkninger af forskellige l\u00e6gemidler med komplekse p\u00e5virkningsfaktorer, uklare specifikke aktive ingredienser og virkningsmekanismer og mangel p\u00e5 dybtg\u00e5ende mekanismeforskning. For det andet mangler nogle signalveje, der er involveret i behandlingen af NAFLD med traditionel kinesisk medicin, udforskende forskning og autoritativ teoretisk st\u00f8tte, og grundl\u00e6ggende eksperimentel forskning og efterf\u00f8lgende klinisk anvendelsesforskning er relativt utilstr\u00e6kkelig. Endnu en gang involverer traditionel kinesisk medicin flere signalveje i behandlingen af NAFLD, og hver vej fungerer ikke uafh\u00e6ngigt. Mangfoldigheden af signalveje, og om der er antagonistiske og synergistiske forhold mellem dem, samt om der er andre p\u00e5virkningsfaktorer og relaterede veje, er stadig sp\u00f8rgsm\u00e5l, som vi er n\u00f8dt til at udforske. Derfor er flere forskere n\u00f8dt til at udf\u00f8re dybdeg\u00e5ende forskning i deres m\u00e5l og mekanismer for at give teknisk og teoretisk st\u00f8tte til fremtidig klinisk medicinering.<\/p>","protected":false},"excerpt":{"rendered":"<p>Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine Non alcoholic fatty liver disease (NAFLD) is a liver cell steatosis disease mainly characterized by large bubbles, which occurs without excessive alcohol consumption or liver damage. Its incidence continues to increase and shows a trend of younger [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/nafld\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research progress on signaling pathways related to the treatment of non-alcoholic fatty liver disease with traditional Chinese medicine Non alcoholic fatty liver disease (NAFLD) is a liver cell steatosis disease mainly characterized by large bubbles, which occurs without excessive alcohol consumption or liver damage. 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