{"id":4718,"date":"2024-08-04T15:16:25","date_gmt":"2024-08-04T15:16:25","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4718"},"modified":"2024-08-04T15:16:25","modified_gmt":"2024-08-04T15:16:25","slug":"icariin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/icariin\/","title":{"rendered":"Regulerende effekt af icariin p\u00e5 f\u00e6notypetransformation af mikroglia i depressionsmodel"},"content":{"rendered":"<p>Regulerende effekt af icariin p\u00e5 f\u00e6notypetransformation af mikroglia i depressionsmodel<br \/>\nDepression er en slags f\u00f8lelsesm\u00e6ssig psykisk lidelse med en h\u00f8j forekomst, som er let at f\u00e5 tilbage og endda livstruende i alvorlige tilf\u00e6lde. Det er blevet et globalt folkesundhedsproblem. De kliniske manifestationer af depressionspatienter omfatter hovedsageligt depressive f\u00f8lelser, nedsat gl\u00e6de, f\u00f8lelser af v\u00e6rdil\u00f8shed eller skyld og selvmordstanker. P\u00e5 grund af de komplekse biologiske mekanismer og involvering af mange systemer er depressionens patogenese ikke fuldt ud forst\u00e5et, og forskning i antidepressiva er et globalt fokus, men fremskridtene er langsomme. At finde nye tilgange og l\u00e6gemiddelm\u00e5l til behandling af depression er blevet et presserende sp\u00f8rgsm\u00e5l.<br \/>\nDet neuroinflammatoriske respons for\u00e5rsaget af stress bliver i stigende grad anerkendt i patogenesen af depression. Mikroglia er en type medf\u00f8dt immuncelle i centralnervesystemet, der er t\u00e6t forbundet med neuroinflammatoriske reaktioner i hjernen, og som har potentiale til at blive et nyt terapeutisk m\u00e5l. Den klassiske M1-polarisering frigiver inflammatoriske faktorer som interleukin-6 (IL6), interleukin-1 (IL-1), tumornekrosefaktor alfa (TNF - \u03b1) osv., hvilket for\u00e5rsager neuroinflammatoriske reaktioner; Erstat aktiveret M2-polarisering, udskiller interleukin-10 (interle, ukin-10, IL-10), transformerende v\u00e6kstfaktor beta (TGF - \u03b2) osv., fremkalder v\u00e6vsreparation og ud\u00f8ver neurobeskyttende effekter. Regulering af mikroglias f\u00e6notypetransformation er en af de vigtigste m\u00e5der at gribe ind i forekomsten og udviklingen af depression. Traditionel kinesisk medicin har altid haft betydelige fordele i forbindelse med forebyggelse og behandling af depression. I traditionel kinesisk medicin er nyre yang-mangel en af de vigtige mekanismer for depression, og behandlingen af depression fra perspektivet af nyreteori giver ideer. I klinisk praksis kombineres Epimedium, en traditionel kinesisk medicin til toning af nyre-yang, ofte med andre kinesiske l\u00e6gemidler som Xianmao, Morinda officinalis og Yejiaoteng til behandling af depression af typen nyre-yang-mangel. I tidligere unders\u00f8gelser blev det observeret, at icariin, den aktive ingrediens i Epimedium brevicomu Maxim, en traditionel kinesisk medicin til toning af nyre-yang, har gode antidepressive virkninger, men dens mekanisme er stadig uklar. Denne unders\u00f8gelse har til hensigt at bruge en kronisk uforudsigelig mild stressinduceret depressionsmodel kombineret med en lipopolysakkarid (LPS)-induceret BV-2-cellepolariseringsmodel til at udforske mekanismen bag icariins antidepressive virkning.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4719\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-85.png\" alt=\"\" width=\"936\" height=\"394\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-85.png 936w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-85-768x323.png 768w\" sizes=\"(max-width: 936px) 100vw, 936px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4720\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-75.png\" alt=\"\" width=\"1166\" height=\"436\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-75.png 1166w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-75-768x287.png 768w\" sizes=\"(max-width: 1166px) 100vw, 1166px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4722\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-3.jpg\" alt=\"\" width=\"1166\" height=\"381\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-3.jpg 1166w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-3-768x251.jpg 768w\" sizes=\"(max-width: 1166px) 100vw, 1166px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4723\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-58.png\" alt=\"\" width=\"1166\" height=\"698\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-58.png 1166w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-58-768x460.png 768w\" sizes=\"(max-width: 1166px) 100vw, 1166px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4724\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-57.png\" alt=\"\" width=\"1166\" height=\"610\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-57.png 1166w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-57-768x402.png 768w\" sizes=\"(max-width: 1166px) 100vw, 1166px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4725\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-4.jpg\" alt=\"\" width=\"1063\" height=\"962\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-4.jpg 1063w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-4-768x695.jpg 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-4-796x720.jpg 796w\" sizes=\"(max-width: 1063px) 100vw, 1063px\" \/><br \/>\nDepression er en alvorlig psykisk sygdom, som mangler ideelle behandlingsmetoder p\u00e5 grund af dens komplekse patogenese. Traditionel kinesisk medicin har sine egne karakteristika og fordele i behandlingen af depression. P\u00e5 nuv\u00e6rende tidspunkt er depressionens patogenese ikke fuldt ud forst\u00e5et. De hypoteser, der i \u00f8jeblikket er dannet, inkluderer hovedsageligt: inflammatorisk immunitetshypotese, hypothalamisk hypofyse-binyre (HPA) aksedysfunktionshypotese, monoamin-neurotransmitterhypotese, neurotrofisk faktorhypotese osv. Med uddybningen af forskningen har den inflammatoriske immunitetshypotese f\u00e5et stor opm\u00e6rksomhed b\u00e5de nationalt og internationalt. Forskning har vist, at patienter med depression ikke kun oplever perifere bet\u00e6ndelsesreaktioner, men ogs\u00e5 immunaktivering af centralnervesystemet. Mikroglia er en vigtig type immuncelle i centralnervesystemet, som er t\u00e6t forbundet med centralnervesystemets inflammatoriske respons. Under langvarig stress er deres struktur og funktion unormal, hvilket f\u00f8rer til \u00e6ndringer i f\u00f8lelser og mentale tilstande, som er vigtige faktorer i forekomsten og udviklingen af depression.<br \/>\nKlassisk aktiveringstype (M1-type) og alternativ aktiveringstype (M2-type) er de to vigtigste polariseringsf\u00e6notyper for mikroglia. M1-typen udg\u00f8r langt st\u00f8rstedelen af de aktiverede celler og kan syntetisere og udskille proinflammatoriske mediatorer som TNF - \u03b1, IL-1, IL-6 og nitrogenoxidsyntase iNOS, hvilket udl\u00f8ser en immuninflammatorisk kaskadereaktion; M2-type (tre undertyper M2a, M2b immunf\u00e6notype, M2c inaktiv f\u00e6notype) kan stimuleres af interleukin-4 (IL-4), interleukin-13 (IL-13) og andre faktorer, der frigiver antiinflammatoriske faktorer som IL-10 og CD206, ud\u00f8ver antiinflammatoriske og neurobeskyttende funktioner og spiller en vigtig rolle i hjernens nervereparation og plasticitet. Dyrefors\u00f8g har vist, at mikroglia i den pr\u00e6frontale cortex hos mus og rotter, der uds\u00e6ttes for CUMS, er st\u00e6rkt aktiveret og ledsaget af et h\u00f8jt udtryk for relaterede inflammatoriske mediatorer, hvilket kan f\u00f8re til inflammationsrelateret neuronal degeneration i forbindelse med depression. En post mortem-unders\u00f8gelse viste, at hos patienter med sv\u00e6r depression var t\u00e6theden af mikroglia i den forreste cingul\u00e6re cortex og det hvide stofomr\u00e5de i den ventrale pr\u00e6frontallap markant \u00f8get og viste en aktiveret tilstand, men den typiske mark\u00f8r for M2-mikroglia, CD206, var markant nedreguleret. Ovenst\u00e5ende forskning tyder p\u00e5, at overdreven aktivering af mikroglia og polarisering af M1- og M2-mikroglia spiller en vigtig rolle i forekomsten og udviklingen af depression.<\/p>\n<p>Denne unders\u00f8gelse viste, at i hippocampus hos CUMS-inducerede depressionsmus var niveauerne af proinflammatorisk cytokin IL-6 forh\u00f8jet, og IL-6 mRNA, iNOS mRNA og iNOS-protein blev overudtrykt, ledsaget af en stigning i depressiv lignende adf\u00e6rd (\u00f8get tvungen sv\u00f8mmeimmobilitetstid, reduceret sukkervandforbrug og tr\u00e6ningsafstand), hvilket tyder p\u00e5 en signifikant stigning i klassisk aktiveret M1-mikroglia i hippocampus hos depressionsmus. Epimediumglykosid kan h\u00e6mme aktivering af mikroglia af M1-typen, reducere niveauerne af det proinflammatoriske cytokin IL-6, mindske overekspression af IL-6 mRNA, iNOS mRNA og iNOS-protein og undertrykke hjernebet\u00e6ndelse hos modelmus; P\u00e5 den anden side kan icariin fremme M2-aktivering af mikroglia, \u00f8ge IL-10-niveauer i hippocampus hos CUMS-eksponerede mus, fremme IL-10 mRNA, CD206 mRNA og CD206-proteinekspression og derved h\u00e6mme depressionslignende adf\u00e6rd hos modelmus. In vitro-eksperimenter viste ogs\u00e5, at M1-polarisering af mikroglia steg under LPS-stimulering, og icariin kunne h\u00e6mme M1-polarisering af mikroglia og fremme M2-polarisering. Dette tyder p\u00e5, at icariin lindrer overdreven neuroinflammation ved at regulere den f\u00e6notypiske transformation af mikroglia.<\/p>\n<p>De metaboliske forstyrrelser af monoamin-neurotransmitterne 5-HT, DA og NE er t\u00e6t forbundet med forekomsten og udviklingen af neurologiske og psykiatriske lidelser som f.eks. depression. Niveauerne af monoamin-neurotransmitterne 5-HT, DA og NE i hjernen hos rotter med CUMS-induceret depression var betydeligt reduceret. Rehmannia glutinosa kan s\u00e6nke niveauerne af 5-HT, DA og NE i modelrotternes hippocampus og forbedre den depressive adf\u00e6rd. Danshen-polyphenolsyre kan effektivt forbedre depressionslignende adf\u00e6rd hos rotter, muligvis ved at h\u00e6mme signalvejen non-receptortyrosinkinase 2 (Janus kinase 2)\/signaltransducer og aktivator af transkription 3 (STAT3), lindre neuroinflammation og regulere niveauerne af monoamin-neurotransmittere. Flere og flere immunceller - mikroglia. Aktiverede mikroglia inducerer frigivelse af mange inflammatoriske faktorer s\u00e5som interleukin-1 \u03b2 (IL-1 \u03b2), TNF - \u03b1, TGF - \u03b2 osv. Disse inflammatoriske faktorer kan p\u00e5virke funktionen af monoamin-neuroner og fremkalde et fald i monoamin-neurotransmission gennem oxidativ stress, som anses for at v\u00e6re en vigtig faktor i depression. Det er blevet bekr\u00e6ftet, at monoaminl\u00e6gemidler kan blokere aktiveringen af mikroglia og vende depressionen p\u00e5 en eller anden m\u00e5de. Forskning har vist, at tetrahydrobiopterin (BH4), som er en anerkendt biomark\u00f8r for depression, er en vigtig enzymatisk kofaktor, der er n\u00f8dvendig for syntesen af 5-HT, DA og NE. BH4-mangel kan f\u00f8re til depression. M1-type mikroglia kan f\u00f8re til BH4-katabolisme. H\u00e6mning af M1-polarisationen i mikroglia kan begr\u00e6nse BH4-katabolismen og fremme syntesen og udskillelsen af monoamin-neurotransmittere. Resultaterne af denne unders\u00f8gelse viste, at et fald i monoamin-neurotransmittere i hippocampus i den CUMS-inducerede musedepressionsmodel var ledsaget af en stigning i depressiv adf\u00e6rd. Epimediumglykosid kan \u00f8ge niveauet af monoamin-neurotransmittere i hippocampus hos modelmus, hvilket kan v\u00e6re en af mekanismerne bag dets antidepressive virkning, hvilket er i overensstemmelse med tidligere rapporter. Men om icariin fremmer syntesen og udskillelsen af monoamin-neurotransmittere i hippocampus hos depressionsmodelmus ved at regulere f\u00e6notypetransformationen af mikroglia, skal stadig unders\u00f8ges n\u00e6rmere.<\/p>\n<p>Sammenfattende brugte denne unders\u00f8gelse CUMS til at etablere en musemodel for depression og en LPS-induceret polarisationsmodel for mikroglia. Det viste sig, at icariin, en aktiv ingrediens i den traditionelle kinesiske medicin Epimedium til toning af nyre-yang, h\u00e6mmer M1-polarisering og fremmer M2-polarisering af mikroglia, reducerer inflammation i hippocampus hos deprimerede mus og fremmer produktionen af monoamin-neurotransmittere, hvilket er en af dets mekanismer for antidepressiv virkning.<\/p>","protected":false},"excerpt":{"rendered":"<p>Regulatory effect of icariin on phenotype transformation of microglia in depression model Depression is a kind of emotional mental disorder, with a high incidence of incidence rate, which is easy to recur, and even life-threatening in serious cases. It has become a global public health problem. The clinical manifestations of depression patients mainly include depressive [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Regulatory effect of icariin on phenotype transformation of microglia in depression model - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/icariin\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Regulatory effect of icariin on phenotype transformation of microglia in depression model - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Regulatory effect of icariin on phenotype transformation of microglia in depression model Depression is a kind of emotional mental disorder, with a high incidence of incidence rate, which is easy to recur, and even life-threatening in serious cases. 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It has become a global public health problem. 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