{"id":4500,"date":"2024-08-04T14:36:23","date_gmt":"2024-08-04T14:36:23","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4500"},"modified":"2024-08-04T14:36:23","modified_gmt":"2024-08-04T14:36:23","slug":"phytoglycogen-loading","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/phytoglycogen-loading\/","title":{"rendered":"Hvordan forbedrer fytoglykogen-belastning opl\u00f8seligheden af curcumin?"},"content":{"rendered":"<p><strong>Curcumin<\/strong><\/p>\n<p>Curcumin (CCM) er en polyfenolisk forbindelse, der udvindes af gurkemejeplanter som Curcuma longa, Curcuma longa, Ulmoides osv. Det er et naturligt spiseligt gult pigment, som er tilladt at bruge b\u00e5de herhjemme og i udlandet.<\/p>\n<p>I mellemtiden har CCM forskellige fysiologiske og farmakologiske aktiviteter, s\u00e5som antibakterielle, antitumor-, anti-human immunodeficiency virus-effekter, antifibrotiske effekter osv. Det er varmebestandigt og sikkert (ingen \u00e5benlyse toksiske bivirkninger p\u00e5 menneskekroppen ved en dosis p\u00e5 12 g\/d).<\/p>\n<p>CCM's vandopl\u00f8selighed er dog meget lav (11 ng\/mL, 25 \u00b0C), hvilket f\u00f8rer til d\u00e5rlig absorption og lav biotilg\u00e6ngelighed i kroppen, og dets anvendelse inden for relaterede omr\u00e5der som f\u00f8devarer og l\u00e6gemidler med vandopl\u00f8selige matricer er s\u00e5ledes st\u00e6rkt begr\u00e6nset. Derfor er en forbedring af CCM's vandopl\u00f8selighed n\u00f8glen til at udvikle dets potentielle anvendelsesv\u00e6rdi.<\/p>\n<p>I \u00f8jeblikket, <strong>Metoder til at forbedre CCM's opl\u00f8selighed omfatter en r\u00e6kke teknikker eller systemer baseret p\u00e5 liposomer, miceller, nanoemulsioner, amorfe faste dispersioner, kemisk modifikation af CCM og dannelse af komplekser med b\u00e6rematerialer, herunder naturlige polymerer (kulhydrater, proteiner og fedtstoffer) og syntetiske polymerer.<\/strong>.<\/p>\n<p><strong>De fleste af ovenst\u00e5ende metoder er dog ikke nemme at anvende p\u00e5 f\u00f8devarer.<\/strong>F.eks. kr\u00e6ves der et stort antal overfladeaktive stoffer til fremstilling af liposomer; de fleste naturlige polymerer skal modificeres, og syntetiske polymerer har normalt lav biokompatibilitet. Der er ogs\u00e5 problemer med den komplicerede fremstillingsproces og de h\u00f8je omkostninger.<\/p>\n<p><strong>Fytoglykogen<\/strong><\/p>\n<p>Fytoglykogen (PG) er et st\u00e6rkt forgrenet opl\u00f8seligt \u03b1-D-glucan, der er forbundet med \u03b1-1,4- og \u03b1-1,6-glycosidbindinger. P\u00e5 grund af den korte gennemsnitlige k\u00e6del\u00e6ngde, den h\u00f8je grad af forgrening og de strukturelle tr\u00e6k s\u00e5som stramt ydre og l\u00f8st indre dendritisk forgreningsm\u00f8nster og lille partikelst\u00f8rrelse er der et stort antal glukoserester til stede p\u00e5 molekylets overflade, og det er opl\u00f8seligt i koldt vand p\u00e5 grund af dannelsen af hydrogenbindinger med vandmolekyler. Det er let opl\u00f8seligt i koldt vand.<\/p>\n<p>Unders\u00f8gelser har vist, at PG ikke indeholder en klyngestruktur, men danner en sf\u00e6risk struktur med flere og kortere grene og en strammere struktur end forgrenet stivelse, hvilket g\u00f8r <strong>Det er en naturlig nanopartikel.<\/strong><\/p>\n<p>Chen et al. fyldte lutein og quercetin med PG og <strong>\u00f8gede den tilsyneladende opl\u00f8selighed af lutein (0,56 \u03bcg\/mL steg til 130,65 \u03bcg\/mL) og quercetin (4,32 \u03bcg\/mL steg til 241,76 \u03bcg\/mL) betydeligt.<\/strong><\/p>\n<p>I denne unders\u00f8gelse, baseret p\u00e5 de egenskaber, at PG er let at sprede og opl\u00f8se i koldt vand og har god dispersionsstabilitet, blev en vis m\u00e6ngde st\u00e6rkt koncentreret CCM-ethanolopl\u00f8sning tilsat til en vis koncentration af PG-vandig opl\u00f8sning med PG som b\u00e6rer, hvilket gjorde systemet overm\u00e6ttet med CCM.<\/p>\n<p>Nogle af de frie CCM-molekyler interagerede med PG og dannede et fytoglykogen-curcumin-kompleks (PG-CCM), som forbedrede CCM's tilsyneladende opl\u00f8selighed.<\/p>\n<p><strong>Konklusion.<\/strong><\/p>\n<p>PG er en ny nanopartikelb\u00e6rer, der indl\u00e6ser CCM p\u00e5 en selvsamlet m\u00e5de for at danne PG-CCM-komplekse nanopartikler. Indl\u00e6sningsmetoden er enkel og let uden tils\u00e6tningsstoffer, og CCM's tilsyneladende opl\u00f8selighed kan \u00f8ges ca. 2700 gange efter indl\u00e6sning.<\/p>\n<p>PG og CCM kan interagere med hinanden gennem intermolekyl\u00e6r hydrogenbinding, og der er ingen signifikant \u00e6ndring i partikelst\u00f8rrelsen af PG fyldt med CCM, med en gennemsnitlig partikelst\u00f8rrelse p\u00e5 70-75 nm, hvor CCM findes i en amorf og ikke-krystallinsk tilstand i PG-CCM-komplekserne, og hydrogenbinding er den vigtigste kraft for interaktionen mellem CCM og b\u00e6rer-PG, og CCM flyttes fra mikromilj\u00f8et med st\u00f8rre polaritet til regionen med mindre polaritet, hvor PG interagerer.<\/p>\n<p>Vores resultater tyder p\u00e5, at PG er en effektiv b\u00e6rer, der kan \u00f8ge den tilsyneladende opl\u00f8selighed af CCM betydeligt, og PG-CCM-komplekset er nemt at fremstille og forventes at blive indarbejdet i funktionelle f\u00f8devarer for at fremme de farmakologiske virkninger af CCM.<\/p>","protected":false},"excerpt":{"rendered":"<p>Curcumin Curcumin (CCM) is a polyphenolic compound extracted from turmeric plants such as Curcuma longa, Curcuma longa, Ulmoides, etc. It is a natural edible yellow pigment allowed to be used both at home and abroad. Meanwhile, CCM has various physiological and pharmacological activities, such as antibacterial, antitumor, anti-human immunodeficiency virus effects, antifibrotic effects, etc. It [&hellip;]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How does phytoglycogen loading improve curcumin solubility? - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/phytoglycogen-loading\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How does phytoglycogen loading improve curcumin solubility? - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Curcumin Curcumin (CCM) is a polyphenolic compound extracted from turmeric plants such as Curcuma longa, Curcuma longa, Ulmoides, etc. It is a natural edible yellow pigment allowed to be used both at home and abroad. 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