{"id":3943,"date":"2024-08-03T14:20:47","date_gmt":"2024-08-03T14:20:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3943"},"modified":"2024-08-03T14:20:47","modified_gmt":"2024-08-03T14:20:47","slug":"uplc-q-tof-ms-ms-and-network-pharmacology","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/uplc-q-tof-ms-ms-and-network-pharmacology\/","title":{"rendered":"Udforskning af Taro acuminatas mekanisme mod brystkr\u00e6ft baseret p\u00e5 UPLC-Q-TOF-MS\/MS og netv\u00e6rksfarmakologi"},"content":{"rendered":"<p>Udforskning af Taro acuminatas mekanisme mod brystkr\u00e6ft baseret p\u00e5 UPLC-Q-TOF-MS\/MS og netv\u00e6rksfarmakologi<br \/>\nP\u00e5 verdensplan tegner brystkr\u00e6ft sig for 10% af forekomsten af alle kr\u00e6ftformer og 15% af den tumorrelaterede d\u00f8delighed blandt kvinder. Den seneste Global Cancer Report 2020 udgivet af Verdenssundhedsorganisationen viser, at 2,1 millioner nye brystkr\u00e6fttilf\u00e6lde og 27.000 mennesker d\u00f8de af brystkr\u00e6ft i 2018, hvilket udg\u00f8r en alvorlig trussel mod menneskers sundhed. Derfor er effektiv behandling af brystkr\u00e6ft s\u00e6rlig vigtig. If\u00f8lge teorien om syndromdifferentiering og -behandling har traditionel kinesisk medicin en indlysende helbredende effekt p\u00e5 brystkr\u00e6ft ved at justere kroppens funktioner, s\u00e5som yin, yang, qi, blod, indvolde og meridianer. Traditionel kinesisk medicin kan forbedre kroppens stofskifte, regulere den overordnede funktion af patientens krop og reducere tilbagefald og metastase af brystkr\u00e6ft for at forbedre den kliniske effekt.<br \/>\nRoden og st\u00e6nglen af Alocassia cuculata (Lour.) Schott, en plante i Araceae-familien, er en traditionel folkemedicin, der har den virkning, at den fjerner varme, afgifter, reducerer h\u00e6velse og lindrer smerte. Moderne farmakologiske unders\u00f8gelser har vist, at taro kan aktivere immunfaktorer til at h\u00e6mme aktiviteten af forskellige tumorceller som f.eks. melanom, forbedre kroppens immunforsvar, fremkalde apoptose af kr\u00e6ftceller og ud\u00f8ve antitumoreffekter. De relaterede molekyl\u00e6re mekanismer involverer signalveje som MAPK og PI3K Akt. Det er rapporteret i litteraturen, at petroleumsetherfraktion af Alocasia cucullata (EAC) kan h\u00e6mme spredningen af brystkr\u00e6ft MDA-MB-231-celler i in vitro-celleeksperimenter. Mekanismen er relateret til h\u00e6mning af p-ERK\/ERK-ekspression i MAPK-vejen. Samtidig er petroleumsetherfraktionen af Alocasia cucullata rig p\u00e5 forskellige um\u00e6ttede fedtsyrer s\u00e5som linolsyre og forskellige fytosteroler s\u00e5som \u03b3-sitosterol gennem GC-MS-analyse. Moderne forskning viser, at um\u00e6ttede fedtsyrer som linolsyre og fytosteroler kan fremkalde apoptose af brystkr\u00e6ftceller ved at regulere niveauet af Bax\/Bcl-2. Dette tyder p\u00e5, at mekanismen mod brystkr\u00e6ft i petroleumsetherfraktionen af taro ogs\u00e5 kan v\u00e6re relateret til reguleringen af Bax\/Bcl-2-niveauet. P\u00e5 nuv\u00e6rende tidspunkt er forskningen i den kemiske sammens\u00e6tning af petroleumsetherdelen af Taro acuminata dog kun begr\u00e6nset til GC-MS-analyse, og der findes ingen relevant rapport om mekanismen for den brystkr\u00e6fth\u00e6mmende virkning af petroleumsetherdelen af Taro acuminata in vivo. Forskningen i det materielle grundlag for dets effektivitet og mekanismen for virkning mod brystkr\u00e6ft in vivo er relativt svag. V\u00e6ksttilstanden og metastasestedet for 4T1-celletransplantationstumormodellen kan godt simulere human avanceret brystkr\u00e6ft og blive en god model til evaluering af l\u00e6gemidler til avanceret brystkr\u00e6ft. Derfor blev petroleumsetherdelen af Taro acuminata i denne artikel taget som forskningsobjekt, og den kemiske sammens\u00e6tning af petroleumsetherdelen af Taro acuminata blev bestemt gennem UPLC-Q-TOF-MS\/MS, mens netv\u00e6rksfarmakologistrategien kombineret med molekyl\u00e6r dockingteknologi blev brugt til at afklare det molekyl\u00e6re niveau af antibrystkr\u00e6ftmekanismen for petroleumsetherdelen af Taro acuminata. Endelig blev antibrystkr\u00e6fteffekten af petroleumsetherdelen af Taro acuminata acuminata in vivo evalueret gennem den 4T1 brystkr\u00e6fttumorb\u00e6rende musemodel, og dens antibrystkr\u00e6ftmekanisme blev verificeret. For at give eksperimentelle referencer til den dybtg\u00e5ende forskning og udvikling af den spidse hale taro.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3948\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png\" alt=\"\" width=\"1178\" height=\"350\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png 1178w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23-768x228.png 768w\" sizes=\"(max-width: 1178px) 100vw, 1178px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3949\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-21.png\" alt=\"\" width=\"1096\" height=\"518\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-21.png 1096w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-21-768x363.png 768w\" sizes=\"(max-width: 1096px) 100vw, 1096px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3950\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20.png\" alt=\"\" width=\"914\" height=\"1150\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20.png 914w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20-768x966.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20-572x720.png 572w\" sizes=\"(max-width: 914px) 100vw, 914px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3951\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19.png\" alt=\"\" width=\"928\" height=\"898\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19.png 928w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19-768x743.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19-744x720.png 744w\" sizes=\"(max-width: 928px) 100vw, 928px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3952\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-17.png\" alt=\"\" width=\"770\" height=\"436\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-17.png 770w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-17-768x435.png 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3953\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-16.png\" alt=\"\" width=\"748\" height=\"422\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3954\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-15.png\" alt=\"\" width=\"770\" height=\"450\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-15.png 770w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-15-768x449.png 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3955\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-11.png\" alt=\"\" width=\"768\" height=\"460\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3956\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-8.png\" alt=\"\" width=\"824\" height=\"460\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-8.png 824w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-8-768x429.png 768w\" sizes=\"(max-width: 824px) 100vw, 824px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3957\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-5.png\" alt=\"\" width=\"768\" height=\"448\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3958\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4.png\" alt=\"\" width=\"794\" height=\"312\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4.png 794w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4-768x302.png 768w\" sizes=\"(max-width: 794px) 100vw, 794px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3959\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-4.png\" alt=\"\" width=\"814\" height=\"468\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-4.png 814w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-4-768x442.png 768w\" sizes=\"(max-width: 814px) 100vw, 814px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3960\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-4.png\" alt=\"\" width=\"824\" height=\"468\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-4.png 824w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-4-768x436.png 768w\" sizes=\"(max-width: 824px) 100vw, 824px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3961\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-4.png\" alt=\"\" width=\"798\" height=\"470\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-4.png 798w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-4-768x452.png 768w\" sizes=\"(max-width: 798px) 100vw, 798px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3962\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-3.png\" alt=\"\" width=\"900\" height=\"400\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-3.png 900w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-3-768x341.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3963\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-3.png\" alt=\"\" width=\"924\" height=\"208\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-3.png 924w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-3-768x173.png 768w\" sizes=\"(max-width: 924px) 100vw, 924px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3964\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-3.png\" alt=\"\" width=\"766\" height=\"526\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3965\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-3.png\" alt=\"\" width=\"934\" height=\"594\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-3.png 934w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-3-768x488.png 768w\" sizes=\"(max-width: 934px) 100vw, 934px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3966\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-3.png\" alt=\"\" width=\"745\" height=\"631\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3967\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-3.png\" alt=\"\" width=\"924\" height=\"456\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-3.png 924w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-3-768x379.png 768w\" sizes=\"(max-width: 924px) 100vw, 924px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3968\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-2.png\" alt=\"\" width=\"940\" height=\"342\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-2.png 940w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-2-768x279.png 768w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3969\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/22-1.png\" alt=\"\" width=\"956\" height=\"620\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/22-1.png 956w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/22-1-768x498.png 768w\" sizes=\"(max-width: 956px) 100vw, 956px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3970\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/23-1.png\" alt=\"\" width=\"944\" height=\"544\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/23-1.png 944w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/23-1-768x443.png 768w\" sizes=\"(max-width: 944px) 100vw, 944px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3971\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/24-1.png\" alt=\"\" width=\"776\" height=\"357\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/24-1.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/24-1-768x353.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>Denne unders\u00f8gelse brugte UPLC-Q-TOF-MS\/MS-teknologi til at analysere 41 kemiske komponenter i petroleumsetherfraktionen af taro. Samtidig blev 32 aktive ingredienser mod brystkr\u00e6ft og 556 m\u00e5l mod brystkr\u00e6ft analyseret fra petroleumsetherfraktionen af Tara acuminata gennem en netv\u00e6rksfarmakologisk strategi. 40 kernem\u00e5l som MAPK1 og Bcl-2 blev forudsagt af PPI-netv\u00e6rket, og disse m\u00e5l var hovedsageligt koncentreret i MAPK-proteinfamilien og PI3K-proteinfamilien. Desuden viste GO-biologisk procesberigelsesanalyse, at den biologiske proces mod brystkr\u00e6ft af petroleumsetherfraktion af Tara acuminata hovedsageligt var involveret i negativ regulering af celleapoptose og andre biologiske processer. Berigelsesanalysen af KEGG-signalvejen viste, at m\u00e5lberigelsen mod brystkr\u00e6ft af petroleumsetherfraktion af Tara acuminata hovedsagelig var i PI3K-Akt- og MAPK-signalveje, som begge var relateret til celleapoptose. PPI-netv\u00e6rket forudsagde, at MAPK1, Bcl-2 og andre apoptoserelaterede kernem\u00e5l blev opn\u00e5et, og yderligere verificeret ved molekyl\u00e6r docking-teknologi, at sterolkomponenten digitalisglykosidligand, fedtsyrekomponenten linolensyre og kumarinkomponenten 7-hydroxycoumarin kunne binde frit (bindingsenergi&lt;0 kcal\/mol) med de relaterede kernem\u00e5l (p-ERK, Bcl-2, Bax) af petroleumsether-delen af Amorphophallus senticosus til brystkr\u00e6ft. Ovenst\u00e5ende resultater tyder p\u00e5, at antibrystkr\u00e6fteffekten af petroleumsetherfraktionen af taro er relateret til dens multikomponent- og multim\u00e5l-egenskaber, og dens antibrystkr\u00e6ftmekanisme er relateret til apoptoserelaterede signalveje s\u00e5som PI3K Akt og MAPK.<\/p>\n<p>Jianwei-taro bruges ofte i folkemedicin til behandling af forskellige kr\u00e6ftformer, og forbindelserne i knoldene kan h\u00e6mme v\u00e6ksten af forskellige kr\u00e6ftceller. Vores forskningsgruppes tidligere forskning viste, at vandekstraktet af taro kan h\u00e6mme v\u00e6ksten af brystkr\u00e6ft og forl\u00e6nge overlevelsesperioden for brystkr\u00e6ftmus ved at \u00f8ge aktiviteten af musemiltceller. Celleeksperimentet viste, at taro i betydelig grad kan katalysere differentieringen af immunmonocytter til makrofager, stimulere funktionen af megafagocytter og aktivere immunsystemet for at opn\u00e5 antitumoreffekt. Petroleums\u00e6terfraktionen af taro kan h\u00e6mme v\u00e6ksten af humane MDA-MB-231 brystkr\u00e6ftceller og fremme apoptose af kr\u00e6ftceller. Resultaterne af dette eksperiment viste, at petroleumsetherfraktionen af taro kan h\u00e6mme v\u00e6ksten af brystkr\u00e6ft i tumorb\u00e6rende mus, reducere tumorv\u00e6gten, og tumorinhiberingshastigheden viste en koncentrationsafh\u00e6ngig tendens. Milten er et vigtigt immunorgan hos dyr, som kan afspejle l\u00e6gemidlers indvirkning p\u00e5 immunsystemet. Musene i mellem- og h\u00f8jdosisgrupperne af EAC administreret oralt havde h\u00f8jere miltindeks og signifikante forskelle sammenlignet med modelgruppemusene, hvilket indikerer, at petroleumsetherfraktionen af taro kan forbedre immunfunktionen hos tumorb\u00e6rende mus. HE-farvningsresultaterne af tumorv\u00e6v viste, at tumorcellerne i modelgruppen af mus voksede t\u00e6t, mens 5-fluorouracil-gruppen og gruppen behandlet med taro havde l\u00f8st cellearrangement, sl\u00f8rede cellekonturer og \u00e5benlyse nekrotiske omr\u00e5der af tumorceller, hvilket indikerer membranbrud af tumorceller. Petroleums\u00e6terstedet i taro kunne fremkalde apoptose af tumorceller.<\/p>\n<p>Et stort antal unders\u00f8gelser har vist, at inflammation kan formidle en r\u00e6kke sygdomme, herunder hjerte-kar-sygdomme, kr\u00e6ft, diabetes, gigt, Alzheimers sygdom osv. Den vedvarende tilstedev\u00e6relse af \u00e5rsagsfaktorer kan f\u00f8re til inflammation, der ikke kan elimineres, og inflammation kan blive kronisk, hvilket resulterer i cellemutationer og spredning, som er mere befordrende for forekomsten og udviklingen af kr\u00e6ft. Tumornekrosefaktor (TNF) er et af de vigtige proinflammatoriske cytokiner. Mikromilj\u00f8et i forbindelse med brystkr\u00e6ft er pr\u00e6get af kronisk inflammation. TNF - \u03b1 kan fremme forekomsten og udviklingen af tumorer ved at stimulere \u00f8strogenmetabolismen i tumorceller og omgivende stromaceller og akkumulere \u00f8strogen. Unders\u00f8gelser har vist, at eksogen TNF - \u03b1 ikke kan fremkalde tumorcelleapoptose i MDAMB-468-, SK-BR3- og MDA-MB-231-celler, mens endogen TNF - \u03b1 har beskyttende antiapoptotisk aktivitet i HS578T-celler. De vigtigste kilder til det pro-inflammatoriske cytokin interleukin-1 \u03b2 (IL-1 \u03b2) omfatter myeloide celler som MDSC'er, makrofager og DC'er, som spiller en rolle i at fremme tumorv\u00e6kst eller forbedre anti-tumorimmunforsvaret i tumormikromilj\u00f8et. IL-1 \u03b2 har vist sig at fremme ophobningen af MDSC'er i umodne myeloide celler i tumormikromilj\u00f8et og derved fremme tumorprogression. I denne unders\u00f8gelse blev det fundet ved hj\u00e6lp af ELISA-kit-detektion, at sammenlignet med modelgruppen blev niveauerne af TNF - \u03b1 og IL-1 \u03b2 i serum i den positive l\u00e6gemiddelgruppe og grupperne behandlet med forskellige koncentrationer af taro reduceret, og h\u00f8jdosisgruppen havde de laveste niveauer. Derfor spekuleres der i, at petroleumsetherfraktionen af taro efter tumorinokulation i mus kan h\u00e6mme tumorudvikling ved at reducere proinflammatoriske cytokinniveauer. Konklusionen er, at petroleumsetherfraktionen af Taro acuminata har en betydelig effekt mod brystkr\u00e6ft in vivo.<\/p>\n<p>MAPK er en serinproteinkinase, der h\u00f8rer til den endogene apoptotiske vej. ERK, JNK og p38 er de tre vigtigste signalveje, der er opdaget hos pattedyr, med forskellige aktiveringstilstande. De deltager i signaleffekterne af forskellige v\u00e6kstfaktorer, cytokiner og hormonreceptorer efter aktivering og regulerer cellev\u00e6kst og -differentiering. I denne eksperimentelle unders\u00f8gelse var der ingen signifikant forskel i niveauerne af MAPKs signalvejsrelaterede proteiner, ERK, JNK, p38, p-JNK og p-p38 proteiner, og udtrykket af p-ERK-protein blev reduceret, hvilket tyder p\u00e5, at petroleumsetherdelen af Taro kan spille en antibrystkr\u00e6ftrolle ved at h\u00e6mme udtrykket af p-ERK\/ERK, hvilket er i overensstemmelse med resultaterne af tidligere unders\u00f8gelser in vitro og netv\u00e6rksfarmakologiforudsigelse af relaterede veje. Derudover kan EAC \u00f8ge udtrykket af Bax\/Bcl-2-protein og niveauet af apoptosegenet Bax\/Bcl-2 mRNA, hvilket tyder p\u00e5, at EAC spiller en rolle mod brystkr\u00e6ft ved at fremme apoptose af tumorceller.<br \/>\nFor at opsummere kan petroleumsetherfraktionen af taro h\u00e6mme tumorv\u00e6ksten hos 4T1-brystkr\u00e6ftb\u00e6rende mus. Dens effekt mod brystkr\u00e6ft er relateret til dens multikomponent- og multim\u00e5l-egenskaber. Dens mekanisme kan v\u00e6re relateret til nedregulering af p-ERK\/ERK-ekspression, stigningen i Bax\/Bcl-2-ekspression, stigningen i Bax\/Bcl-2 mRNA-niveau og fremme af tumorcelleapoptose. Denne unders\u00f8gelse giver en teoretisk reference til den kliniske anvendelse af Taro acuminata til behandling af brystkr\u00e6ft, men dens mere dybtg\u00e5ende materielle grundlag for effektivitet, m\u00e5l og mekanisme skal unders\u00f8ges yderligere.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology Globally, breast cancer accounts for 10% of the incidence rate of all cancers and 15% of female tumor related mortality. The latest Global Cancer Report 2020 published by the World Health Organization shows that 2.1 million new breast cancer cases [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/uplc-q-tof-ms-ms-and-network-pharmacology\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology Globally, breast cancer accounts for 10% of the incidence rate of all cancers and 15% of female tumor related mortality. The latest Global Cancer Report 2020 published by the World Health Organization shows that 2.1 million new breast cancer cases [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/da\/uplc-q-tof-ms-ms-and-network-pharmacology\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-03T14:20:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Skrevet af\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimeret l\u00e6setid\" \/>\n\t<meta name=\"twitter:data2\" content=\"12 minutter\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/\",\"url\":\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/\",\"name\":\"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png\",\"datePublished\":\"2024-08-03T14:20:47+00:00\",\"dateModified\":\"2024-08-03T14:20:47+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#breadcrumb\"},\"inLanguage\":\"da-DK\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"da-DK\",\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"da-DK\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"da-DK\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Udforskning af Taro acuminatas mekanisme mod brystkr\u00e6ft baseret p\u00e5 UPLC-Q-TOF-MS\/MS og netv\u00e6rksfarmakologi - China Chemical Manufacturer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/da\/uplc-q-tof-ms-ms-and-network-pharmacology\/","og_locale":"da_DK","og_type":"article","og_title":"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology - China Chemical Manufacturer","og_description":"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology Globally, breast cancer accounts for 10% of the incidence rate of all cancers and 15% of female tumor related mortality. The latest Global Cancer Report 2020 published by the World Health Organization shows that 2.1 million new breast cancer cases [&hellip;]","og_url":"https:\/\/longchangextracts.com\/da\/uplc-q-tof-ms-ms-and-network-pharmacology\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-03T14:20:47+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Skrevet af":"longcha9","Estimeret l\u00e6setid":"12 minutter"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/","url":"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/","name":"Udforskning af Taro acuminatas mekanisme mod brystkr\u00e6ft baseret p\u00e5 UPLC-Q-TOF-MS\/MS og netv\u00e6rksfarmakologi - China Chemical Manufacturer","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png","datePublished":"2024-08-03T14:20:47+00:00","dateModified":"2024-08-03T14:20:47+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#breadcrumb"},"inLanguage":"da-DK","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/"]}]},{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/uplc-q-tof-ms-ms-and-network-pharmacology\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"Producent af kemikalier i Kina","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"da-DK"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/posts\/3943"}],"collection":[{"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/comments?post=3943"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/posts\/3943\/revisions"}],"predecessor-version":[{"id":3972,"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/posts\/3943\/revisions\/3972"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/media?parent=3943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/categories?post=3943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/da\/wp-json\/wp\/v2\/tags?post=3943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}