{"id":3748,"date":"2024-08-03T07:42:11","date_gmt":"2024-08-03T07:42:11","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3748"},"modified":"2024-08-03T07:42:11","modified_gmt":"2024-08-03T07:42:11","slug":"trichothecium-roseum-diterpene","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/trichothecium-roseum-diterpene\/","title":{"rendered":"Diterpener med cytotoksisk aktivitet i fermenteringsprodukterne fra pink trichoderma"},"content":{"rendered":"

Diterpener med cytotoksisk aktivitet i fermenteringsprodukterne fra pink trichoderma
\nDen lyser\u00f8de trichothecium roseum, der tilh\u00f8rer Hyphomyceales-ordenen i Deuteromycotina-subfylum, blev opdaget og navngivet i 2008. Denne svamp er let at isolere fra r\u00e5dnende plantekroppe, jord og luft og er en udbredt plante- og gr\u00f8ntsagspatogen svamp over hele verden. Der har v\u00e6ret mange unders\u00f8gelser af metabolitterne fra pink trichoderma under laboratoriekulturforhold, med repr\u00e6sentative strukturer, herunder sesquiterpener, sesquiterpener, diterpener og cykliske peptider. Blandt dem er trichothecen den mest unders\u00f8gte. Tang et al. rapporterede, at monotrichothecen-forbindelser kan for\u00e5rsage forfald i \u00e6blekerner, mens monotrichothecen-toksiner h\u00e6mmer og forstyrrer protein- og nukleinsyresyntesen hos b\u00e5de mennesker og dyr, hvilket f\u00f8rer til immunsuppression af menneskers og dyrs sundhed. Indtagelse af f\u00f8devarer og produkter, der er forurenet med disse toksiner, kan for\u00e5rsage omfattende toksiske virkninger hos mennesker og dyr.<\/p>\n

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\nUd over toksinforbindelser er der ogs\u00e5 fundet forbindelser med cytotoksisk aktivitet i denne fermenteringsbouillon, s\u00e5som sesquiterpenforbindelsen cuspidatol, der findes i denne sl\u00e6gt, som viste st\u00e6rk immunosuppressiv aktivitet i MLR-analyser med en IC50-v\u00e6rdi p\u00e5 11 \u03bc g\/mL; Monotrichothecin A har en st\u00e6rk h\u00e6mmende effekt p\u00e5 v\u00e6ksten af HL-60-, SMMC-7721-, A549-, MCF-7- og SW480-celler med IC50-v\u00e6rdier p\u00e5 0,022, 0,020, 0,015, 0,006 og 0,006.022, 0,020, 0,015, 0,006 og 0.011 \u03bcmol\/L, som er sammenlignelige med den positive kontrol paclitaxel; diterpenforbindelsen rosonolacton har st\u00e6rke antiproliferative og proapoptotiske virkninger p\u00e5 humane livmoderhalskr\u00e6ft HeLa-celler; Roseocardin, en cyklisk esterpeptidforbindelse, har en positiv inotrop effekt p\u00e5 rotte-myokardiet; Den cykliske peptidforbindelse tricomide D udviste signifikant cytotoksicitet mod tre humane kr\u00e6ftcellelinjer (MCF-7, SW480, HL-6) med IC50-v\u00e6rdier p\u00e5 0.079, 0,107 og 0,149 \u03bcmol\/L, henholdsvis. Dette er den f\u00f8rste rapport om den cytotoksiske aktivitet af cykliske peptider. For at forts\u00e6tte med at s\u00f8ge efter nye forbindelser med cytotoksisk aktivitet isolerede og identificerede vores forskningsgruppe en stamme af pink trichothecus fra jorden, hvor vild Ganoderma lucidum vokser i Baise (hjembyen for Ganoderma lucidum). Vi brugte risdyrkningsmedium til at udvide fermenteringsprocessen for at opdage forbindelser med nye strukturer og god biologisk aktivitet og tilvejebringe l\u00e6gemiddelf\u00f8rende strukturer.<\/p>\n

I denne unders\u00f8gelse blev fem forbindelser isoleret og identificeret fra fermenteringsprodukterne fra T. roseum, som alle er diterpener. Blandt dem er forbindelse 1 en ny diterpenoidforbindelse. Dette resultat beriger mangfoldigheden af metabolitter produceret af pink trichoderma. Fem forbindelser viste varierende grader af h\u00e6mmende effekter p\u00e5 MCF-7-celler, hvor forbindelserne 1 og 5 udviste den bedste aktivitet. Det spekuleres i, at dette kan skyldes de lignende A- og B-ringstrukturer i forbindelse 1 og 5, mens forbindelse 5, selvom den er k\u00e6delignende, har en dominerende konformation med rumlig udvidelse svarende til forbindelse 1. Forbindelser med dette strukturelle tr\u00e6k viste bedre aktivitet i den aktivitetsforskningsmodel, der er valgt i denne artikel. Denne unders\u00f8gelse beriger mangfoldigheden af sekund\u00e6re metabolitstrukturer i Trichothecaum-svampe og giver en reference til screening af anti-tumoraktive forbindelser.<\/p>","protected":false},"excerpt":{"rendered":"

Diterpener med cytotoksisk aktivitet i fermenteringsprodukterne fra pink trichoderma Pink trichothecium roseum, der tilh\u00f8rer Hyphomyceales-ordenen i Deuteromycotina-subfylum, blev opdaget og navngivet i 2008. Denne svamp er let at isolere fra r\u00e5dnende plantekroppe, jord og luft og er en vidt udbredt plante- og gr\u00f8ntsagspatogen svamp over hele verden. Der har [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nDiterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/trichothecium-roseum-diterpene\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. This fungus is easily isolated from decaying plant bodies, soil, and air, and is a widely distributed plant and vegetable pathogenic fungus worldwide. 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