{"id":3264,"date":"2024-03-20T07:29:29","date_gmt":"2024-03-20T07:29:29","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=2980"},"modified":"2024-03-20T07:29:29","modified_gmt":"2024-03-20T07:29:29","slug":"what-is-the-effect-of-agitation-on-crystallization","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/da\/what-is-the-effect-of-agitation-on-crystallization\/","title":{"rendered":"Hvad er effekten af omr\u00f8ring p\u00e5 krystallisering?"},"content":{"rendered":"

Hvad er effekten af omr\u00f8ring p\u00e5 krystallisering?<\/strong><\/h1>\n

Den almindelige krystalliseringskedelomr\u00f8ring (Stirred tank crystallizer) er den aksiale padletype som vist i fig. a. Her designede forfatterne en ankerlignende skrabet v\u00e6gomr\u00f8ringspaddel (skrabet overfladekrystallisator) og valgte tre forskellige typer API'er for at unders\u00f8ge effekten af omr\u00f8ring p\u00e5 krystallisering.<\/p>\n

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Et omfattende kig p\u00e5 krystalliseringsteknikker, denne var en rigtig \u00f8jen\u00e5bner!
\nDen f\u00f8rste var ibuprofen (IBP), som blev krystalliseret ved at tils\u00e6tte en dr\u00e5be vand til en 25 \u00b0C opl\u00f8sning af IBP i DMSO. Ved krystallisering med ST aksial padleomr\u00f8ring ved 60 o\/min var omr\u00f8ringen ikke god, og efter 25 minutter var der en vandig fase i det \u00f8verste lag af DMSO, hvilket resulterede i et h\u00f8jt udbytte, da der blev udtaget pr\u00f8ver og analyseret efter 30 minutter. Ved fortsat omr\u00f8ring og pr\u00f8veudtagning resulterede krystallisering ved hj\u00e6lp af ST aksial flowomr\u00f8ring ved 200 o\/min og SS v\u00e6gskraberankeromr\u00f8ring ved 60 o\/min i lignende udbytter efter 30 minutter og 60 minutter.<\/p>\n

\"\"<\/p>\n

Hvordan anvender man en effektiv produktionsproces med kontinuerligt flow i biofarmaceutiske virksomheder? Med deling af cases!
\nDen h\u00e5rde skorpe p\u00e5 overfladen er relateret til arten af selve krystalliserings-API'en samt glatheden og h\u00e5rdheden af overfladen p\u00e5 omr\u00f8ringspadlen og krystalliseringskedlen. Med ST-paddeltypen i rustfrit st\u00e5l ved 200 o\/min (fig. c) var der mere alvorlig overfladeskorpe, men med SS-ankertypen ved 60 o\/min med PTFE var der mindre overfladeskorpe.<\/p>\n

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Diphenhydraminhydrochlorid (DPH) er en lamell\u00e6r krystal, der udf\u00e6ldes ved afk\u00f8ling fra 60 \u00b0C til 5 \u00b0C og derefter holdes. SS Anchor 60 rpm's krystalliseringskinetik svarer til ST 200 rpm's, og begge udf\u00e6lder hurtigere end ST Paddle 60 rpm.<\/p>\n

\"\"<\/p>\n

Forskelle og forbindelser mellem sm\u00e5 og opskalerede eksperimenter og pilotproduktion<\/p>\n

Der var flere klumper i krystallerne, der blev fremstillet ved hj\u00e6lp af ST-paddelomr\u00f8ring (fig. b, 60 rpm; c, 200 rpm) (fig. a).<\/p>\n

 <\/p>\n

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T\u00f8mningen var lettere med b\u00e5de SS Anchor 60rpm og ST Paddle 200rpm uden resterende klumpede faste stoffer, men ST 60rpm havde mere overfladeskorpedannelse og klumpede rester ved t\u00f8mning.<\/p>\n

\"\"<\/p>\n

For fluoxetinhydrochlorid (FLU) i n\u00e5leform, som ogs\u00e5 blev afk\u00f8let og dekrystalliseret, dekrystalliserede SS Anchor 60rpm betydeligt hurtigere end ST Paddle.<\/p>\n

\"\"<\/p>\n

Ved hj\u00e6lp af disse tre krystalliseringsbetingelser blev der opn\u00e5et lange, tynde, n\u00e5lelignende FLU-krystaller, hvor SS-ankertypen gav l\u00e6ngere krystaller (fig. a) end de andre (fig. a, ST, 60 o\/min; fig. c, ST, 200 o\/min). (T\u00f8r deling) Kontrolpunkter for industriel krystalliseringsproces og anvendelsestilf\u00e6lde<\/p>\n

\"\"<\/p>\n

Der var ingen udledningsproblemer ved brug af SS forankret 60 rpm (fig. a), men krystaller opn\u00e5et ved forskellige hastigheder ved hj\u00e6lp af ST var d\u00e5rligt mobile og kunne ikke h\u00e6ldes ud direkte, men f\u00f8rst efter at have opl\u00f8st opl\u00f8sningsmidlet (fig. b).<\/p>\n

\"\"<\/p>\n

Omfattende sammenligning:
\n1. ST Paddle Stirring 200 rpm fremmer krystalbrud, agglomerering og sekund\u00e6r nukleation, s\u00e5 krystalst\u00f8rrelsesfordelingen er bredere.
\n2. ST padleomr\u00f8ring 60 rpm, DPH-krystaller vokser til en vis st\u00f8rrelse og begynder at udf\u00e6ldes og agglomerere til bunden af kedlen. P\u00e5 grund af d\u00e5rlig omr\u00f8ring p\u00e5virkes krystalv\u00e6ksten af masseoverf\u00f8rsel, hvilket resulterer i langsommere krystaludf\u00e6ldning.
\n3. SS-ankeromr\u00f8ring 60 o\/min, fordi afstanden mellem ankeret og kedelv\u00e6ggen er mindre, den faste suspension er bedre, og CFD for v\u00e6skesimulering viser, at systemets gennemsnitlige forskydning er mindre. Mindre krystalbrud, som f.eks. krystallisering af FLU, end i andre omr\u00f8ringssystemer med fint brudte krystaller. Lav rotationshastighed og lav forskydning, s\u00e5 mindre interaktion mellem krystal og krystal og mellem krystal og kedelv\u00e6g, s\u00e5 mindre agglomerering.<\/p>","protected":false},"excerpt":{"rendered":"

What is the effect of agitation on crystallization? The common crystallization kettle stirring (Stirred tank crystallizer) is the axial paddle type as shown in Fig. a. Here the authors designed an anchor-like scraped-wall stirring paddle (scraped surface crystallizer) and selected three different types of APIs to study the effect of stirring on crystallization. A comprehensive […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nWhat is the effect of agitation on crystallization? - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/da\/what-is-the-effect-of-agitation-on-crystallization\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the effect of agitation on crystallization? - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"What is the effect of agitation on crystallization? The common crystallization kettle stirring (Stirred tank crystallizer) is the axial paddle type as shown in Fig. a. Here the authors designed an anchor-like scraped-wall stirring paddle (scraped surface crystallizer) and selected three different types of APIs to study the effect of stirring on crystallization. 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The common crystallization kettle stirring (Stirred tank crystallizer) is the axial paddle type as shown in Fig. a. Here the authors designed an anchor-like scraped-wall stirring paddle (scraped surface crystallizer) and selected three different types of APIs to study the effect of stirring on crystallization. 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