What is Calcium Dobesilate?

Calcium dobesilate is a synthetic vasoprotective agent that serves as the calcium salt of dobesilic acid. With the molecular formula C12H10CaO10S2 and a molecular weight of 418.4 g/mol, this compound is recognized for its remarkable ability to reduce capillary permeability in the human body. Originally developed and marketed under the trade name Doxium by the Swiss pharmaceutical company OM Pharma, calcium dobesilate has been widely prescribed across more than 60 countries in Europe, Latin America, Asia, and the Middle East for over three decades.

This vasoprotective agent works by strengthening blood vessel walls and improving microcirculation, making it a crucial medication for treating various vascular disorders. The compound is typically administered in capsule form, with the standard dosage being 500 mg of active ingredient per capsule.

What Are the Benefits?

Reduces Capillary Permeability

One of the primary benefits of calcium dobesilate is its ability to significantly reduce capillary permeability. This vasoprotective action helps prevent fluid leakage from blood vessels into surrounding tissues, which is particularly beneficial for patients suffering from conditions characterized by increased capillary fragility.

Improves Microcirculation

Calcium dobesilate enhances blood flow at the microcirculatory level, ensuring that oxygen and nutrients are efficiently delivered to tissues throughout the body. This improvement in microcirculation can have widespread benefits for overall vascular health.

Antioxidant Properties

Research has demonstrated that calcium dobesilate exhibits significant antioxidant activity. It helps reduce oxidative stress and inflammation, particularly in the retinas of diabetic patients. This antioxidant effect provides protection against cellular damage caused by free radicals.

Reduces Blood Viscosity

Studies have shown that calcium dobesilate can reduce both whole blood and plasma viscosity by lowering PAI-1 (plasminogen activator inhibitor-1) expression. This blood-thinning effect improves overall circulation and reduces the risk of thrombotic events.

Protects Diabetic Complications

For patients with diabetic nephropathy, calcium dobesilate has been shown to reduce urinary albumin excretion rate (UAER), a critical marker of kidney damage in diabetes. This renoprotective effect makes it a valuable therapeutic option for diabetic patients.

What Are the Uses?

Chronic Venous Disease

Calcium dobesilate is primarily prescribed for the treatment of chronic venous disease (CVD). It helps alleviate symptoms such as leg heaviness, swelling, and varicose veins by improving venous tone and reducing capillary leakage.

Diabetic Retinopathy

Another major application of calcium dobesilate is in the management of diabetic retinopathy. The compound helps protect the retinal vasculature from diabetic damage by reducing oxidative stress and inflammation in the retina, potentially slowing the progression of this serious complication.

Hemorrhoids

The vasoprotective properties of calcium dobesilate make it effective in treating hemorrhoids. By strengthening blood vessel walls and reducing capillary permeability, it helps alleviate hemorrhoid symptoms and promotes healing.

Diabetic Nephropathy

In patients with diabetic nephropathy, calcium dobesilate has demonstrated the ability to reduce proteinuria (excess protein in urine) by lowering UAER levels, thereby providing renal protection.

Safety and Side Effects

Calcium dobesilate is generally well-tolerated when taken as prescribed. However, as with any medication, some patients may experience side effects. Common adverse reactions include:

• Gastrointestinal disturbances (nausea, vomiting, diarrhea)
• Neurological symptoms (headache, vertigo)
• Skin reactions (rash)
• General symptoms (fever, chills)

In rare cases, patients may experience irregular heartbeats. It is important to consult a healthcare professional before starting calcium dobesilate therapy, especially for patients with pre-existing medical conditions or those taking other medications.

Contraindications and Precautions

Calcium dobesilate should not be used by individuals with known hypersensitivity to the compound or any of its components. Pregnant and breastfeeding women should only use this medication under strict medical supervision.

Chemical Specifications

Property	Værdi
CAS-nummer	20123-80-2
Molekylær formel	C12H10CaO10S2
Molekylvægt	418.4 g/mol
UNII	5921X1560Q
InChI Key	QGNBTYAQAPLTMX-UHFFFAOYSA-L
Udseende	Hvidt til off-white krystallinsk pulver

Frequently Asked Questions

Q: What is calcium dobesilate used for?

A: Calcium dobesilate is primarily used to treat chronic venous disease, diabetic retinopathy, hemorrhoids, and diabetic nephropathy. It works by reducing capillary permeability and improving microcirculation.

Q: Is calcium dobesilate safe for long-term use?

A: Clinical studies have shown that calcium dobesilate has a favorable safety profile for long-term use. However, patients should undergo regular monitoring and consult their healthcare provider for appropriate duration of treatment.

Q: How quickly does calcium dobesilate work?

A: The onset of action varies depending on the condition being treated. Some patients may experience improvement in symptoms within 2-4 weeks of consistent treatment.

Q: Can calcium dobesilate be taken with other medications?

A: Patients should inform their healthcare provider about all medications they are taking before starting calcium dobesilate. While no significant drug interactions have been reported, it is always best to consult a physician.

Why Choose Our Calcium Dobesilate?

As a leading manufacturer and supplier of pharmaceutical intermediates, we provide high-quality calcium dobesilate that meets international quality standards. Our product is manufactured under strict quality control conditions, ensuring purity and consistency in every batch.

We offer competitive pricing, reliable delivery, and technical support for customers worldwide. Contact us today to learn more about our calcium dobesilate products and how we can support your pharmaceutical or research needs.

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