What Is Carbasalate Calcium?

Carbasalate calcium (CAS 5749-67-7) is a non-steroidal anti-inflammatory drug (NSAID) used as an analgesic, antipyretic and anti-inflammatory agent. It is a calcium salt complex of acetylsalicylic acid (aspirin) and urea. By combining aspirin with calcium and urea, carbasalate calcium is designed to improve gastric tolerability while maintaining the well-known efficacy of salicylates for pain and fever relief.

As an active pharmaceutical ingredient (API), carbasalate calcium is used in oral solid dosage forms such as powders, granules and effervescent preparations, often for over-the-counter or prescription products depending on the target market and national regulations.

What Are the Benefits of Carbasalate Calcium?

Effective Analgesic (Pain Relief)

Carbasalate calcium provides rapid and reliable relief of mild to moderate pain, including headache, toothache, musculoskeletal pain, menstrual pain and pain associated with colds or flu-like infections. As a salicylate derivative, it shares the well-characterized analgesic profile of aspirin while offering improved gastric tolerability in many patients.

Antipyretic (Fever-Reducing) Action

Like aspirin, carbasalate calcium has a strong antipyretic effect. It helps reduce elevated body temperature by acting on the hypothalamic thermoregulatory center and by inhibiting prostaglandin synthesis. It is commonly used in formulations intended to relieve fever associated with respiratory infections and other acute illnesses.

Anti‑Inflammatory Properties

Carbasalate calcium inhibits cyclooxygenase (COX) and decreases the synthesis of pro-inflammatory prostaglandins. This mechanism underlies its anti-inflammatory effect, making it suitable for symptomatic relief in conditions with mild inflammatory components, such as joint pain, soft tissue pain and post-traumatic discomfort.

Improved Gastric Tolerability Compared with Aspirin

The complexation of acetylsalicylic acid with calcium and urea can help reduce direct gastric irritation compared with plain aspirin in some patients. Formulators often select carbasalate calcium when they want to maintain the clinical benefits of aspirin but aim for better gastrointestinal tolerability profiles in their finished products.

What Are the Uses of Carbasalate Calcium?

Carbasalate calcium is mainly used as an API in oral preparations for pain and fever management. Typical application areas include:

• Relief of mild to moderate pain (e.g. headache, toothache, neuralgia, musculoskeletal pain)
• Symptomatic treatment of fever and discomfort in common cold or flu-like illnesses
• Short-term relief of joint and soft tissue pain of inflammatory origin
• Combination products with other APIs (such as decongestants or antitussives) in cold and flu formulations, depending on local regulations

Formulators can use carbasalate calcium in powders, sachets, effervescent tablets, granules and other oral dosage forms designed for rapid onset of action and good patient compliance.

Mechanism of Action

Carbasalate calcium acts primarily through its salicylate component. After administration, the complex releases acetylsalicylic acid, which:

• Irreversibly inhibits cyclooxygenase (COX) enzymes
• Reduces the formation of prostaglandins and thromboxanes
• Lowers peripheral sensitization of nociceptors and central pain perception
• Decreases prostaglandin-mediated elevation of the hypothalamic temperature set point

This combined action provides analgesic, antipyretic and mild anti-inflammatory effects. The calcium and urea components contribute to solubility and tolerability characteristics of the salt complex.

Safety and Side Effects

As with all salicylates and NSAIDs, the use of carbasalate calcium must be guided by appropriate medical and regulatory standards. Key safety considerations include:

• Gastrointestinal effects: Although carbasalate calcium is often better tolerated than plain aspirin, high doses or prolonged use can still cause gastrointestinal discomfort, dyspepsia, nausea or, rarely, ulceration and bleeding, especially in susceptible patients.
• Bleeding risk: Salicylates inhibit platelet aggregation and may increase the risk of bleeding. Caution is required in patients taking anticoagulants or other drugs that affect hemostasis.
• Hypersensitivity: Individuals with known hypersensitivity to salicylates, aspirin-induced asthma or NSAID allergy should not use carbasalate calcium.
• Use in children: As with aspirin, use in children and adolescents with viral infections should follow local guidelines due to the potential association with Reye’s syndrome.
• Renal and hepatic function: High doses or long-term use may affect renal or hepatic function, particularly in patients with pre-existing impairment.

Typical adverse reactions are similar to those of aspirin and include mild gastrointestinal symptoms, dizziness or allergic skin reactions in susceptible individuals. Formulation, dose and treatment duration should be designed carefully to balance efficacy and safety.

Important: Carbasalate calcium is an active pharmaceutical ingredient. Finished dosage forms and clinical use must comply with local regulations and should be supervised by qualified healthcare professionals.

Chemical Specifications of Carbasalate Calcium (CAS 5749-67-7)

• Product Name: Carbasalate Calcium
• CAS Number: 5749-67-7
• Category: Active Pharmaceutical Ingredient (API)
• General Description: Calcium salt complex of acetylsalicylic acid and urea
• Appearance: White or almost white crystalline powder
• Assay: Typically ≥ 99% (on dry basis, HPLC or titration, according to internal specification)
• Solubility: Freely soluble or soluble in water; solubility may be pH-dependent
• Loss on Drying: Within controlled limits according to COA
• Related Substances: Impurities and degradants controlled within tight limits suitable for pharmaceutical use
• Heavy Metals / Residual Solvents: Compliant with relevant pharmacopeial or ICH guidelines

Detailed specifications (including particle size distribution, microbiological limits and stability data) can be customized or aligned with the requirements of your target market and formulation.

Frequently Asked Questions

Is carbasalate calcium the same as aspirin?
No. Carbasalate calcium is a salt complex of acetylsalicylic acid with calcium and urea. It acts through the same basic salicylate mechanisms as aspirin but has different physicochemical and tolerability characteristics.

What dosage forms typically use carbasalate calcium?
It is commonly used in powders, sachets, effervescent tablets and other oral solid dosage forms intended for rapid onset of analgesic and antipyretic action.

Can carbasalate calcium be combined with other APIs?
Yes. It is often formulated together with other agents such as decongestants, antihistamines or vitamin C in cold and flu preparations, provided such combinations comply with the regulatory framework of the target market.

How should carbasalate calcium be stored?
Store in a tightly closed container, in a cool and dry place, protected from moisture and direct sunlight. Follow the storage conditions and shelf life indicated on the COA and stability documents.

Why Choose Our Carbasalate Calcium?

We supply high-quality carbasalate calcium (CAS 5749-67-7) designed for pharmaceutical applications:

• High and consistent purity with strict control of impurities and trace contaminants
• Pharmaceutical-grade production under robust quality systems and full batch traceability
• Flexible packaging options from pilot-scale to commercial quantities
• Technical support including COA, MSDS and supporting data for formulation and registration
• Reliable supply chain to support long-term projects and multi-market registrations

Related Products

• Acetylsalicylic Acid (Aspirin)
• Calcium Acetate
• Calcium Orotate
• Other analgesic and antipyretic APIs