What are pressed candy and functional health food tablets?

Tablets are solid preparations with dense structure formed by the action of tablet press on one or several kinds of powders. With different shapes, beautiful appearance, accurate dosage, taking aspect, multiple routes of administration, which can meet different clinical needs, it is one of the most important dosage forms in modern solid preparations.
The compression characteristics of pressed tablet materials are usually a combination of multiple compression and deformation mechanisms and multiple powder chemical properties. The compression characteristics and fluidity of tabletting materials directly affect their adaptability to high-speed tabletting in production, and the ideal tabletting materials should have excellent fluidity and compressibility.
Types of tablets include: oral tablets, chewable tablets, effervescent tablets, oral tablets, orally disintegrating tablets; general raw materials and auxiliary materials include: active ingredients, fillers, lubricants, sweeteners, colors, flavors, stabilizers, effervescent agents, disintegrating agents.
Pressure tablet candy is often easy to appear the problem of flavor
1, the selection principle of flavor – Recommendation: the use of oil-soluble liquid flavor, flavor presentation is better than powder flavor, can also use powder flavor – Recommendation: IFF, Chihuadong, Fenmei – prohibited: water-soluble flavor
2、Frequently Problems- With water-soluble flavors, the phenomenon of caking and hardening occurs. The taste is a little rough and the flavor is not natural. – Worry about the oil-soluble liquid flavor can not be mixed, do not dare to use, so the taste can not reach the state of competitors.
Pressure tablet candy often prone to problems lubricants (magnesium stearate, etc.)
1, the use of lubricants principles – must: magnesium stearate and other lubricants need to be added now; – must: magnesium stearate needs to be added in the final stage of mixing; – Recommendations: the typical amount of magnesium stearate added 0.8%, less than 0.5% or too much lubrication effect is reduced; – Recommendation: in some special tablets (solid beverage standard effervescent tablets, need to consider dissolvable lubricants sucrose esters, etc.)
2. Frequently asked questions – Do not allow the material mixed with magnesium stearate to be pressed overnight or for a longer period of time, as this will greatly affect the compressibility. – Do not add magnesium stearate, or add more than 2% magnesium stearate.
Tablet confectionery is often prone to the problem of tabletting environment
1、Relative humidity – For sorbitol, xylitol and other materials that are easy to absorb moisture, the humidity of the experimental and production environment should be controlled within 40%, while other materials such as maltitol can be relaxed to 50%;
2、Environmental temperature-The temperature of tablet pressing environment should be controlled within 25 degrees.
3, how to improve the environmental humidity and temperature – dehumidification equipment (independent industrial dehumidifier, preferably equipped with tabletting workshop) – air-conditioning system – select the dry weather and lower temperature season staggered production – the use of moisture-resistant materials
Tablet confectionery often prone to the problem of color pigmentation
Aluminum precipitate is recommended – Aluminum precipitate has the characteristic of uniform coloring and the overall color of tablets is transparent. It is more stable relative to environmental temperature, humidity, oxygen and other factors. – Suggested source: Shanghai Dyestuff Research Institute Co.
2、Frequently Problems- Adopting some other types of powder pigment, there is poor mixing effect, spots, uneven coloring; – VC and other substances that are easy to oxidize and change color, originally no color, the color is abnormal after preservation or accelerated experiments, and it is necessary to add some approximate color to cover up – Some materials itself The color of some materials itself is very dark, easy to cause significant spots, we generally recommend the use of finer maltitol or the use of further granulation process.
Pressure tablet candy often prone to bend the formula design
1, the selection of excipients to examine the factors – hygroscopicity → consider moisture absorption materials – oxidation resistance, heat sensitivity, light sensitivity → consider coating, reducing agent and other measures – granularity, fluidity → mixing difficulty → each piece of the dose accuracy, coloring uniformity, taste, tablet weight stability – Effective dosage of functional materials → design of tablet weight, frequency of taking – Taste, flavor, color of functional materials → flavor, acid, pigment, coating, etc.
2、Frequently asked questions for some of the finest granularity of the material 200-400 mesh, usually poor compression, the proportion of auxiliary additives need to be increased;
– Good flowability is the key to reduce the above problems —-Angle of repose —-Hausner Ratio- More advanced instruments have powder flow characteristics tester