# Anthralin (CAS 1143-38-0): Complete Guide to This Proven Psoriasis Treatment

## What is Anthralin?

Anthralin, also known as dithranol or 1,8-dihydroxy-9-anthrone, is a synthetic compound that has been used for over a century to treat psoriasis. Originally derived from chrysarobin, which was obtained from the araroba tree in Brazil, anthralin remains a trusted topical treatment for stable plaque psoriasis. Its chemical formula is C₁₄H₁₀O₃, and it works by targeting the abnormal skin cell growth that characterizes psoriasis.

## What Are the Benefits?

### Effective Psoriasis Treatment
Anthralin has long been established as an effective topical treatment for stable psoriasis vulgaris. It works by blocking keratinocyte proliferation and T-cell activation, two key factors in psoriasis development. Clinical studies have shown that anthralin can significantly reduce psoriasis symptoms, including scaling, redness, and thickness of plaques.

### Anti-inflammatory Properties
The compound helps reduce inflammation in affected skin areas. It works by decreasing the elevated levels of cyclic guanosine monophosphate (cGMP) that occurs in psoriasis, thereby helping to normalize skin cell growth.

### Antioxidant Effects
Anthralin also acts as an antioxidant, providing additional benefits for skin health. This antioxidant property helps protect skin cells from oxidative damage.

### Proven Track Record
Since its first use in 1916, anthralin has been successfully used as an intermittent topical treatment for psoriasis. Its long history of effectiveness makes it a reliable choice for patients with chronic psoriasis.

## What Are the Uses?

### Primary Use: Psoriasis Treatment
Anthralin is primarily used to treat stable plaque psoriasis, one of the most common forms of psoriasis. It is particularly effective for:
– Plaque psoriasis
– Scalp psoriasis
– Chronic, well-established psoriatic lesions

### Application Methods
– **Short Contact Therapy**: Anthralin can be effective even when left on the skin for only 10 minutes. This “short contact” method allows stronger concentrations with less burning and staining.
– **Ointment Formulations**: Available in various concentrations (typically 0.1% to 2%)
– **Combination Therapy**: Often used alongside other treatments like phototherapy for enhanced results

### Mechanism of Action
Anthralin works by:
1. Inhibiting keratinocyte hyperproliferation
2. Reducing granulocyte function
3. Exerting immunosuppressive effects
4. Normalizing skin cell turnover

## Safety and Side Effects

### Common Side Effects
– Skin irritation, burning, or stinging
– Temporary staining of skin and clothing
– Redness in treated areas

### Precautions
– Avoid contact with eyes, mouth, and mucous membranes
– Do not use on inflamed or broken skin
– Start with lower concentrations to assess tolerance
– Wash hands thoroughly after application

### Contraindications
– Hypersensitivity to anthralin or any of its components
– Acute or actively inflamed psoriasis
– Extensive body surface area involvement (without medical supervision)

## Chemical Specifications

| Property | Value |
|———-|——-|
| CAS Number | 1143-38-0 |
| Molecular Formula | C₁₄H₁₀O₃ |
| Molecular Weight | 226.23 g/mol |
| Appearance | Brownish-yellow to orange-brown crystalline powder |
| Solubility | Slightly soluble in water; soluble in organic solvents |

## Frequently Asked Questions

### How long does it take for anthralin to work?
Anthralin typically shows improvement within 2-4 weeks of consistent use. Full results may take longer depending on the severity of the condition.

### Can anthralin be used with other psoriasis treatments?
Yes, anthralin is often combined with other treatments such as topical corticosteroids, vitamin D analogues, and phototherapy. Always consult a healthcare provider before combining treatments.

### Does anthralin stain clothing?
Yes, anthralin can stain skin and clothing. It is recommended to apply the treatment at night and wear old clothing or use protective coverings.

### Is anthralin safe for long-term use?
Anthralin can be used long-term under medical supervision. However, many patients use it intermittently to minimize side effects while maintaining results.

## Why Choose Our Anthralin?

– **High Purity**: Our Anthralin meets pharmaceutical grade standards
– **Consistent Quality**: Batch-to-batch consistency for reliable treatment outcomes
– **Competitive Pricing**: Cost-effective solution for psoriasis management
– **Technical Support**: Our team provides technical assistance and product documentation
– **Global Shipping**: Reliable delivery worldwide

## Related Products

If you’re interested in Anthralin, you may also find these products useful:

– [Azelaic Acid (CAS 123-99-9)](https://longchangextracts.com/product/azelaic-acid/) – Another skin treatment compound
– [Alpha Lipoic Acid (CAS 1077-28-7)](https://longchangextracts.com/product/alpha-lipoic-acid/) – Powerful antioxidant
– [Apigenin (CAS 520-36-5)](https://longchangextracts.com/product/apigenin/) – Natural flavonoid with anti-inflammatory properties

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*This article is for informational purposes only. Always consult a healthcare professional before starting any new treatment.*