What is Adefovir?

Adefovir, with the CAS number 106941-25-7, is a potent antiviral medication classified as an acyclic phosphonate nucleotide analog of dAMP. It is commercially known by its trade names Preveon and Hepsera. This compound is primarily used for the treatment of chronic hepatitis B virus (HBV) infections.

Chemical Properties

• Molecular Formula: C₈H₁₂N₅O₄P
• Molecular Weight: 273.19 g/mol
• CAS Number: 106941-25-7
• Synonyms: GS-0393, GS-393, PMEA, 9-(2-phosphonylmethoxyethyl)adenine
• Appearance: White to off-white powder
• Purity: ≥98% (HPLC)

Mechanism of Action

Adefovir works as a DNA polymerase inhibitor. It exerts its antiviral activity by:

1. Inhibiting reverse transcriptase – Blocks HIV-1 replication
2. Inhibiting polymerase activity – Prevents HBV DNA replication
3. Chain termination – Incorporates into viral DNA, causing premature termination

The compound is converted to its active diphosphate form inside cells, which then competitively inhibits viral DNA polymerase.

Applications and Uses

Pharmaceutical Applications

• Hepatitis B Treatment: Primary indication for chronic HBV infection
• HIV Therapy: Shows activity against HIV-1
• Antiviral Research: Widely used in antiviral drug development

Research Applications

• Laboratory research on nucleotide analogs
• Development of new antiviral therapies
• Studies on viral resistance mechanisms

Benefits

1. Broad-spectrum antiviral activity – Effective against multiple viruses including HBV and herpesviruses
2. Oral bioavailability – Can be administered in prodrug form (adefovir dipivoxil)
3. Well-established safety profile – Approved for clinical use
4. Resistance management – Used in treatment-experienced patients

Safety Information

Handling Precautions

• Handle with care in a controlled environment
• Use appropriate personal protective equipment (PPE)
• Store at recommended conditions

Storage

• Store in a cool, dry place
• Keep away from direct sunlight
• Maintain proper ventilation

Regulatory Status

Adefovir is a prescription medication and must be used under medical supervision. It is approved by regulatory agencies including FDA and EMA for the treatment of chronic hepatitis B.

Why Choose Our Adefovir?

• High purity (≥98% HPLC)
• Consistent quality with batch-to-batch reliability
• Competitive pricing for research and pharmaceutical applications
• Technical support available for handling and applications
• Reliable supply chain for bulk orders

Frequently Asked Questions

Q: What is Adefovir used for?

A: Adefovir is primarily used to treat chronic hepatitis B virus (HBV) infections. It may also have applications in HIV research.

Q: How does Adefovir work?

A: Adefovir inhibits viral DNA polymerase and reverse transcriptase enzymes, preventing viral replication.

Q: Is Adefovir the same as Tenofovir?

A: No, they are different but related compounds. Both are nucleotide analogs used as antivirals, but Tenofovir is more commonly used today due to better safety profile.

Q: What is the CAS number for Adefovir?

A: The CAS number for Adefovir is 106941-25-7.

This article is for informational purposes only. For medical use, please consult healthcare professionals.