Alpha Lipoic Acid (CAS 1077-28-7), also known as α-Lipoic Acid, ALA, or Thioctic Acid, is a naturally occurring compound that has gained significant attention in the health and pharmaceutical industries. This powerful antioxidant is unique because it is both water-soluble and fat-soluble, allowing it to work in every cell of the body. Originally discovered in the 1950s, Alpha Lipoic Acid has since become one of the most studied supplements for its potential health benefits, particularly in relation to diabetes, aging, and oxidative stress.
With a molecular formula of C8H14O2S2 and a molecular weight of 206.33 g/mol, this compound appears as a yellow crystalline powder. It is classified as a Food Additive and is widely used in dietary supplements, pharmaceutical formulations, and as an intermediate in chemical synthesis. Our company supplies high-purity Alpha Lipoic Acid (CAS 1077-28-7) to customers worldwide, meeting the highest quality standards for pharmaceutical and nutritional applications.
What Are the Benefits?
Powerful Antioxidant Properties
Alpha Lipoic Acid is often called the “universal antioxidant” because of its unique ability to dissolve in both water and fat. This means it can protect cells throughout the body, including in the brain and nervous system. Unlike many other antioxidants, Alpha Lipoic Acid can regenerate itself and help restore other antioxidants like Vitamin C, Vitamin E, and glutathione to their active forms.
Supports Blood Sugar Control
One of the most well-documented benefits of Alpha Lipoic Acid is its ability to improve insulin sensitivity and help manage blood sugar levels. Research published in scientific journals shows that ALA can enhance glucose uptake in cells, making it easier for the body to use insulin effectively. This makes it particularly valuable for individuals with type 2 diabetes or those at risk of developing the condition.
Diabetic Neuropathy Relief
Alpha Lipoic Acid has been extensively studied for its effects on diabetic neuropathy, a common complication of diabetes that causes nerve damage and pain. Clinical trials have shown that supplementation with ALA can significantly reduce symptoms of diabetic neuropathy, including pain, burning, and numbness, particularly in the hands and feet. The European Association for the Study of Diabetes has recognized Alpha Lipoic Acid as a treatment option for this condition.
Anti-Aging and Cellular Health
As we age, our body’s natural antioxidant defenses decline, leading to increased oxidative stress and cellular damage. Alpha Lipoic Acid helps combat this process by neutralizing free radicals and supporting mitochondrial function—the powerhouses of our cells. Some research suggests that ALA may help slow down age-related cognitive decline and support overall vitality.
Supports Heart Health
Alpha Lipoic Acid may contribute to cardiovascular health through multiple mechanisms. It helps reduce inflammation, improves lipid profiles, and enhances endothelial function—the lining of blood vessels. Some studies indicate that ALA can help lower LDL (“bad”) cholesterol and triglycerides while increasing HDL (“good”) cholesterol levels.
What Are the Uses?
Dietary Supplements
The primary commercial use of Alpha Lipoic Acid is in dietary supplements. It is commonly found in standalone supplements or combined with other antioxidants and nutrients. Supplements are marketed for various purposes including blood sugar support, antioxidant protection, anti-aging, and general wellness. Typical doses in supplements range from 100 mg to 600 mg per day.
Pharmaceutical Applications
In the pharmaceutical industry, Alpha Lipoic Acid is used in formulations for treating diabetic neuropathy and other conditions. It is available by prescription in some countries as an intravenous or oral treatment. Pharmaceutical-grade ALA is also used in research and clinical trials to investigate its potential therapeutic applications.
Food Additive
Alpha Lipoic Acid is approved as a food additive in many countries, used for its antioxidant properties to preserve food quality and extend shelf life. It is also incorporated into functional foods and beverages marketed for their health benefits.
Cosmetic and Skincare Products
The antioxidant properties of Alpha Lipoic Acid make it a valuable ingredient in cosmetic and skincare formulations. It is believed to help protect skin from oxidative damage caused by UV radiation and environmental pollutants, potentially reducing signs of aging and improving skin texture.
Safety and Side Effects
Generally Recognized as Safe
Alpha Lipoic Acid is generally recognized as safe (GRAS) by regulatory authorities when used at recommended levels. Toxicity studies have shown that ALA has low acute toxicity, with LD50 values exceeding 2000 mg/kg in animal studies. However, as with any supplement, it should be used according to recommended guidelines.
Common Side Effects
When taken at higher doses, Alpha Lipoic Acid may cause some side effects, including:
- Stomach upset or nausea
- Diarrhea
- Skin rash (in rare cases)
- Headache
Important Precautions
- Diabetes Medications: Alpha Lipoic Acid may enhance the blood sugar-lowering effects of diabetes medications. Individuals taking insulin or other diabetes drugs should monitor their blood sugar closely and consult a healthcare provider.
- Pregnancy and Breastfeeding: The safety of ALA during pregnancy and breastfeeding is not well established. Consult a doctor before use.
- Thyroid Medications: ALA may affect thyroid hormone levels. Those taking thyroid medications should speak with their healthcare provider.
- Surgery: Due to its effects on blood sugar, ALA should be discontinued at least two weeks before scheduled surgery.
Recommended Dosage
There is no official recommended daily allowance for Alpha Lipoic Acid. However, clinical studies typically use doses ranging from 600 mg to 1,800 mg per day for treating diabetic neuropathy. For general antioxidant support, lower doses of 100-300 mg daily are commonly used. It is recommended to take ALA 30-60 minutes before meals for optimal absorption.
Chemical Specifications
| Property | Value |
| CAS Number | 1077-28-7 |
| Molecular Formula | C8H14O2S2 |
| Molecular Weight | 206.33 g/mol |
| Synonyms | α-Lipoic Acid, ALA, Thioctic Acid, DL-6,8-Thioctic Acid |
| Appearance | Yellow crystalline powder |
| Purity | ≥98% |
| Solubility | Soluble in water and organic solvents |
| Classification | Food Additive |
Frequently Asked Questions
What is the difference between R-Lipoic Acid and Alpha Lipoic Acid?
Alpha Lipoic Acid exists in two forms: R-lipoic acid and S-lipoic acid. The R-form is the biologically active form that occurs naturally in the body. Standard ALA supplements contain a 50/50 mixture of both forms (racemic). Some researchers believe R-lipoic acid may be more effective, though scientific evidence is still inconclusive.
Can Alpha Lipoic Acid help with weight loss?
Some studies suggest that Alpha Lipoic Acid may support weight loss efforts by improving insulin sensitivity and potentially reducing appetite. However, the effects are modest, and ALA should not be considered a weight loss miracle. It works best when combined with a healthy diet and regular exercise.
How long does it take to see results?
The time to experience benefits varies depending on the individual and the intended use. For blood sugar support, some people may notice effects within a few weeks. For diabetic neuropathy symptoms, clinical improvements are typically observed after 3-5 weeks of consistent supplementation.
Can I take Alpha Lipoic Acid with other supplements?
Alpha Lipoic Acid can generally be taken with other supplements. It is often combined with Vitamin B-complex (especially B1, B6, and B12) for nerve health support. However, it’s advisable to space out the intake of ALA and mineral supplements, as ALA may affect mineral absorption.
Is Alpha Lipoic Acid the same as alpha-linolenic acid?
No, they are different compounds. Alpha Lipoic Acid (ALA/Thioctic Acid) is a sulfur-containing compound with antioxidant properties. Alpha-linolenic acid (also ALA) is an omega-3 fatty acid found in plant sources like flaxseeds and walnuts. The abbreviations can be confusing, but these are distinct substances.
Why Choose Our Alpha Lipoic Acid?
When sourcing Alpha Lipoic Acid (CAS 1077-28-7) for your pharmaceutical, supplement, or food applications, our company offers:
- High Purity: ≥98% purity guaranteed, meeting pharmaceutical and food-grade standards
- Quality Assurance: All products come with comprehensive Certificates of Analysis (CoA)
- Consistent Supply: Reliable production capacity for bulk orders
- Technical Support: Our team provides technical documentation and customization options
- Competitive Pricing: Factory-direct pricing for quantity orders
- Global Shipping: Efficient logistics to customers worldwide
We supply Alpha Lipoic Acid (CAS 1077-28-7) to pharmaceutical companies, supplement manufacturers, food producers, and research institutions globally. Contact us for quotes on bulk orders, custom specifications, and packaging options tailored to your needs.
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