Carbocisteine (CAS 638-23-3): Complete Guide to This Popular Mucolytic Agent
What is Carbocisteine?
Carbocisteine (CAS 638-23-3), also known as carbocysteine, is a mucolytic agent that belongs to the class of expectorants. It is chemically designated as S-(carboxymethyl)-cysteine and is derived from the amino acid cysteine. This compound is widely used in pharmaceutical formulations to help relieve respiratory conditions associated with excessive mucus production.
Carbocisteine works by reducing the viscosity of sputum (mucus), making it easier for patients to cough up and clear from their airways. Unlike cough suppressants, carbocisteine does not inhibit the cough reflex; instead, it facilitates expectoration by thinning the mucus.
What Are the Benefits?
Respiratory Health Benefits
COPD Management: Carbocisteine is particularly beneficial for patients with Chronic Obstructive Pulmonary Disease (COPD). It helps reduce mucus hypersecretion, which is a common symptom of COPD, allowing for easier breathing and reduced respiratory discomfort.
Bronchiectasis Relief: Patients with bronchiectasis, a condition characterized by damaged airways, benefit from carbocisteine’s mucolytic properties. By thinning the thick mucus that accumulates in the bronchi, it helps reduce infections and improves lung function.
Chronic Bronchitis Treatment: Carbocisteine is effective in managing chronic bronchitis by reducing mucus viscosity. This makes it easier for patients to clear their airways, decreasing coughing frequency and severity.
Cystic Fibrosis Support: While primarily used for adults, carbocisteine may provide symptomatic relief for some cystic fibrosis patients by helping clear the thick, sticky mucus characteristic of this genetic disorder.
Additional Advantages
- Non-drowsy formula: Unlike many cough medications, carbocisteine does not cause drowsiness
- Long-term use capability: Can be used for extended periods under medical supervision
- Available in multiple forms: Syrups, tablets, and capsules for patient preference
- Well-established safety profile: Used globally for decades with proven efficacy
What Are the Uses?
Primary Medical Applications
- Treatment of COPD: Reduces exacerbations and improves quality of life
- Bronchiectasis management: Helps clear accumulated mucus
- Chronic bronchitis: Thins mucus for easier expectoration
- Post-operative respiratory care: Assists in clearing airway secretions
Cosmetic and Skincare Applications
Interestingly, carbocisteine has found application in dermatology. It can help control sebum production in skin care products, making it useful in formulations targeting oily skin conditions.
Veterinary Medicine
Carbocisteine is also used in veterinary medicine to treat respiratory conditions in animals, particularly in horses and small pets suffering from respiratory tract infections.
Safety and Side Effects
Common Side Effects
Most side effects are mild and include:
- Gastrointestinal discomfort
- Nausea
- Diarrhea
- Skin rash (rare)
Important Considerations
- Not a cough suppressant: It may actually increase coughing as the body works to expel loosened mucus
- Pregnancy and breastfeeding: Consult a doctor before use
- Drug interactions: Inform your healthcare provider of all medications being taken
- Under medical supervision: Should be used as prescribed by a healthcare professional
Contraindications
- Known hypersensitivity to carbocisteine or cysteine derivatives
- Active peptic ulcer disease
- Severe hepatic or renal impairment (use with caution)
Chemical Specifications
| Property | Value |
| CAS Number | 638-23-3 |
| Molecular Formula | C5H9NO4S |
| Molecular Weight | 179.19 g/mol |
| Appearance | White crystalline powder |
| Melting Point | 205-207°C (decomposes) |
| Solubility | Soluble in water |
| Classification | Mucolytic / Expectorant |
Frequently Asked Questions
How long does it take for carbocisteine to work?
Patients typically notice improvement within 1-2 weeks of regular use. However, full benefits may take up to 4-6 weeks of continuous treatment.
Can I take carbocisteine with other cough medications?
It’s important to consult your doctor or pharmacist. Generally, it can be combined with antibiotics for respiratory infections, but should not be taken with cough suppressants as they work in opposite ways.
Is carbocisteine safe for children?
Carbocisteine is generally not recommended for children under 12 years without medical supervision. Pediatric formulations may be available in some countries.
Can carbocisteine cure my chronic cough?
Carbocisteine manages symptoms by thinning mucus but does not cure the underlying condition. It should be used as part of a comprehensive treatment plan prescribed by your healthcare provider.
Does carbocisteine interact with food?
No significant food interactions have been reported. It can be taken with or without food.
Why Choose Our Carbocisteine?
- Pharmaceutical grade – High purity for therapeutic efficacy
- Consistent quality – Rigorous quality control testing
- Competitive pricing – Bulk orders welcomed
- Technical support – Expert guidance on applications
- Reliable supply – Consistent availability for your needs
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